DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment FASN1 and pks1

DIOPT Version :9

Sequence 1:NP_001137778.2 Gene:FASN1 / 33524 FlyBaseID:FBgn0283427 Length:2540 Species:Drosophila melanogaster
Sequence 2:XP_017209447.2 Gene:pks1 / 555390 ZFINID:ZDB-GENE-030131-2238 Length:2101 Species:Danio rerio


Alignment Length:2350 Identity:556/2350 - (23%)
Similarity:911/2350 - (38%) Gaps:591/2350 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   137 HLND-EIAITGFSGRLPESSTIEEFKQNLFDGVDMVNDDP-RRWERGLYGLPD--RIGKLKDS-- 195
            ||:| .|:.||        ..::.|.:.|.:|.:.|...| .|:|...:..||  ..||.:.:  
Zfish    13 HLHDLHISFTG--------EGVDNFWKVLVEGRNCVVQIPDERFETSEWFHPDEGEPGKTRTTTA 69

  Fly   196 ----DLENFDQQFFGVHQKQAECMDPLLRMLLELTHEAIIDAGLNPSDLRGSRTGVYIGVSNSET 256
                ....|||:|||:.:.:|:.|||..::||:..:.|:.|||:....:.|:|||||||:.|.:.
Zfish    70 ALIEGFNEFDQKFFGISEAEADYMDPQQKLLLQCAYRALEDAGIPLEKVSGTRTGVYIGLMNRDY 134

  Fly   257 EQHWCSDADRVNGYGLTGCARAMFANRISFTFDFKGPSYSIDTACSSSLYALEQAFSDMREGKVD 321
            |....:....:..|..||.|.::.|||||:.|:..|||::||:||||||.||..|...:|:|..:
Zfish   135 ETLLNNSPSTITHYNGTGTAMSIAANRISYIFNLTGPSFAIDSACSSSLVALHSACQAIRQGDCE 199

  Fly   322 NALVAGAGLILKPTMSLQFKRLNMLSPDGSCKAFDESGNGYVRSDGCVVLLLQRTSAA----RRV 382
            .||..|...||:|.:.:...:..|:||:|:.|.|..:.:||.|.:||.::||:....|    ..:
Zfish   200 MALCGGVSCILEPRVFVALSKAKMISPEGTSKPFCRTADGYGRGEGCGIVLLKSLKKAIEDFDHI 264

  Fly   383 YASILNVRTNTDGFKEQGITYPIGKMQNRLIRETYEEIGLNPADVVYVEAHGTGTKVGDPQEVNS 447
            :..:.....|.||.....||.|....|..|:|..|..... .|:|.|||||||||..|||.|..|
Zfish   265 WGIVNKTAVNQDGHTVTPITKPSMTQQEALLRMIYSSEDF-LANVQYVEAHGTGTPAGDPVEAGS 328

  Fly   448 ITDFFCKDRTT---PLLIGSVKSNMGHSEPASGVCSVAKILIAMEEGVIPGNLHYNKPNPDLYGL 509
            ::....|.|..   ||.:||||||:||:|.|:||..:.|||:.|:...|..:|.|:..|..    
Zfish   329 LSRVIAKTRPPSLGPLFVGSVKSNIGHTESAAGVAGLIKILLMMKHETIVPSLFYSAENSS---- 389

  Fly   510 VDGR---LKVVDRNLPW--NGGII---GLNSFGFGGANAHVILKSNPKP-----KALTPKDGALK 561
            :|.:   ||:..|...|  :|..|   |||||||||.|||.|:....:.     :.|.|    ||
Zfish   390 IDAKALNLKIPTRAEKWLYSGSRIKMAGLNSFGFGGTNAHAIITEYVQAAVFDRQTLEP----LK 450

  Fly   562 VVLASGRTFEAVEQLLESASTNADDDEYLQLINEIHSKAIP----NHFFRGYGVVSS-------- 614
            ::..|..|.::::..:.........||.:.|....::.|..    .|.||.....||        
Zfish   451 LLPLSAATDQSLQLCIADTYQRISADETVDLQALAYTSACRRSHIRHKFRKVFAASSLSELISLL 515

  Fly   615 KGTHQREVIESNDDKRPIWYIYSGMGSQWASMAKDLMKIE-AFAKTIQ---------RCA----- 664
            |.:..:::..:..|::.: :::.|.|..:..|.|.|:|.| .|...::         :|:     
Zfish   516 KASMNKKLAPTKQDQKLV-FVFCGNGVTYRGMCKQLLKEEPVFRSKVKEVESYFQKFKCSISQKI 579

  Fly   665 -------DVLKPEGVDLIDVLTRSTDKSFENILNSFISIAAMQVALTDLLSSLGIHPDGIVGHSV 722
                   |..||   |::..|                 :.|:||.:..||...||.||.::||||
Zfish   580 SSSYKDEDFSKP---DVVQPL-----------------LFAIQVGIGHLLRHWGIRPDIVLGHSV 624

  Fly   723 GELGCAYADGCFTPEQTVLAAYWRGKSILDTQLAKGKMAAVG-LSWEDAHSRVPSDCFPVC---H 783
            ||:..|:..|..:.|..|...|.|  |.|.|::..|:|..|| :...|....:|:....:|   .
Zfish   625 GEIAAAHCSGLLSLEDAVKVVYHR--SSLQTKVTGGRMLVVGNIPVLDVVEILPAYTGKICLAAL 687

  Fly   784 NSEDNCTISGPEASIEALVAKL----NAEGVFAKAVNSSGYAFHSKYIAEAGPKLRKSLEKIIPN 844
            ||..:|.:||.:.::|.:..||    .::.||...::... |:||           ..::.|:.:
Zfish   688 NSPMSCVLSGNKQTVENVHQKLQSLFESKNVFLHVLDVPA-AYHS-----------HMMDPILGH 740

  Fly   845 AKNRTARWISTSIPESAWNTPVAKQS------SAAYHVNNLLSPVLFHEALQHV---PKNAISVE 900
            .|:...:.....:....::|...::.      :..|...|:..||.|.:|::.|   .:|.:.||
Zfish   741 IKDSIGQLTGNEMECELFSTVTGQKCRQGDFVNGEYWARNIRKPVEFEQAIRSVSNHARNTVFVE 805

  Fly   901 IAPHGLLQAILKRALGPDATNLSLVKRGHENNVEFFLTNVGKLFAAGAQPQVLTLVRPISYPVGR 965
            |.|...||..:|..||.|.|.|..|:.|.:....|  ..|.|||..|.                 
Zfish   806 IGPRQALQRNIKEILGNDKTVLPSVQPGKDQQTMF--NTVSKLFELGV----------------- 851

  Fly   966 GTPMLNSKVGWDHTQKWLVA----------KFGK------------------------ETSSGET 996
                   .|.||...|...:          :|.|                        ::...:.
Zfish   852 -------NVKWDEFYKGFESELTAFPRYQFQFQKNDVHFEDVRRGHDSVSCSPYPLIIQSKHYDN 909

  Fly   997 IVEVDLSKEDDAFLAGHTIDGRILFPATGYMTLAWQTFAKMQGSEFHKTPV--VMENLVFHRATI 1059
            :::.:||...:::|..|...|..:.|...::.||:::..:....   |.|:  ...::.|....:
Zfish   910 VIKCNLSASTNSYLWEHKNKGISIAPGALFVELAFESVIETVAP---KRPLNSFQLSINFQSLLV 971

  Fly  1060 LNKNAV-VKFGINFFDGTGAFEICESGSLAVSGKITIPESIDNEELP--LEEQT--PSAVAKE-- 1117
            ||||.: :|..:.....|.:|:|..|.::..||      ::.:|..|  ||:||  .|:|.|.  
Zfish   972 LNKNYLPLKIKVETSKDTTSFQIVSSSTVHASG------TVCHEGGPAILEQQTIHLSSVLKRCQ 1030

  Fly  1118 --LGTNDVYKELRLRGYDYGGIFR-------------GIVRSDTVASTGKLQWVDNWI---SFMD 1164
              :.:.|||..|...|::||..|:             .:.|  .|...|.|..:..:.   ..:|
Zfish  1031 SVIESKDVYGTLNEVGFEYGPNFKQLEDIHYGQEFKEAVTR--VVIPEGVLNHLYEYCLHPVVLD 1093

  Fly  1165 TMLQFS----ILSKNLRELYLPTRIERAVINPAKHFELLSALTKEEQVETGLPVQWY---SDINV 1222
            ..||.|    ::|..:|..: |:.|...||:...|.|:...:...:|:.....|...   .|.:|
Zfish  1094 YFLQMSSVLGLVSSTIRPGF-PSAIGSMVISAPPHKEMFMYMRLTKQMSDYFEVCGCFTDKDGHV 1157

  Fly  1223 IKSAGVELRGLKANLAQRRPGTQAPPTLERYQFVPNINTTDLNENSEKARLHALDVAIQVIIENS 1287
            :    :|||.::...      ..|...:....|..|.......|:|...|:.||      :.|::
Zfish  1158 L----IELRDVRITF------LGAHGHIRDLCFFNNQKIDIHTESSFSRRIKAL------VFEDT 1206

  Fly  1288 SGAVKLKGVELANGRNP-----DVLVANRLLQIIEGEPVLTGDVAVVTSNNNEETITAALGDSGV 1347
            .|        :|.|..|     .|.|.         ||.||.:.|.:..   |...|.:..|..:
Zfish  1207 FG--------IAKGLKPYLHPKSVFVP---------EPELTKNSAFLVP---EFKSTCSAADMEL 1251

  Fly  1348 RVVSKDVLKEPVEQNCHFVFGIDVLSRPDTKTLENSIASIRENGFLILEETLPTYTKTGRALLTK 1412
            ..:.             |::||..:|...::.:.:|:....|    :..:.:.:....|||.   
Zfish  1252 DKIL-------------FIWGIQSISHLKSEAILDSLVDSCE----LYHQVVLSLRNCGRAC--- 1296

  Fly  1413 FGFVAVQEQSLGATRVLVLARKAVDLKTRKSVVVVATEQNFNWVDDLKAALATAATEEQYVYVVC 1477
                                          |:.|:........||.:..|...:....     .|
Zfish  1297 ------------------------------SIHVITYRSAEGIVDTISPAFVLSGMTR-----AC 1326

  Fly  1478 QGE---ELFGAVGLMTCIKNE--------NGGKLARL--VFVQDAKAEKFSLTSTLYRQQLEKDL 1529
            ..|   ..|..:.|.|..:.:        |..|..:.  |::...||....:|||         .
Zfish  1327 AAELSGISFQLIDLSTVSREDIETLGHVLNSYKTLQCPEVYISKGKAYSAVITST---------P 1382

  Fly  1530 ISNVLKNGAWGTFRHLKLETQQATLQVEHAYVNALVKGDLASLKWIEAAQADTAATVD-KNLETC 1593
            |:.:....:    :...|:....|||..:.|       .:.|:  :......|..|:| |::|  
Zfish  1383 ITTIETMNS----KSKCLQYHNFTLQTTNPY-------RMTSI--LALPSESTVNTIDRKSIE-- 1432

  Fly  1594 TVYYAPINFRDVMLTSGKLAADALPGDLAEQDC---------------VLGLEFA------GRDT 1637
                  |....|.:.|    :|..|...:|.:.               :|.|:|:      |:|.
Zfish  1433 ------IQLSKVCVHS----SDYFPVSTSELNFGQTVYWNKHSTQNHHLLVLDFSGIVTAVGKDV 1487

  Fly  1638 Q----GRRVMAMVPAKSLA------TTCVASKRMMWQIPEKWTMEEASTVPCVYSTVYYALVVR- 1691
            .    |..|:...|.|:.:      ..|...||..:          ...|||    ..|.:::| 
Zfish  1488 NRLKVGDHVICCYPVKATSKVVLPEDVCFKIKRFPF----------LKDVPC----ASYLVLIRE 1538

  Fly  1692 -------GQMKKGEKILIHAGSGGVGQAAI-----SVALAHGLTVFTT-----VGSKEKREFLLK 1739
                   ...|:.:.:.|.:   .|..:|:     .:|...|.:|||.     :....|:..||.
Zfish  1539 ILICMLPNTTKQQQSLSIFS---AVRDSALVKLLTIIASKSGWSVFTETEISGLVQSAKQCHLLV 1600

  Fly  1740 RFPKL------QERNIGNS---------RDTSFEQL-VLRETKGRGVDLVLNSLSEEKLQASIRC 1788
            ..|..      :..::.|:         ||.|:..| |.::...|   ....:|...|:....| 
Zfish  1601 IIPPFDCSLLTEIVSVANAYHTIALCGIRDPSYSALDVFQQDSER---TCFQTLEMSKIFQKSR- 1661

  Fly  1789 LGLNGRFLEIGKFDLSNNSPLGMSVFLKNTSFHGILLDSVMEGEEEMQNQVVSLVAEGIKTGAVV 1853
            |..:|.||:               .:||....|.:.        ..:|::...:..........|
Zfish  1662 LKAHGAFLQ---------------KWLKGMHLHKVW--------PTIQSRTFQMAPSESMPAQYV 1703

  Fly  1854 PLPTSVFNDQQVEQAFRFMASGKHIGKVVIKVRDEEAGKKALQPKPRLINAIP-----RTYMHPE 1913
            ....|.||.:.|:              |:....|:...|         |:|||     |.....|
Zfish  1704 EHSGSYFNARTVD--------------VITLAADDPRTK---------ISAIPLRPRARQLFSKE 1745

  Fly  1914 KSYILVGGLGGFGLELTNWLVTRGARYIVLTSRSG----VKTGYQGLMIRRWQERGVKVVIDTSD 1974
            ..||:.|||.|.|.|...::..:|...|...|||.    |:....||. ||:   ||:::....|
Zfish  1746 GVYIISGGLSGLGFETVKFVAQKGGGCIATLSRSAPSEKVQDDINGLK-RRY---GVRILTLQCD 1806

  Fly  1975 VTTAAGAKKLLENSNKLA------LVGGIFNLAAVLRDALIEDQTAKDFKTVADPKVTATKYLDQ 2033
            |   :..|:::|....:|      .:.|:|:.||||.|.|:|......|:.|..|||.....|..
Zfish  1807 V---SAQKQVMEAITMIANHFSCHPIRGVFHSAAVLHDGLLETLDRSLFRKVLQPKVCGALNLHL 1868

  Fly  2034 FSRDICTELDYFICFSSVSCGRGNIGQTNYGLANSAMERICEQRQVSGFPGTAIQWGAIGDTGLV 2098
            .:....| ||||:|:||:|...||..|.||..|||.::..|..|:..|.||.:|.||.: ..||:
Zfish  1869 ATLHSKT-LDYFVCYSSISSFIGNAAQANYAAANSFLDTFCHYRRNIGLPGQSINWGPL-KLGLL 1931

  Fly  2099 LENLGDNDTVIGGT----------LPQRMPSCLQTIDLFLQQPHPVVA----------------- 2136
            :..  ||......|          :.:.:..|     |.|..|..||.                 
Zfish  1932 MNK--DNFQKFLETKGLMIMDVAEIHEALEHC-----LLLDNPQQVVCRFNFRNLNNHVLSQNMS 1989

  Fly  2137 -----SMVVAE--KRKSDQSAGVSLIATIANILGL-------RDTKNIQDGASLADLGMDSLMSA 2187
                 |.:|.|  |.|..:.:|:|:.:::.:.:.:       .|:..:.|..:|..||:||::: 
Zfish  1990 LKFRLSALVEEGLKNKDAEDSGISVQSSVDDCVRVILTEICSVDSDELSDETTLTALGIDSMLA- 2053

  Fly  2188 EIKQTLERNF 2197
               .||:..|
Zfish  2054 ---MTLQNRF 2060

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FASN1NP_001137778.2 PksD 137..1142 CDD:225858 310/1143 (27%)
PKS 140..544 CDD:238429 156/428 (36%)
KAsynt_C_assoc 502..612 CDD:292814 34/126 (27%)
Acyl_transf_1 633..950 CDD:298668 89/355 (25%)
hot_dog 990..1234 CDD:294345 62/277 (22%)
NADB_Rossmann 1358..>1550 CDD:304358 29/204 (14%)
PKS_ER 1593..1883 CDD:214840 60/354 (17%)
enoyl_red 1595..1883 CDD:176179 60/352 (17%)
KR_1_FAS_SDR_x <1901..2141 CDD:187657 83/286 (29%)
PKS_PP 2154..>2206 CDD:214834 9/50 (18%)
Abhydrolase 2286..2535 CDD:304388
pks1XP_017209447.2 PksD 21..1063 CDD:225858 306/1128 (27%)
MDR 1453..>1518 CDD:327354 10/64 (16%)
KR_FAS_SDR_x <1730..1975 CDD:187582 81/260 (31%)
PP-binding 2022..2087 CDD:306928 9/42 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D19161at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
11.010

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