DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FASN1 and SPBC16A3.02c

DIOPT Version :9

Sequence 1:	NP_001137778.2	Gene:	FASN1 / 33524	FlyBaseID:	FBgn0283427	Length:	2540	Species:	Drosophila melanogaster
Sequence 2:	NP_596787.1	Gene:	SPBC16A3.02c / 2540039	PomBaseID:	SPBC16A3.02c	Length:	347	Species:	Schizosaccharomyces pombe

Alignment Length:	339	Identity:	82/339 - (24%)
Similarity:	141/339 - (41%)	Gaps:	79/339 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly  1587 DKNLETCTVYYAPINFRDVMLTSGKLAADA---LPGDLAEQDCVLGLEFAGR------------D 1636
            |..:|.......|::::  ::.:.::.|.|   ||.       :.|.:||||            .
pombe    45 DVLVEVVATSINPLDYK--LMNTYQMIAKALFKLPN-------IPGYDFAGRVLAVGSEVKEFSA 100

  Fly  1637 TQ-----------GRRVMAMVPAKSLATTCVASKRMMWQIPEKWTMEEASTVPCVYSTVYYALVV 1690
            ||           ||:      ..|.||..|...:.:|.:|:..:..|.:.......|.:..||.
pombe   101 TQRVWGCQSFPRAGRQ------GGSCATHIVTGDKDVWHLPDGVSFNEGAGFGIAGLTAWEVLVR 159

  Fly  1691 RGQMKKGEKILIHAGSGGVGQAAISVALAHGLTVFTTVGSKEKREFLLKRFPKLQERNIG--NSR 1753
            :.::|.|.|::|...|||||..|:::|.|....| ||:.|.|..:..         :::|  ::.
pombe   160 QMKVKPGTKLVIEGASGGVGTFAVALAKALECEV-TTISSTENLDLC---------KSLGATHTL 214

  Fly  1754 DTSFEQLVLRETKGRGVDLVLNSLSEEKL-QASIRCLGLNGRFLEI-GKFDLS----------NN 1806
            |...:.||.|.......|.|.:.:::..| :||.:.:..:|.|..| |...||          ..
pombe   215 DYKKDNLVERLADLGPYDFVFDCVNDNVLYRASSKFVKPDGAFFGIGGDITLSYVGSRLSRTLRP 279

  Fly  1807 SPLGMSVFLKNTSFHGILLDSVMEGEEEMQNQVVSLVAE-GIKTGAVVPLPTSVFNDQQVEQAFR 1870
            ..||.|    :.|::.|||    ..::||....|..|.: .|||     :..||::.:...:||.
pombe   280 RVLGGS----SHSYYNILL----HVDQEMLRDFVDFVMKHNIKT-----VIDSVYDFEDTVEAFN 331

  Fly  1871 FMASGKHIGKVVIK 1884
            .:.:.:..|||:||
pombe   332 RLMTHRCKGKVIIK 345

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FASN1	NP_001137778.2	PksD	137..1142	CDD:225858
		PKS	140..544	CDD:238429
		KAsynt_C_assoc	502..612	CDD:292814
		Acyl_transf_1	633..950	CDD:298668
		hot_dog	990..1234	CDD:294345
		NADB_Rossmann	1358..>1550	CDD:304358
		PKS_ER	1593..1883	CDD:214840	78/330 (24%)
		enoyl_red	1595..1883	CDD:176179	78/328 (24%)
		KR_1_FAS_SDR_x	<1901..2141	CDD:187657
		PKS_PP	2154..>2206	CDD:214834
		Abhydrolase	2286..2535	CDD:304388
SPBC16A3.02c	NP_596787.1	Qor	14..345	CDD:223677	80/337 (24%)
SPBC16A3.02c	NP_596787.1	MDR1	15..344	CDD:176228	80/336 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9266
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910