DRSC/TRiP Functional Genomics Resources

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Protein Alignment FASN1 and FASN

DIOPT Version :9

Sequence 1:NP_001137778.2 Gene:FASN1 / 33524 FlyBaseID:FBgn0283427 Length:2540 Species:Drosophila melanogaster
Sequence 2:NP_004095.4 Gene:FASN / 2194 HGNCID:3594 Length:2511 Species:Homo sapiens


Alignment Length:2579 Identity:1109/2579 - (43%)
Similarity:1555/2579 - (60%) Gaps:266/2579 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly   140 DEIAITGFSGRLPESSTIEEFKQNLFDGVDMVNDDPRRWERGLYGLPDRIGKLKDSDLENFDQQF 204
            :|:.|.|.||:||||..::||..||..|||||.||.|||:.||||||.|.||||  ||..||..|
Human     2 EEVVIAGMSGKLPESENLQEFWDNLIGGVDMVTDDDRRWKAGLYGLPRRSGKLK--DLSRFDASF 64

  Fly   205 FGVHQKQAECMDPLLRMLLELTHEAIIDAGLNPSDLRGSRTGVYIGVSNSETEQHWCSDADRVNG 269
            ||||.|||..|||.||:|||:|:|||:|.|:||..|||:.|||::|||.|||.:....|.:.:.|
Human    65 FGVHPKQAHTMDPQLRLLLEVTYEAIVDGGINPDSLRGTHTGVWVGVSGSETSEALSRDPETLVG 129

  Fly   270 YGLTGCARAMFANRISFTFDFKGPSYSIDTACSSSLYALEQAFSDMREGKVDNALVAGAGLILKP 334
            |.:.||.|||.|||:||.|||:|||.::||||||||.||:.|:..:..|:...|:|.|..::|||
Human   130 YSMVGCQRAMMANRLSFFFDFRGPSIALDTACSSSLMALQNAYQAIHSGQCPAAIVGGINVLLKP 194

  Fly   335 TMSLQFKRLNMLSPDGSCKAFDESGNGYVRSDGCVVLLLQRTSAARRVYASILNVRTNTDGFKEQ 399
            ..|:||.||.||||:|:|||||.:||||.||:|.|.:||.:.|.||||||:|||..|||||||||
Human   195 NTSVQFLRLGMLSPEGTCKAFDTAGNGYCRSEGVVAVLLTKKSLARRVYATILNAGTNTDGFKEQ 259

  Fly   400 GITYPIGKMQNRLIRETYEEIGLNPADVVYVEAHGTGTKVGDPQEVNSITDFFCKDRTTPLLIGS 464
            |:|:|.|.:|.:|||..|:..|:.|....|:||||||||||||||:|.||...|..|..||||||
Human   260 GVTFPSGDIQEQLIRSLYQSAGVAPESFEYIEAHGTGTKVGDPQELNGITRALCATRQEPLLIGS 324

  Fly   465 VKSNMGHSEPASGVCSVAKILIAMEEGVIPGNLHYNKPNPDLYGLVDGRLKVVDRNLPWNGGIIG 529
            .||||||.|||||:.::||:|:::|.|:...|||::.|||::..|:||||:|||:.||..||.:|
Human   325 TKSNMGHPEPASGLAALAKVLLSLEHGLWAPNLHFHSPNPEIPALLDGRLQVVDQPLPVRGGNVG 389

  Fly   530 LNSFGFGGANAHVILKSN------PKPKALTPKDGALKVVLASGRTFEAVEQLLESASTNADDDE 588
            :|||||||:|.|:||:.|      |.|.|..|     :::.|||||.|||::|||....::.|..
Human   390 INSFGFGGSNVHIILRPNTQPPPAPAPHATLP-----RLLRASGRTPEAVQKLLEQGLRHSQDLA 449

  Fly   589 YLQLINEI---HSKAIPNHFFRGYGVV-SSKGTHQREVIESNDDKRPIWYIYSGMGSQWASMAKD 649
            :|.::|:|   .:.|:|   ||||.|: ..:|..:.:.:.:.:  ||:|:|.||||:||..|...
Human   450 FLSMLNDIAAVPATAMP---FRGYAVLGGERGGPEVQQVPAGE--RPLWFICSGMGTQWRGMGLS 509

  Fly   650 LMKIEAFAKTIQRCADVLKPEGVDLIDVLTRSTDKSFENILNSFISIAAMQVALTDLLSSLGIHP 714
            ||:::.|..:|.|..:.:||.|:.:..:|..:.:.:|::|::||:|:.|:|:.|.||||.:|:.|
Human   510 LMRLDRFRDSILRSDEAVKPFGLKVSQLLLSTDESTFDDIVHSFVSLTAIQIGLIDLLSCMGLRP 574

  Fly   715 DGIVGHSVGELGCAYADGCFTPEQTVLAAYWRGKSILDTQLAKGKMAAVGLSWEDAHSRVPSDCF 779
            |||||||:||:.|.|||||.:.|:.||||||||:.|.:..|..|.|||||||||:...|.|....
Human   575 DGIVGHSLGEVACGYADGCLSQEEAVLAAYWRGQCIKEAHLPPGAMAAVGLSWEECKQRCPPGVV 639

  Fly   780 PVCHNSEDNCTISGPEASIEALVAKLNAEGVFAKAVNSSGYAFHSKYIAEAGPKLRKSLEKIIPN 844
            |.||||:|..|||||:|.:...|.:|..||||||.|.:.|.||||.::....|.|.:.|:|:|..
Human   640 PACHNSKDTVTISGPQAPVFEFVEQLRKEGVFAKEVRTGGMAFHSYFMEAIAPPLLQELKKVIRE 704

  Fly   845 AKNRTARWISTSIPESAWNTPVAKQSSAAYHVNNLLSPVLFHEALQHVPKNAISVEIAPHGLLQA 909
            .|.|:|||:||||||:.|::.:|:.|||.|:||||:|||||.|||.|||::|:.:|||||.||||
Human   705 PKPRSARWLSTSIPEAQWHSSLARTSSAEYNVNNLVSPVLFQEALWHVPEHAVVLEIAPHALLQA 769

  Fly   910 ILKRALGPDATNLSLVKRGHENNVEFFLTNVGKLFAAGAQPQVLTLVRPISYPVGRGTPMLNSKV 974
            :|||.|.|..|.:.|:|:.|.:|:||||..:|:|..:|.......|..|:.:|..||||:::..:
Human   770 VLKRGLKPSCTIIPLMKKDHRDNLEFFLAGIGRLHLSGIDANPNALFPPVEFPAPRGTPLISPLI 834

  Fly   975 GWDHTQKWLV-AKFGKETSSGE---TIVEVDLSKED-DAFLAGHTIDGRILFPATGYMTLAWQTF 1034
            .|||:..|.| |.......||.   .|..:|.|.|. |.:|..||:|||:|||||||:::.|:|.
Human   835 KWDHSLAWDVPAAEDFPNGSGSPSAAIYNIDTSSESPDHYLVDHTLDGRVLFPATGYLSIVWKTL 899

  Fly  1035 AKMQGSEFHKTPVVMENLVFHRATILNKNAVVKFGINFFDGTGAFEICESGSLAVSGKI-----T 1094
            |:..|....:.|||.|::|.|:||||.|...|...:...:.:.|||:.|:|:|.||||:     .
Human   900 ARALGLGVEQLPVVFEDVVLHQATILPKTGTVSLEVRLLEASRAFEVSENGNLVVSGKVYQWDDP 964

  Fly  1095 IPESIDNEELPLEEQT-PSAVAKELGTNDVYKELRLRGYDYGGIFRGIVRSDTVASTGKLQWVDN 1158
            .|...|:.|.|....| |..:|:.    :|||||||||||||..|:||:.:.....:|:|.|.||
Human   965 DPRLFDHPESPTPNPTEPLFLAQA----EVYKELRLRGYDYGPHFQGILEASLEGDSGRLLWKDN 1025

  Fly  1159 WISFMDTMLQFSILSKNLRELYLPTRIERAVINPAKHFELLSALTKEEQVETGLPVQWYSDINVI 1223
            |:||||||||.|||......||||||:....|:||.|.:.|..|..:.||...:..:|   :.|.
Human  1026 WVSFMDTMLQMSILGSAKHGLYLPTRVTAIHIDPATHRQKLYTLQDKAQVADVVVSRW---LRVT 1087

  Fly  1224 KSAGVELRGLKANLAQRRPGTQAPPTLERYQFVPNINTTDLNENS-------------------- 1268
            .:.||.:.||....|.||...|..|.||::.|.|:.....|:|.:                    
Human  1088 VAGGVHISGLHTESAPRRQQEQQVPILEKFCFTPHTEEGCLSERAALQEELQLCKGLVQALQTKV 1152

  Fly  1269 ----------------------------------------------------EKARL-------- 1273
                                                                |:.:|        
Human  1153 TQQGLKMVVPGLDGAQIPRDPSQQELPRLLSAACRLQLNGNLQLELAQVLAQERPKLPEDPLLSG 1217

  Fly  1274 ----HALDVAIQVIIENSSGAVKLKGVELANG------RNPDVLVANRLLQIIEGEPVLTGDVAV 1328
                .||...:...:||.. ::|:|.||:..|      |.|.:|..:.|||:           :.
Human  1218 LLDSPALKACLDTAVENMP-SLKMKVVEVLAGHGHLYSRIPGLLSPHPLLQL-----------SY 1270

  Fly  1329 VTSNNNEETITAALGDSGVRVVSKDVLK---EPVEQ-------------NCHFVFGIDVLSRPDT 1377
            ..::.:.:.:.||..:    :...||.:   :|.:.             ||    .:..|..| .
Human  1271 TATDRHPQALEAAQAE----LQQHDVAQGQWDPADPAPSALGSADLLVCNC----AVAALGDP-A 1326

  Fly  1378 KTLENSIASIRENGFLILE----------------ETLPTYTKTGRALLTK-----------FGF 1415
            ..|.|.:|::||.|||:|.                .|.|.|   |:.:|::           ...
Human  1327 SALSNMVAALREGGFLLLHTLLRGHPLGDIVAFLTSTEPQY---GQGILSQDAWESLFSRVSLRL 1388

  Fly  1416 VAVQEQSLGATRVLVLARKAVDLKTRKSVVVVATEQNFNWVDDLKAALATAATEEQYVYVVCQGE 1480
            |.:::...|:|  |.|.|:.....:  .:.:...:.:|.||:.||..||...:... |::.....
Human  1389 VGLKKSFYGST--LFLCRRPTPQDS--PIFLPVDDTSFRWVESLKGILADEDSSRP-VWLKAINC 1448

  Fly  1481 ELFGAVGLMTCIKNENGGKLARLVFVQDAKAEKFSLTSTLY-----------RQQLEKDLISNVL 1534
            ...|.|||:.|::.|.||...|.|.:.       :|:||.:           ::.|:.||:.||.
Human  1449 ATSGVVGLVNCLRREPGGNRLRCVLLS-------NLSSTSHVPEVDPGSAELQKVLQGDLVMNVY 1506

  Fly  1535 KNGAWGTFRHLKLETQQATLQVEHAYVNALVKGDLASLKWIEAAQADTAATVDKNLETCTVYYAP 1599
            ::||||.|||..||..:......||:|:.|.:|||:|::|:.::......|. ...:.||||||.
Human  1507 RDGAWGAFRHFLLEEDKPEEPTAHAFVSTLTRGDLSSIRWVCSSLRHAQPTC-PGAQLCTVYYAS 1570

  Fly  1600 INFRDVMLTSGKLAADALPGDLAEQDCVLGLEFAGRDTQGRRVMAMVPAKSLATTCVASKRMMWQ 1664
            :||||:||.:|||:.||:||....||.:||:||:|||..|:|||.:||||.|||:.:.|...:|.
Human  1571 LNFRDIMLATGKLSPDAIPGKWTSQDSLLGMEFSGRDASGKRVMGLVPAKGLATSVLLSPDFLWD 1635

  Fly  1665 IPEKWTMEEASTVPCVYSTVYYALVVRGQMKKGEKILIHAGSGGVGQAAISVALAHGLTVFTTVG 1729
            :|..||:|||::||.||||.||||||||:::.||.:|||:||||||||||::||:.|..||||||
Human  1636 VPSNWTLEEAASVPVVYSTAYYALVVRGRVRPGETLLIHSGSGGVGQAAIAIALSLGCRVFTTVG 1700

  Fly  1730 SKEKREFLLKRFPKLQERNIGNSRDTSFEQLVLRETKGRGVDLVLNSLSEEKLQASIRCLGLNGR 1794
            |.|||.:|..|||:|...:..|||||||||.||..|.|:|||||||||:|||||||:|||..:||
Human  1701 SAEKRAYLQARFPQLDSTSFANSRDTSFEQHVLWHTGGKGVDLVLNSLAEEKLQASVRCLATHGR 1765

  Fly  1795 FLEIGKFDLSNNSPLGMSVFLKNTSFHGILLDSVMEGEEEMQNQVVSLVAEGIKTGAVVPLPTSV 1859
            ||||||||||.|.||||::||||.:|||:|||:..........:|.:||..||:.|.|.||..:|
Human  1766 FLEIGKFDLSQNHPLGMAIFLKNVTFHGVLLDAFFNESSADWREVWALVQAGIRDGVVRPLKCTV 1830

  Fly  1860 FNDQQVEQAFRFMASGKHIGKVVIKVRDEEAGKKALQPKPRLINAIPRTYMHPEKSYILVGGLGG 1924
            |:..|||.|||:||.||||||||::|..||........||:|::||.:|:....||||:.|||||
Human  1831 FHGAQVEDAFRYMAQGKHIGKVVVQVLAEEPEAVLKGAKPKLMSAISKTFCPAHKSYIIAGGLGG 1895

  Fly  1925 FGLELTNWLVTRGARYIVLTSRSGVKTGYQGLMIRRWQERGVKVVIDTSDVTTAAGAKKLLENSN 1989
            |||||..||:.||.:.:|||||||::||||...:|||:.:||:|.:.||::::..||:.|:..:.
Human  1896 FGLELAQWLIQRGVQKLVLTSRSGIRTGYQAKQVRRWRRQGVQVQVSTSNISSLEGARGLIAEAA 1960

  Fly  1990 KLALVGGIFNLAAVLRDALIEDQTAKDFKTVADPKVTATKYLDQFSRDICTELDYFICFSSVSCG 2054
            :|..|||:||||.||||.|:|:||.:.|:.|..||.:.|..||:.:|:.|.|||||:.|||||||
Human  1961 QLGPVGGVFNLAVVLRDGLLENQTPEFFQDVCKPKYSGTLNLDRVTREACPELDYFVVFSSVSCG 2025

  Fly  2055 RGNIGQTNYGLANSAMERICEQRQVSGFPGTAIQWGAIGDTGLVLENLGDNDTVIGGTLPQRMPS 2119
            |||.||:|||.||||||||||:|:..|.||.|:|||||||.|:::|.:..|||::.|||||||.|
Human  2026 RGNAGQSNYGFANSAMERICEKRRHEGLPGLAVQWGAIGDVGILVETMSTNDTIVSGTLPQRMAS 2090

  Fly  2120 CLQTIDLFLQQPHPVVASMVVAEKRKS--DQSAGVSLIATIANILGLRDTKNIQDGASLADLGMD 2182
            ||:.:||||.|||.|::|.|:|||..:  |:.:...|:..:|:|||:||...:...:||||||:|
Human  2091 CLEVLDLFLNQPHMVLSSFVLAEKAAAYRDRDSQRDLVEAVAHILGIRDLAAVNLDSSLADLGLD 2155

  Fly  2183 SLMSAEIKQTLERNFDIVLSAQEIRQLTFGALKAMDGGADVKPAAAAPAAAAGVPEANITSGGSS 2247
            ||||.|::|||||..::|||.:|:||||...|:.:...||.....|.|                 
Human  2156 SLMSVEVRQTLERELNLVLSVREVRQLTLRKLQELSSKADEASELACP----------------- 2203

  Fly  2248 RTASPMGDG-----TQVVFTTSLIPTE--AIVQLDTKAPANSKQSPIFFISPIEGFASALEPLAK 2305
               :|..||     ||:...:.|:..|  .:::|::   ..|.:.|:|.:.||||..:....||.
Human  2204 ---TPKEDGLAQQQTQLNLRSLLVNPEGPTLMRLNS---VQSSERPLFLVHPIEGSTTVFHSLAS 2262

  Fly  2306 RLEVPAYGLQYTEAVPSDSLESAAKFFIKQLRTVQPKGPYKLAGYSFGCLLTYVMAGILEETNEV 2370
            ||.:|.||||.|.|.|.||:.|.|.::|..:|.|||:|||::||||:|..:.:.|...|:.....
Human  2263 RLSIPTYGLQCTRAAPLDSIHSLAAYYIDCIRQVQPEGPYRVAGYSYGACVAFEMCSQLQAQQSP 2327

  Fly  2371 A----NVIMLDGAPSYVNWYTSSFKQRYTDGTNADNDNQSYGLAYFGIVLANIDYKALVRLLIVI 2431
            |    ::.:.||:|:||..||.|::.:.|.|..|:.:.::  :.:|.....::::..::..|:.:
Human  2328 APTHNSLFLFDGSPTYVLAYTQSYRAKLTPGCEAEAETEA--ICFFVQQFTDMEHNRVLEALLPL 2390

  Fly  2432 PTWEEKLERFAELM--SNEITQPVETIKKSATLFYKKLELADGYQPTLKLKTNVTLVKPTDNSA- 2493
            ...||::....:|:  |::.....| :..:|..||.||..|:.|.|..|...||.|::.....| 
Human  2391 KGLEERVAAAVDLIIKSHQGLDRQE-LSFAARSFYYKLRAAEQYTPKAKYHGNVMLLRAKTGGAY 2454

  Fly  2494 --KLDEDYRLKEVCTKPVEVHTVEGNHRTFLIEDQSLKTIQSIL 2535
              .|..||.|.:||...|.||.:||:||| |:|...|::|.||:
Human  2455 GEDLGADYNLSQVCDGKVSVHVIEGDHRT-LLEGSGLESIISII 2497

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
FASN1NP_001137778.2 PksD 137..1142 CDD:225858 509/1022 (50%)
PKS 140..544 CDD:238429 236/403 (59%)
KAsynt_C_assoc 502..612 CDD:292814 53/118 (45%)
Acyl_transf_1 633..950 CDD:298668 160/316 (51%)
hot_dog 990..1234 CDD:294345 105/253 (42%)
NADB_Rossmann 1358..>1550 CDD:304358 60/242 (25%)
PKS_ER 1593..1883 CDD:214840 179/289 (62%)
enoyl_red 1595..1883 CDD:176179 177/287 (62%)
KR_1_FAS_SDR_x <1901..2141 CDD:187657 136/239 (57%)
PKS_PP 2154..>2206 CDD:214834 27/51 (53%)
Abhydrolase 2286..2535 CDD:304388 88/257 (34%)
FASNNP_004095.4 PksD 1..1022 CDD:225858 512/1035 (49%)
Beta-ketoacyl synthase. /evidence=ECO:0000250 1..414 239/413 (58%)
PKS 2..404 CDD:238429 236/403 (59%)
KAsynt_C_assoc 362..474 CDD:292814 54/119 (45%)
Acyl and malonyl transferases. /evidence=ECO:0000250 429..817 183/392 (47%)
Acyl_transf_1 493..810 CDD:279088 160/316 (51%)