|
Fly 140 DEIAITGFSGRLPESSTIEEFKQNLFDGVDMVNDDPRRWERGLYGLPDRIGKLKDSDLENFDQQF 204
:|:.|.|.||:||||..::||..||..|||||.||.|||:.||||||.|.|||| ||..||..|
Human 2 EEVVIAGMSGKLPESENLQEFWDNLIGGVDMVTDDDRRWKAGLYGLPRRSGKLK--DLSRFDASF 64
Fly 205 FGVHQKQAECMDPLLRMLLELTHEAIIDAGLNPSDLRGSRTGVYIGVSNSETEQHWCSDADRVNG 269
||||.|||..|||.||:|||:|:|||:|.|:||..|||:.|||::|||.|||.:....|.:.:.|
Human 65 FGVHPKQAHTMDPQLRLLLEVTYEAIVDGGINPDSLRGTHTGVWVGVSGSETSEALSRDPETLVG 129
Fly 270 YGLTGCARAMFANRISFTFDFKGPSYSIDTACSSSLYALEQAFSDMREGKVDNALVAGAGLILKP 334
|.:.||.|||.|||:||.|||:|||.::||||||||.||:.|:..:..|:...|:|.|..::|||
Human 130 YSMVGCQRAMMANRLSFFFDFRGPSIALDTACSSSLMALQNAYQAIHSGQCPAAIVGGINVLLKP 194
Fly 335 TMSLQFKRLNMLSPDGSCKAFDESGNGYVRSDGCVVLLLQRTSAARRVYASILNVRTNTDGFKEQ 399
..|:||.||.||||:|:|||||.:||||.||:|.|.:||.:.|.||||||:|||..|||||||||
Human 195 NTSVQFLRLGMLSPEGTCKAFDTAGNGYCRSEGVVAVLLTKKSLARRVYATILNAGTNTDGFKEQ 259
Fly 400 GITYPIGKMQNRLIRETYEEIGLNPADVVYVEAHGTGTKVGDPQEVNSITDFFCKDRTTPLLIGS 464
|:|:|.|.:|.:|||..|:..|:.|....|:||||||||||||||:|.||...|..|..||||||
Human 260 GVTFPSGDIQEQLIRSLYQSAGVAPESFEYIEAHGTGTKVGDPQELNGITRALCATRQEPLLIGS 324
Fly 465 VKSNMGHSEPASGVCSVAKILIAMEEGVIPGNLHYNKPNPDLYGLVDGRLKVVDRNLPWNGGIIG 529
.||||||.|||||:.::||:|:::|.|:...|||::.|||::..|:||||:|||:.||..||.:|
Human 325 TKSNMGHPEPASGLAALAKVLLSLEHGLWAPNLHFHSPNPEIPALLDGRLQVVDQPLPVRGGNVG 389
Fly 530 LNSFGFGGANAHVILKSN------PKPKALTPKDGALKVVLASGRTFEAVEQLLESASTNADDDE 588
:|||||||:|.|:||:.| |.|.|..| :::.|||||.|||::|||....::.|..
Human 390 INSFGFGGSNVHIILRPNTQPPPAPAPHATLP-----RLLRASGRTPEAVQKLLEQGLRHSQDLA 449
Fly 589 YLQLINEI---HSKAIPNHFFRGYGVV-SSKGTHQREVIESNDDKRPIWYIYSGMGSQWASMAKD 649
:|.::|:| .:.|:| ||||.|: ..:|..:.:.:.:.: ||:|:|.||||:||..|...
Human 450 FLSMLNDIAAVPATAMP---FRGYAVLGGERGGPEVQQVPAGE--RPLWFICSGMGTQWRGMGLS 509
Fly 650 LMKIEAFAKTIQRCADVLKPEGVDLIDVLTRSTDKSFENILNSFISIAAMQVALTDLLSSLGIHP 714
||:::.|..:|.|..:.:||.|:.:..:|..:.:.:|::|::||:|:.|:|:.|.||||.:|:.|
Human 510 LMRLDRFRDSILRSDEAVKPFGLKVSQLLLSTDESTFDDIVHSFVSLTAIQIGLIDLLSCMGLRP 574
Fly 715 DGIVGHSVGELGCAYADGCFTPEQTVLAAYWRGKSILDTQLAKGKMAAVGLSWEDAHSRVPSDCF 779
|||||||:||:.|.|||||.:.|:.||||||||:.|.:..|..|.|||||||||:...|.|....
Human 575 DGIVGHSLGEVACGYADGCLSQEEAVLAAYWRGQCIKEAHLPPGAMAAVGLSWEECKQRCPPGVV 639
Fly 780 PVCHNSEDNCTISGPEASIEALVAKLNAEGVFAKAVNSSGYAFHSKYIAEAGPKLRKSLEKIIPN 844
|.||||:|..|||||:|.:...|.:|..||||||.|.:.|.||||.::....|.|.:.|:|:|..
Human 640 PACHNSKDTVTISGPQAPVFEFVEQLRKEGVFAKEVRTGGMAFHSYFMEAIAPPLLQELKKVIRE 704
Fly 845 AKNRTARWISTSIPESAWNTPVAKQSSAAYHVNNLLSPVLFHEALQHVPKNAISVEIAPHGLLQA 909
.|.|:|||:||||||:.|::.:|:.|||.|:||||:|||||.|||.|||::|:.:|||||.||||
Human 705 PKPRSARWLSTSIPEAQWHSSLARTSSAEYNVNNLVSPVLFQEALWHVPEHAVVLEIAPHALLQA 769
Fly 910 ILKRALGPDATNLSLVKRGHENNVEFFLTNVGKLFAAGAQPQVLTLVRPISYPVGRGTPMLNSKV 974
:|||.|.|..|.:.|:|:.|.:|:||||..:|:|..:|.......|..|:.:|..||||:::..:
Human 770 VLKRGLKPSCTIIPLMKKDHRDNLEFFLAGIGRLHLSGIDANPNALFPPVEFPAPRGTPLISPLI 834
Fly 975 GWDHTQKWLV-AKFGKETSSGE---TIVEVDLSKED-DAFLAGHTIDGRILFPATGYMTLAWQTF 1034
.|||:..|.| |.......||. .|..:|.|.|. |.:|..||:|||:|||||||:::.|:|.
Human 835 KWDHSLAWDVPAAEDFPNGSGSPSAAIYNIDTSSESPDHYLVDHTLDGRVLFPATGYLSIVWKTL 899
Fly 1035 AKMQGSEFHKTPVVMENLVFHRATILNKNAVVKFGINFFDGTGAFEICESGSLAVSGKI-----T 1094
|:..|....:.|||.|::|.|:||||.|...|...:...:.:.|||:.|:|:|.||||: .
Human 900 ARALGLGVEQLPVVFEDVVLHQATILPKTGTVSLEVRLLEASRAFEVSENGNLVVSGKVYQWDDP 964
Fly 1095 IPESIDNEELPLEEQT-PSAVAKELGTNDVYKELRLRGYDYGGIFRGIVRSDTVASTGKLQWVDN 1158
.|...|:.|.|....| |..:|:. :|||||||||||||..|:||:.:.....:|:|.|.||
Human 965 DPRLFDHPESPTPNPTEPLFLAQA----EVYKELRLRGYDYGPHFQGILEASLEGDSGRLLWKDN 1025
Fly 1159 WISFMDTMLQFSILSKNLRELYLPTRIERAVINPAKHFELLSALTKEEQVETGLPVQWYSDINVI 1223
|:||||||||.|||......||||||:....|:||.|.:.|..|..:.||...:..:| :.|.
Human 1026 WVSFMDTMLQMSILGSAKHGLYLPTRVTAIHIDPATHRQKLYTLQDKAQVADVVVSRW---LRVT 1087
Fly 1224 KSAGVELRGLKANLAQRRPGTQAPPTLERYQFVPNINTTDLNENS-------------------- 1268
.:.||.:.||....|.||...|..|.||::.|.|:.....|:|.:
Human 1088 VAGGVHISGLHTESAPRRQQEQQVPILEKFCFTPHTEEGCLSERAALQEELQLCKGLVQALQTKV 1152
Fly 1269 ----------------------------------------------------EKARL-------- 1273
|:.:|
Human 1153 TQQGLKMVVPGLDGAQIPRDPSQQELPRLLSAACRLQLNGNLQLELAQVLAQERPKLPEDPLLSG 1217
Fly 1274 ----HALDVAIQVIIENSSGAVKLKGVELANG------RNPDVLVANRLLQIIEGEPVLTGDVAV 1328
.||...:...:||.. ::|:|.||:..| |.|.:|..:.|||: :.
Human 1218 LLDSPALKACLDTAVENMP-SLKMKVVEVLAGHGHLYSRIPGLLSPHPLLQL-----------SY 1270
Fly 1329 VTSNNNEETITAALGDSGVRVVSKDVLK---EPVEQ-------------NCHFVFGIDVLSRPDT 1377
..::.:.:.:.||..: :...||.: :|.:. || .:..|..| .
Human 1271 TATDRHPQALEAAQAE----LQQHDVAQGQWDPADPAPSALGSADLLVCNC----AVAALGDP-A 1326
Fly 1378 KTLENSIASIRENGFLILE----------------ETLPTYTKTGRALLTK-----------FGF 1415
..|.|.:|::||.|||:|. .|.|.| |:.:|:: ...
Human 1327 SALSNMVAALREGGFLLLHTLLRGHPLGDIVAFLTSTEPQY---GQGILSQDAWESLFSRVSLRL 1388
Fly 1416 VAVQEQSLGATRVLVLARKAVDLKTRKSVVVVATEQNFNWVDDLKAALATAATEEQYVYVVCQGE 1480
|.:::...|:| |.|.|:.....: .:.:...:.:|.||:.||..||...:... |::.....
Human 1389 VGLKKSFYGST--LFLCRRPTPQDS--PIFLPVDDTSFRWVESLKGILADEDSSRP-VWLKAINC 1448
Fly 1481 ELFGAVGLMTCIKNENGGKLARLVFVQDAKAEKFSLTSTLY-----------RQQLEKDLISNVL 1534
...|.|||:.|::.|.||...|.|.:. :|:||.: ::.|:.||:.||.
Human 1449 ATSGVVGLVNCLRREPGGNRLRCVLLS-------NLSSTSHVPEVDPGSAELQKVLQGDLVMNVY 1506
Fly 1535 KNGAWGTFRHLKLETQQATLQVEHAYVNALVKGDLASLKWIEAAQADTAATVDKNLETCTVYYAP 1599
::||||.|||..||..:......||:|:.|.:|||:|::|:.::......|. ...:.||||||.
Human 1507 RDGAWGAFRHFLLEEDKPEEPTAHAFVSTLTRGDLSSIRWVCSSLRHAQPTC-PGAQLCTVYYAS 1570
Fly 1600 INFRDVMLTSGKLAADALPGDLAEQDCVLGLEFAGRDTQGRRVMAMVPAKSLATTCVASKRMMWQ 1664
:||||:||.:|||:.||:||....||.:||:||:|||..|:|||.:||||.|||:.:.|...:|.
Human 1571 LNFRDIMLATGKLSPDAIPGKWTSQDSLLGMEFSGRDASGKRVMGLVPAKGLATSVLLSPDFLWD 1635
Fly 1665 IPEKWTMEEASTVPCVYSTVYYALVVRGQMKKGEKILIHAGSGGVGQAAISVALAHGLTVFTTVG 1729
:|..||:|||::||.||||.||||||||:::.||.:|||:||||||||||::||:.|..||||||
Human 1636 VPSNWTLEEAASVPVVYSTAYYALVVRGRVRPGETLLIHSGSGGVGQAAIAIALSLGCRVFTTVG 1700
Fly 1730 SKEKREFLLKRFPKLQERNIGNSRDTSFEQLVLRETKGRGVDLVLNSLSEEKLQASIRCLGLNGR 1794
|.|||.:|..|||:|...:..|||||||||.||..|.|:|||||||||:|||||||:|||..:||
Human 1701 SAEKRAYLQARFPQLDSTSFANSRDTSFEQHVLWHTGGKGVDLVLNSLAEEKLQASVRCLATHGR 1765
Fly 1795 FLEIGKFDLSNNSPLGMSVFLKNTSFHGILLDSVMEGEEEMQNQVVSLVAEGIKTGAVVPLPTSV 1859
||||||||||.|.||||::||||.:|||:|||:..........:|.:||..||:.|.|.||..:|
Human 1766 FLEIGKFDLSQNHPLGMAIFLKNVTFHGVLLDAFFNESSADWREVWALVQAGIRDGVVRPLKCTV 1830
Fly 1860 FNDQQVEQAFRFMASGKHIGKVVIKVRDEEAGKKALQPKPRLINAIPRTYMHPEKSYILVGGLGG 1924
|:..|||.|||:||.||||||||::|..||........||:|::||.:|:....||||:.|||||
Human 1831 FHGAQVEDAFRYMAQGKHIGKVVVQVLAEEPEAVLKGAKPKLMSAISKTFCPAHKSYIIAGGLGG 1895
Fly 1925 FGLELTNWLVTRGARYIVLTSRSGVKTGYQGLMIRRWQERGVKVVIDTSDVTTAAGAKKLLENSN 1989
|||||..||:.||.:.:|||||||::||||...:|||:.:||:|.:.||::::..||:.|:..:.
Human 1896 FGLELAQWLIQRGVQKLVLTSRSGIRTGYQAKQVRRWRRQGVQVQVSTSNISSLEGARGLIAEAA 1960
Fly 1990 KLALVGGIFNLAAVLRDALIEDQTAKDFKTVADPKVTATKYLDQFSRDICTELDYFICFSSVSCG 2054
:|..|||:||||.||||.|:|:||.:.|:.|..||.:.|..||:.:|:.|.|||||:.|||||||
Human 1961 QLGPVGGVFNLAVVLRDGLLENQTPEFFQDVCKPKYSGTLNLDRVTREACPELDYFVVFSSVSCG 2025
Fly 2055 RGNIGQTNYGLANSAMERICEQRQVSGFPGTAIQWGAIGDTGLVLENLGDNDTVIGGTLPQRMPS 2119
|||.||:|||.||||||||||:|:..|.||.|:|||||||.|:::|.:..|||::.|||||||.|
Human 2026 RGNAGQSNYGFANSAMERICEKRRHEGLPGLAVQWGAIGDVGILVETMSTNDTIVSGTLPQRMAS 2090
Fly 2120 CLQTIDLFLQQPHPVVASMVVAEKRKS--DQSAGVSLIATIANILGLRDTKNIQDGASLADLGMD 2182
||:.:||||.|||.|::|.|:|||..: |:.:...|:..:|:|||:||...:...:||||||:|
Human 2091 CLEVLDLFLNQPHMVLSSFVLAEKAAAYRDRDSQRDLVEAVAHILGIRDLAAVNLDSSLADLGLD 2155
Fly 2183 SLMSAEIKQTLERNFDIVLSAQEIRQLTFGALKAMDGGADVKPAAAAPAAAAGVPEANITSGGSS 2247
||||.|::|||||..::|||.:|:||||...|:.:...||.....|.|
Human 2156 SLMSVEVRQTLERELNLVLSVREVRQLTLRKLQELSSKADEASELACP----------------- 2203
Fly 2248 RTASPMGDG-----TQVVFTTSLIPTE--AIVQLDTKAPANSKQSPIFFISPIEGFASALEPLAK 2305
:|..|| ||:...:.|:..| .:::|:: ..|.:.|:|.:.||||..:....||.
Human 2204 ---TPKEDGLAQQQTQLNLRSLLVNPEGPTLMRLNS---VQSSERPLFLVHPIEGSTTVFHSLAS 2262
Fly 2306 RLEVPAYGLQYTEAVPSDSLESAAKFFIKQLRTVQPKGPYKLAGYSFGCLLTYVMAGILEETNEV 2370
||.:|.||||.|.|.|.||:.|.|.::|..:|.|||:|||::||||:|..:.:.|...|:.....
Human 2263 RLSIPTYGLQCTRAAPLDSIHSLAAYYIDCIRQVQPEGPYRVAGYSYGACVAFEMCSQLQAQQSP 2327
Fly 2371 A----NVIMLDGAPSYVNWYTSSFKQRYTDGTNADNDNQSYGLAYFGIVLANIDYKALVRLLIVI 2431
| ::.:.||:|:||..||.|::.:.|.|..|:.:.:: :.:|.....::::..::..|:.:
Human 2328 APTHNSLFLFDGSPTYVLAYTQSYRAKLTPGCEAEAETEA--ICFFVQQFTDMEHNRVLEALLPL 2390
Fly 2432 PTWEEKLERFAELM--SNEITQPVETIKKSATLFYKKLELADGYQPTLKLKTNVTLVKPTDNSA- 2493
...||::....:|: |::.....| :..:|..||.||..|:.|.|..|...||.|::.....|
Human 2391 KGLEERVAAAVDLIIKSHQGLDRQE-LSFAARSFYYKLRAAEQYTPKAKYHGNVMLLRAKTGGAY 2454
Fly 2494 --KLDEDYRLKEVCTKPVEVHTVEGNHRTFLIEDQSLKTIQSIL 2535
.|..||.|.:||...|.||.:||:||| |:|...|::|.||:
Human 2455 GEDLGADYNLSQVCDGKVSVHVIEGDHRT-LLEGSGLESIISII 2497
| 
