DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FASN1 and F32H2.6

DIOPT Version :9

Sequence 1:	NP_001137778.2	Gene:	FASN1 / 33524	FlyBaseID:	FBgn0283427	Length:	2540	Species:	Drosophila melanogaster
Sequence 2:	NP_492421.1	Gene:	F32H2.6 / 185214	WormBaseID:	WBGene00009343	Length:	187	Species:	Caenorhabditis elegans

Alignment Length:	145	Identity:	56/145 - (38%)
Similarity:	75/145 - (51%)	Gaps:	17/145 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   164 LFDGV-----DMVNDDPRRWERGLYGLPDRIGKLKDSDLENFDQQFFGVHQKQAECMDPLLRMLL 223
            :|.|:     |:|.:|...|..|...||.:.||.|  ||..||........||...|||.:|:||
Worm    30 MFGGMLLACDDVVTEDQLSWAPGFTDLPKKRGKKK--DLNKFDAGILPGTSKQNNPMDPQVRLLL 92

  Fly   224 ELTHEAIIDAGLNPSDLRGSRTGVYIGVSNSETEQHWCSDADRVNGYGLTGC-----ARAMFANR 283
            |.:.||::|||:||..||||:.|.:     .|......|...:.|.....||     ..:||:||
Worm    93 EASWEAMVDAGINPRGLRGSQIGDF-----DECATPGTSGTQKQNPVTEMGCIMSDTVPSMFSNR 152

  Fly   284 ISFTFDFKGPSYSID 298
            ||:|||.:|||:|.|
Worm   153 ISYTFDLQGPSHSAD 167

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FASN1	NP_001137778.2	PksD	137..1142	CDD:225858	56/145 (39%)
		PKS	140..544	CDD:238429	56/145 (39%)
		KAsynt_C_assoc	502..612	CDD:292814
		Acyl_transf_1	633..950	CDD:298668
		hot_dog	990..1234	CDD:294345
		NADB_Rossmann	1358..>1550	CDD:304358
		PKS_ER	1593..1883	CDD:214840
		enoyl_red	1595..1883	CDD:176179
		KR_1_FAS_SDR_x	<1901..2141	CDD:187657
		PKS_PP	2154..>2206	CDD:214834
		Abhydrolase	2286..2535	CDD:304388
F32H2.6	NP_492421.1	ketoacyl-synt	<58..>167	CDD:365879	46/115 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4124
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D19161at2759
OrthoFinder	1	1.000	-	-		FOG0001625
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.870