DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment FASN1 and pks-1

DIOPT Version :9

Sequence 1:NP_001137778.2 Gene:FASN1 / 33524 FlyBaseID:FBgn0283427 Length:2540 Species:Drosophila melanogaster
Sequence 2:NP_508923.2 Gene:pks-1 / 180815 WormBaseID:WBGene00016558 Length:7752 Species:Caenorhabditis elegans


Alignment Length:2802 Identity:568/2802 - (20%)
Similarity:927/2802 - (33%) Gaps:1068/2802 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly    69 DAQLTPSTSSSTPHSAPNDRQDHLNSQFNPESINMPARFAEEVITAEPAQRAAPQLDLGGGHYVP 133
            |.|:| .||:.......:..:||           .|.|.||..|....|....|     ||  |.
 Worm  1860 DPQVT-ETSTGEDDIQKDLTEDH-----------KPTRLAENPIGVMAAACRLP-----GG--VS 1905

  Fly   134 RQQHLNDEIAI-TGFSGRLPESSTIEEFKQNLFDGVDMVNDDPRRWERGLYGLPDRIGKLKDSDL 197
            ....|.:.:.| ...|.|:|  :|....:..|..|             ..||.|...|.....|:
 Worm  1906 SPSELWELLKIGKNASSRIP--ATRVPTRNTLISG-------------SKYGNPVEGGNFITQDV 1955

  Fly   198 ENFDQQFFGVHQKQAECMDPLLRMLLELTHEAIIDAGLNPSDLRGSRTGVYIGVSNSETEQHWCS 262
            ..||..||.:.:.:||.:||..|:|||...|.:.::|:    :..|..||::|:...|.:....|
 Worm  1956 TQFDPSFFKISKSEAELIDPQQRLLLECVQECLENSGV----IETSNVGVFVGLMEKEYQDMMES 2016

  Fly   263 DADRVNGYGLTGCARAMFANRISFTFDFKGPSYSIDTACSSSLYALEQAFSDMREGKVDNALVAG 327
            .:.    ..:.|...|:.|.|:::.|...|||.:|||||||||.|||.|.:.:.:.:....:|||
 Worm  2017 SSI----LAMLGSMAAVIAGRVNYIFGCYGPSVTIDTACSSSLVALEMAINALLDNRCSKVIVAG 2077

  Fly   328 AGLILKPTMSLQFKRLN--MLSPDGSCKAFDESGNGYVRSDGCVVLLLQRTSAARRVYASILNVR 390
            ..|||..  ..|..|.|  |||..|...:||...:||.||||||||:|:.........::|.:|.
 Worm  2078 VNLILNE--KGQGLRTNGKMLSQHGMSLSFDSRASGYGRSDGCVVLMLELAKPNFHYMSTIQSVN 2140

  Fly   391 TNTDGFKEQGITYPIGKMQNRLIRETYEEIGLNPADVV-YVEAHGTGTKVGDPQEVNSITDFFCK 454
            .|..| :...:|.|.|.....|:...   |..:|:..: |.|||||||.:|||.|.|:::...  
 Worm  2141 VNHGG-RSVSLTAPNGVAHKMLLTSV---INQSPSLAIDYWEAHGTGTPLGDPIEFNTLSSIL-- 2199

  Fly   455 DRTTPLLIGSVKSNMGHSEPASGVCSVAKILIAMEEGVIPGNLHYNKPNPDL-YGLVDGRLKVV- 517
               ..::|||||:::||.|.::|.|.:.|:.:.:....:|..:|::..|.|: .|.:  ||.:: 
 Worm  2200 ---QNIIIGSVKASLGHGEASAGTCGLLKLFLMLTYQYVPTLIHFHVLNKDINAGSI--RLPIIG 2259

  Fly   518 -DRNLPWNGGIIGLNSFGFGGANAHVI-LKSNPKPKALTP--KDGALKVVLASGRTFEAVEQLLE 578
             |..|.    ..|::|||..|.||..| ...|.|.:...|  |...|.:...:..:.:.:|:.:.
 Worm  2260 EDSELV----SAGISSFGVSGTNAAAIAFNDNNKLEPYIPIHKYYILPISAKNQISLDNLEKQIL 2320

  Fly   579 SASTNADDDEYLQLINEIHSKAIPN---HF-FRGYGVVSSKGTHQREVIESNDDKRPIWYIYSGM 639
            |.....|    :.:.|  .:.|:.|   || .|...:||:.|     ::.|..:.:|        
 Worm  2321 SVIPLTD----VPICN--IASALANNRSHFTIRNALIVSNSG-----IVNSKMEGKP-------- 2366

  Fly   640 GSQWASMAKDLMKIEAFAKTIQRCADVLKPEGVDLIDVLTRS-TDKSFENILNSFISIAAMQVAL 703
               .....||...:        :..|.|....:...||:..: |..|.:| ..||    ||:.|:
 Worm  2367 ---HRVAKKDRYHV--------KLCDSLLDASLLQYDVINETYTVASLKN-PQSF----AMKFAI 2415

  Fly   704 TDLLSSLGIHPDGIVGHSVGELGCAYADGCFTPEQTVLAAYWRGKSILDTQLAKGKMAAVGLSWE 768
            ...|:||..:.:.:...                          |:.:|...||.|     .|.||
 Worm  2416 IKFLTSLSEYIEIVASD--------------------------GEELLAVLLANG-----SLKWE 2449

  Fly   769 ---------------------DAHSRVPS-----DCFPVCHNSEDNCTISGPEASIEALVAKLNA 807
                                 |.:|...|     ...|..||      :..| ..:..|:.||..
 Worm  2450 NFNKTMIELPIGSLLTEFADHDLNSTTSSSIKSYQTQPESHN------LDSP-MELMKLIMKLYI 2507

  Fly   808 EGVFAKAVNSSGYAFHSKYIAEAGPKLRKSLEKIIPNAK-NRTARWIST-----------SIPES 860
            .|.....  ::.|:...::||             :||.: |:...|...           :|.|.
 Worm  2508 TGYDVDW--ATVYSPVEQFIA-------------LPNYQFNKQTLWFEERLEIVDHYLIGTIDEE 2557

  Fly   861 AWNTPVAKQSSAAYHVNNLLSPVLFHEALQHVPKNAISV-EIAPHGLLQAILKRALGPDATNLSL 924
            :.:|.:.|.     .::.|..|..|    :..|.:..:: |||    ::|:..|           
 Worm  2558 SEDTLILKN-----QISELRHPQFF----KGKPLDVGTMSEIA----IEALKIR----------- 2598

  Fly   925 VKRGHENNVEFFLTNVGKLFAAGAQPQVLTLVRPISYPVGRGTPMLNSKVGWDHTQKWLVAKFGK 989
                  |.:.|.:.|:        :.:::||.:|                      .||      
 Worm  2599 ------NEIPFSIQNL--------KTELITLTKP----------------------AWL------ 2621

  Fly   990 ETSSGETIVEVDLSKEDDAFLAGHTIDGRILFPATGYMTLAWQTFAKMQGSEFHKTPVVMENLVF 1054
            ||:       |..:::|:.|.....|||:.||.                                
 Worm  2622 ETN-------VTRNEDDEGFNVSAYIDGQRLFS-------------------------------- 2647

  Fly  1055 HRATILNKNAVVKFGINFFDGTGAFEICESGSLAVSGKITIPESIDNEELP-LEEQTPSAVA--K 1116
                 ||.::|                                .|.|.|:| :|.|.|..|.  |
 Worm  2648 -----LNASSV--------------------------------EIQNIEVPAVEVQIPDKVVYLK 2675

  Fly  1117 ELGTNDVYKELRLRGYDYGGIFRGIVRSDTVASTGKLQWVDNWISFMDTMLQFSILSKNLREL-- 1179
            |. .|.|.:.           .|.:|..|:.|...                .|...:..|.|:  
 Worm  2676 EC-PNAVIRR-----------HRNMVYVDSRAEQS----------------PFRTANIVLNEIIG 2712

  Fly  1180 YLPTR----IERAVINPAKHFELLSALTKEEQVETGLPVQW---------YSDINVIKSAGVELR 1231
            :.||.    ||...:.|:.|:.:        ||:.|...|:         .|:|.|:|.|    :
 Worm  2713 FAPTPSDMFIEILGVLPSVHYMV--------QVDDGALWQFQMISQDKRVLSNIYVLKDA----K 2765

  Fly  1232 GLKANLAQRRPGTQAPPTLERYQFVPNINTTDLNENSEKARLHALDVAIQVIIENSSGAVKLKGV 1296
            ||:                     :|.|            |:|                   |..
 Worm  2766 GLE---------------------IPTI------------RMH-------------------KKS 2778

  Fly  1297 ELANGRNPDVLVANRLLQIIEGEPVL-TGDVAVVTSNNNEETITAALGDSGVRVVSKDVLKEPVE 1360
            .|.:.:...::.|..|...:..:..| .|||.....:.:|..::....:.|:..::.        
 Worm  2779 TLLSSQEASIVAAKTLQMAVRHKVCLAVGDVIESGLDIDESQLSTGFSELGIDSLAT-------- 2835

  Fly  1361 QNCHFVFGIDVLSRPDTK---TLENSIASIRENGFLI-----LEETL----------PTYTKT-- 1405
                    :|:|:|.:.|   .:|.:.:.:.:|..:|     :|:.|          |...||  
 Worm  2836 --------VDLLNRLNQKYFPEIELTTSDLFDNPSIIDLSIMIEQLLNEKGITEPSEPNTPKTSL 2892

  Fly  1406 -GRALLTKFGFVAVQEQSLGATRVLVLARKAVDLKTRKSVVVVATEQNFNWVDDLKAALATAATE 1469
             ||.|            |:.|.|..|||:             :...:|:|.......|.|.:::.
 Worm  2893 RGRKL------------SIPAVRAQVLAQ-------------IEFVENYNSKQKEVQAEAPSSSS 2932

  Fly  1470 EQYVYVVCQG--EELFGAVGLMTCIKNENGGKLARLVFVQDAKAEKFSLTSTLYRQQLEKDLISN 1532
            |      |..  ||....|.     :.|...|::..||                      ||.:.
 Worm  2933 E------CSNHLEESDATVD-----RTEIRRKVSLAVF----------------------DLATE 2964

  Fly  1533 VLKNGAWGTFRHLKLETQQATLQVEHAYVNALVKGDLASLKWIEAAQADTAATVDKNLETCTVYY 1597
                                ||..|          ||.|..:.|... |:.:.||        :.
 Worm  2965 --------------------TLSAE----------DLQSKGFTELGM-DSLSIVD--------FV 2990

  Fly  1598 APIN---FRDVMLTSGKLAADALPGDLAEQDCVLGLEFAGRDTQGRRVMAMVPAKSLATTCVASK 1659
            ..:|   |.|..:|:..:.......:|::.                    :|..||.:....||:
 Worm  2991 NRLNDKYFPDDEITASDIFDYPTVDELSDH--------------------IVRKKSSSVPPAASE 3035

  Fly  1660 RMMWQIPEKWTMEEASTVPCVYSTVYYALVVRGQMKKGEKILIHAGSGGVGQAAISVALAHGLTV 1724
            .|      |.||...||                                      ||...|    
 Worm  3036 IM------KETMNGIST--------------------------------------SVDAEH---- 3052

  Fly  1725 FTTVGSKEKREFLLKRFPKLQERNIGNSRDTSFEQLVLRETKGRGVDLVLNSLSEEKLQASIRCL 1789
                   .|.|.|.:.|..|:.:   ||.:.:.:.:...:|    :.||..|             
 Worm  3053 -------TKLENLSQSFMLLENQ---NSINPTLKMIWSNQT----IKLVKPS------------- 3090

  Fly  1790 GLNGRFLEIGKFDLSNNSPLGMSVFLKNTSFHGILLDSVMEGEEEMQNQVVSLVAEGIKTGAVVP 1854
              :|.||    |:|:.|......:....|..:.|::|                 .:|...|:...
 Worm  3091 --DGNFL----FELNANGGQEKEIQKHFTGPNNIIID-----------------LKGFHEGSTET 3132

  Fly  1855 LPTSVFNDQQVEQAFRFMASGKHIGKVVIKVR---DEEAGKKALQPKPRLINAIPRTYMH---PE 1913
            |..|:.|            ..|.|.|:.|:.|   .:|.|         |.|:|.|.:|.   .|
 Worm  3133 LYMSLLN------------LVKSISKLEIQCRFGVSQEFG---------LGNSISRAFMKTVAAE 3176

  Fly  1914 K--------------------------SYILVGGLGGFGLELTNWLVTRGARYIVLTSRSGVKTG 1952
            |                          ::::.|||.|.|||:..::...||..::|.||. ..|.
 Worm  3177 KNPLISFAWYQNVQQVSFVDSDSPITGNWLITGGLSGIGLEIGKFIANNGAENVILISRR-QPTA 3240

  Fly  1953 YQGLMIRRWQERGVKVVIDTSDVTTAAGAKKLLENSNKLAL-VGGIFNLAAVLRDALIEDQTAKD 2016
            ........|:.:...:..|.:|      .:||:....||.: :.||.:.|.||:|:.||.|..:.
 Worm  3241 KALREFEHWKSKVHTIAADIND------KEKLIRELTKLNVGITGIIHSAGVLKDSKIERQNKES 3299

  Fly  2017 FKTVADPKVTATKYLDQFSRDICTELDYFICFSSVSCGRGNIGQTNYGLANSAMERICEQRQVSG 2081
            |..|..||......|::..:....:::.||..||.:...||.||.|||::|:.:|...::|:..|
 Worm  3300 FNQVFTPKANGFHVLEEIEKHFNYKIENFIMMSSFTAACGNEGQLNYGVSNAYLEYQVQRRRRQG 3364

  Fly  2082 FPGTAIQWGAIGDTGLV--------LENLG-----DNDTVIGGTLPQRMPSCLQTIDLFLQQPHP 2133
            ..|.|||||...|||:.        |.|||     :.|.:      :.:.:|:      |.:|..
 Worm  3365 KSGCAIQWGNWIDTGMATDENVRKFLANLGFLGQHNKDAL------KYLRACI------LTKPEL 3417

  Fly  2134 V-VASM---VVAEKRK------------------------------------------SDQSAGV 2152
            : ||::   |:.:.||                                          .|:...:
 Worm  3418 IMVANIDWNVILKNRKDLPKDLINTGILPFEDFTGKMNESEFPLSNGDFEKVSMNFSVEDEEEVL 3482

  Fly  2153 SLI-ATIANILGLRDTKNIQDGASLADLGMDSLMSAEIKQTLERNFDI--------------VLS 2202
            .|| ..:::||....|| :::..::.|:|:||.:..|....:...|.|              .|:
 Worm  3483 ELIKEKVSSILMCSPTK-LKNNKNIMDMGLDSKLIVEFLNFINSTFKISVNLSDAYNHPTLEKLA 3546

  Fly  2203 AQEIRQLT-----------------------FG-----------------ALKAMDGGADVKPAA 2227
            |....|:|                       ||                 |:|.::.|..:..|.
 Worm  3547 AHIFEQMTIVDHPVNSVKSEEIFKSTDFCPIFGINIFFDNKNDFDKAKSTAVKLLENGEQLPTAG 3611

  Fly  2228 AAPAAAAGVPEANITSGGSSRTASPM----------------GDGTQV------------VFTTS 2264
            ....:..|....::.|  ..:.|:|.                |.|:|.            :|.|:
 Worm  3612 KYAVSVVGKSIRDVVS--KIKEAAPQQIKLCQESSKCVLMLTGQGSQYPMMGRQLVENYEIFRTT 3674

  Fly  2265 ---------------------LIPTE--AIVQLDTKAPANSKQSPIFFISPIEGFASALEPLAKR 2306
                                 |..|:  .::|| ||     ...||.|..   |:|:|...|:..
 Worm  3675 LQSCLKKCDEYLQGDVSLWEILFNTDHYKLLQL-TK-----HMQPIMFCF---GYATAQLWLSLG 3730

  Fly  2307 LEVPAYGLQYT--EAVPS-----DSLESAAKFFIKQLRTVQPKGPYKLAGYSFGCLLTYVMAGIL 2364
            : ||.|.|.::  |.|..     .|:|...:..:::.:.::     .:||  .|.||. |...|.
 Worm  3731 I-VPDYYLGHSVGELVAGVLAGIMSIEDGLRLIVERGKAME-----NIAG--LGALLA-VQREIA 3786

  Fly  2365 EET-----------NEVANVI------MLDGAPSYVNWYTSSFKQRYTDGTNADNDNQSYGLAYF 2412
            :|.           |....|:      :||.|.::|.          ..|..|...||.|     
 Worm  3787 DEVLRKFKVSVATINSPKQVVFAGTKSVLDAALAFVK----------GQGKQATYVNQQY----- 3836

  Fly  2413 GIVLANIDYKALVRLLIVIPTWEEKLERFAELMSNEITQPVETIKKSATLFYKKLELADGYQPTL 2477
                                .:...|.:...|:|  :.|.:..||.||           |..|  
 Worm  3837 --------------------PFHSNLIQETHLVS--LRQCLADIKFSA-----------GRTP-- 3866

  Fly  2478 KLKTNVT-----------LVKPTDNSAKLDEDYRLKEVCTKPVEVHTVEGNHRTFLIEDQSLKTI 2531
             |.:|||           :||.|.::.|..:       |     |.|::....|..|:..|...:
 Worm  3867 -LVSNVTGQIINTFSEAYIVKHTVSAVKFVD-------C-----VETLQAKGVTVWIDAGSAAVL 3918

  Fly  2532 QSILKRL 2538
            .:.:||:
 Worm  3919 ATFVKRI 3925

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FASN1NP_001137778.2 PksD 137..1142 CDD:225858 240/1061 (23%)
PKS 140..544 CDD:238429 130/411 (32%)
KAsynt_C_assoc 502..612 CDD:292814 29/119 (24%)
Acyl_transf_1 633..950 CDD:298668 59/356 (17%)
hot_dog 990..1234 CDD:294345 48/261 (18%)
NADB_Rossmann 1358..>1550 CDD:304358 36/214 (17%)
PKS_ER 1593..1883 CDD:214840 47/292 (16%)
enoyl_red 1595..1883 CDD:176179 47/290 (16%)
KR_1_FAS_SDR_x <1901..2141 CDD:187657 76/286 (27%)
PKS_PP 2154..>2206 CDD:214834 15/66 (23%)
Abhydrolase 2286..2535 CDD:304388 58/283 (20%)
pks-1NP_508923.2 PKS 13..394 CDD:238429
PKS_KS 57..395 CDD:214836
KAsynt_C_assoc <376..>433 CDD:292814
PP-binding 736..799 CDD:278949
PKS_KS 830..1197 CDD:214836
PKS 830..1197 CDD:238429
hot_dog 1544..1759 CDD:294345
PKS_PP <1806..1857 CDD:214834
PKS 1889..2282 CDD:238429 136/439 (31%)
PKS_KS 1891..2282 CDD:214836 136/437 (31%)
PKS_PP 2790..2867 CDD:214834 15/92 (16%)
PKS_PP 2943..3024 CDD:214834 23/166 (14%)
PKS_KR 3203..3377 CDD:214833 55/180 (31%)
PP-binding 3485..3549 CDD:278949 14/64 (22%)
PksD <3609..3984 CDD:225858 76/400 (19%)
PKS_AT 3649..3927 CDD:214838 71/358 (20%)
hot_dog 3994..4216 CDD:294345
PKS 4290..4628 CDD:238429
PRK14691 4335..4629 CDD:173154
NADB_Rossmann <4991..5131 CDD:304358
PP-binding 5168..5230 CDD:278949
PKS 5258..5645 CDD:238429
PKS_KS 5260..5646 CDD:214836
KAsynt_C_assoc <5628..>5693 CDD:292814
Acyl_transf_1 5761..6023 CDD:298668
NADB_Rossmann <6237..6393 CDD:304358
PP-binding 6476..6539 CDD:278949
Condensation 6558..6831 CDD:305010
AFD_class_I 6990..7412 CDD:302604
AA-adenyl-dom 7000..7356 CDD:273779
PP-binding 7436..7499 CDD:278949
Abhydrolase 7527..>7622 CDD:304388
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D19161at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.920

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