back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FASN1 and Fasn

DIOPT Version :9

Sequence 1:	NP_001137778.2	Gene:	FASN1 / 33524	FlyBaseID:	FBgn0283427	Length:	2540	Species:	Drosophila melanogaster
Sequence 2:	NP_032014.3	Gene:	Fasn / 14104	MGIID:	95485	Length:	2504	Species:	Mus musculus

Alignment Length:	2556	Identity:	1128/2556 - (44%)
Similarity:	1581/2556 - (61%)	Gaps:	227/2556 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   140 DEIAITGFSGRLPESSTIEEFKQNLFDGVDMVNDDPRRWERGLYGLPDRIGKLKDSDLENFDQQF 204
            :|:.|.|.||:||||..::||..||..|||||.||.|||:.||||||.|.||||  ||..||..|
Mouse     2 EEVVIAGMSGKLPESENLQEFWANLIGGVDMVTDDDRRWKAGLYGLPKRSGKLK--DLSKFDASF 64

  Fly   205 FGVHQKQAECMDPLLRMLLELTHEAIIDAGLNPSDLRGSRTGVYIGVSNSETEQHWCSDADRVNG 269
            ||||.|||..|||.||:|||:::|||:|.|:||:.|||:.|||::|||.||..:....|.:.:.|
Mouse    65 FGVHPKQAHTMDPQLRLLLEVSYEAIVDGGINPASLRGTNTGVWVGVSGSEASEALSRDPETLLG 129

  Fly   270 YGLTGCARAMFANRISFTFDFKGPSYSIDTACSSSLYALEQAFSDMREGKVDNALVAGAGLILKP 334
            |.:.||.|||.|||:||.|||||||.::||||||||.||:.|:..:|.|:...|||.|..|:|||
Mouse   130 YSMVGCQRAMMANRLSFFFDFKGPSIALDTACSSSLLALQNAYQAIRSGECPAALVGGINLLLKP 194

  Fly   335 TMSLQFKRLNMLSPDGSCKAFDESGNGYVRSDGCVVLLLQRTSAARRVYASILNVRTNTDGFKEQ 399
            ..|:||.:|.||||||:|::||:||:||.||:..|.:||.:.|.||||||:|||..|||||.|||
Mouse   195 NTSVQFMKLGMLSPDGTCRSFDDSGSGYCRSEAVVAVLLTKKSLARRVYATILNAGTNTDGSKEQ 259

  Fly   400 GITYPIGKMQNRLIRETYEEIGLNPADVVYVEAHGTGTKVGDPQEVNSITDFFCKDRTTPLLIGS 464
            |:|:|.|::|.:||...|:..||.|..:.|:||||||||||||||:|.||...|..|..||||||
Mouse   260 GVTFPSGEVQEQLICSLYQPAGLAPESLEYIEAHGTGTKVGDPQELNGITRSLCAFRQAPLLIGS 324

  Fly   465 VKSNMGHSEPASGVCSVAKILIAMEEGVIPGNLHYNKPNPDLYGLVDGRLKVVDRNLPWNGGIIG 529
            .||||||.|||||:.::.|:|:::|.||...|||::.|||::..|:||||:||||.||..||.:|
Mouse   325 TKSNMGHPEPASGLAALTKVLLSLEHGVWAPNLHFHNPNPEIPALLDGRLQVVDRPLPVRGGNVG 389

  Fly   530 LNSFGFGGANAHVILKSNPKPKALTPKDGALKVVL-ASGRTFEAVEQLLESASTNADDDEYLQLI 593
            :|||||||:|.||||:.|.:.........||..:| |||||.|||:.|||....::.|..::.::
Mouse   390 INSFGFGGSNVHVILQPNTRQAPAPTAHAALPHLLHASGRTLEAVQDLLEQGRQHSQDLAFVSML 454

  Fly   594 NEI---HSKAIPNHFFRGYGVVSSKGTHQREVIESNDDKRPIWYIYSGMGSQWASMAKDLMKIEA 655
            |:|   .:.|:|   ||||.|:..:|..| ||.:.:.:|||:|:|.||||:||..|...||::::
Mouse   455 NDIAATPTAAMP---FRGYTVLGVEGRVQ-EVQQVSTNKRPLWFICSGMGTQWRGMGLSLMRLDS 515

  Fly   656 FAKTIQRCADVLKPEGVDLIDVLTRSTDKSFENILNSFISIAAMQVALTDLLSSLGIHPDGIVGH 720
            |.::|.|..:.:||.||.:.|:|..:.:::|::|:::|:|:.|:|:||.|||:|:|:.||||:||
Mouse   516 FRESILRSDEAVKPLGVKVSDLLLSTDERTFDDIVHAFVSLTAIQIALIDLLTSVGLKPDGIIGH 580

  Fly   721 SVGELGCAYADGCFTPEQTVLAAYWRGKSILDTQLAKGKMAAVGLSWEDAHSRVPSDCFPVCHNS 785
            |:||:.|.|||||.:..:.||||||||:.|.|..|..|.|||||||||:...|.|:...|.||||
Mouse   581 SLGEVACGYADGCLSQREAVLAAYWRGQCIKDAHLPPGSMAAVGLSWEECKQRCPAGVVPACHNS 645

  Fly   786 EDNCTISGPEASIEALVAKLNAEGVFAKAVNSSGYAFHSKYIAEAGPKLRKSLEKIIPNAKNRTA 850
            ||..|||||:|::...|.:|..||||||.|.:.|.||||.::....|.|.::|:|:|...:.|:|
Mouse   646 EDTVTISGPQAAVNEFVEQLKQEGVFAKEVRTGGLAFHSYFMEGIAPTLLQALKKVIREPRPRSA 710

  Fly   851 RWISTSIPESAWNTPVAKQSSAAYHVNNLLSPVLFHEALQHVPKNAISVEIAPHGLLQAILKRAL 915
            ||:||||||:.|.:.:|:.|||.|:||||:|||||.|||.|:|::|:.:|||||.||||:|||.:
Mouse   711 RWLSTSIPEAQWQSSLARTSSAEYNVNNLVSPVLFQEALWHIPEHAVVLEIAPHALLQAVLKRGV 775

  Fly   916 GPDATNLSLVKRGHENNVEFFLTNVGKLFAAGAQPQVLTLVRPISYPVGRGTPMLNSKVGWDHTQ 980
            ....|.:.|:||.|::|:||||||:||:...|.......|..|:.:|..||||:::..:.|||:|
Mouse   776 KSSCTIIPLMKRDHKDNLEFFLTNLGKVHLTGINVNPNALFPPVEFPAPRGTPLISPHIKWDHSQ 840

  Fly   981 KW---LVAKF-GKETSSGETIVEVDLSKED-DAFLAGHTIDGRILFPATGYMTLAWQTFAKMQGS 1040
            .|   :...| ...:||..|:..:|.|.|. |.:|..|.||||::||.|||:.|.|:|.|:..|.
Mouse   841 TWDVPVAEDFPNGSSSSSATVYSIDASPESPDHYLVDHCIDGRVIFPGTGYLCLVWKTLARSLGL 905

  Fly  1041 EFHKTPVVMENLVFHRATILNKNAVVKFGINFFDGTGAFEICESGSLAVSGKITI---PES--ID 1100
            ...:||||.||:.||:||||.|...|...:...:.:.|||:.::|:|.||||:.:   |.|  .|
Mouse   906 SLEETPVVFENVSFHQATILPKTGTVALEVRLLEASHAFEVSDTGNLIVSGKVYLWEDPNSKLFD 970

  Fly  1101 NEELPLEEQTP--SAVAKELGTNDVYKELRLRGYDYGGIFRGIVRSDTVASTGKLQWVDNWISFM 1163
            :.|:|    ||  ||....|...:|||||||||||||..|:||..:......|||.|.|||::||
Mouse   971 HPEVP----TPPESASVSRLTQGEVYKELRLRGYDYGPQFQGICEATLEGEQGKLLWKDNWVTFM 1031

  Fly  1164 DTMLQFSILSKNLRELYLPTRIERAVINPAKHFELLSALTKEEQVETGLPVQWYSDINVIKSAGV 1228
            |||||.|||..:.:.|.||||:....|:||.|.:.:..|.::.||   ..|.....:.:..|.|:
Mouse  1032 DTMLQVSILGSSQQSLQLPTRVTAIYIDPATHRQKVYRLKEDTQV---ADVTTSRCLGITVSGGI 1093

  Fly  1229 ELRGLKANLAQRRPGTQAPPTLERYQFVPNINTTDLNENSE------------------------ 1269
            .:..|:.....||...|..||||::.|.|::....|:|::.
Mouse  1094 HISRLQTTATSRRQQEQLVPTLEKFVFTPHMEAECLSESTALQKELQLCKGLARALQTKATQQGL 1158

  Fly  1270 KARL------------------------------------------------------HALDVAI 1280
            ||.:                                                      .||...:
Mouse  1159 KAAMLGQEDPPQHGLPRLLAAACQLQLNGNLQLELGEALAQERLLLPEDPLISGLLNSQALKACV 1223

  Fly  1281 QVIIENSSGAVKLKGVELANGRNPDVLVANRLLQIIEGEPVLTGDVAVVTSNNNEETIT----AA 1341
            ...:||.| .:|:|..|:..|...   :.:|:..::..:|:|          ..|.|.|    .|
Mouse  1224 DTALENLS-TLKMKVAEVLAGEGH---LYSRIPALLNTQPML----------QLEYTATDRHPQA 1274

  Fly  1342 LGDSGVRVVSKDVLK------EPVEQ----------NCHFVFGIDVLSRPDTKTLENSIASIREN 1390
            |.|...::...||.:      :|...          ||    .:..|..| ...|:|.:|:::|.
Mouse  1275 LKDVQTKLQQHDVAQGQWNPSDPAPSSLGALDLLVCNC----ALATLGDP-ALALDNMVAALKEG 1334

  Fly  1391 GFLI---------LEET---LPTYTKTGRALLTK-----------FGFVAVQEQSLGATRVLVLA 1432
            |||:         |.||   ||:..:...:||::           ...|.::....|.  .|.|.
Mouse  1335 GFLLVHTVLKGHALGETLACLPSEVQPAPSLLSQEEWESLFSRKALHLVGLKRSFYGT--ALFLC 1397

  Fly  1433 RKAVDLKTRKSVVVVATEQNFNWVDDLKAALATAATEEQYVYVVCQGEELFGAVGLMTCIKNENG 1497
            |:|:  ...|.:.:...:.:|.|||.||:.|||:::  |.|::........|.|||:.|::.|.|
Mouse  1398 RRAI--PQEKPIFLSVEDTSFQWVDSLKSTLATSSS--QPVWLTAMDCPTSGVVGLVNCLRKEPG 1458

  Fly  1498 GKLARLVFVQD----AKAEKFSLTSTLYRQQLEKDLISNVLKNGAWGTFRHLKLETQQATLQVEH 1558
            |...|.:.:.:    :.|.|....|...:|.|:.||:.||.::||||.|||.:||..:...|..|
Mouse  1459 GHRIRCILLSNLSNTSHAPKLDPGSPELQQVLKHDLVMNVYRDGAWGAFRHFQLEQDKPKEQTAH 1523

  Fly  1559 AYVNALVKGDLASLKWIEAAQADTAATVDKNLETCTVYYAPINFRDVMLTSGKLAADALPGDLAE 1623
            |:||.|.:|||||::|:.:....|..: ....:.||||||.:||||:||.:|||:.||:||..|.
Mouse  1524 AFVNVLTRGDLASIRWVSSPLKHTQPS-SSGAQLCTVYYASLNFRDIMLATGKLSPDAIPGKWAS 1587

  Fly  1624 QDCVLGLEFAGRDTQGRRVMAMVPAKSLATTCVASKRMMWQIPEKWTMEEASTVPCVYSTVYYAL 1688
            :||:||:||:|||..|||||.:|||:.|||:.:.|...:|.:|..||:|||::||.||:|.||:|
Mouse  1588 RDCMLGMEFSGRDRCGRRVMGLVPAEGLATSVLLSSDFLWDVPSSWTLEEAASVPVVYTTAYYSL 1652

  Fly  1689 VVRGQMKKGEKILIHAGSGGVGQAAISVALAHGLTVFTTVGSKEKREFLLKRFPKLQERNIGNSR 1753
            ||||::::||.:|||:|||||||||||:||:.|..|||||||.|||.:|..|||:|.:.:..|||
Mouse  1653 VVRGRIQRGETVLIHSGSGGVGQAAISIALSLGCRVFTTVGSAEKRAYLQARFPQLDDTSFANSR 1717

  Fly  1754 DTSFEQLVLRETKGRGVDLVLNSLSEEKLQASIRCLGLNGRFLEIGKFDLSNNSPLGMSVFLKNT 1818
            ||||||.||..|.|:|||||||||:|||||||:|||..:||||||||||||||.||||::||||.
Mouse  1718 DTSFEQHVLLHTGGKGVDLVLNSLAEEKLQASVRCLAQHGRFLEIGKFDLSNNHPLGMAIFLKNV 1782

  Fly  1819 SFHGILLDSVMEGEEEMQNQVVSLVAEGIKTGAVVPLPTSVFNDQQVEQAFRFMASGKHIGKVVI 1883
            :|||||||::.|...:...:|.:|:..||:.|.|.||..:||...|||.|||:||.|||||||::
Mouse  1783 TFHGILLDALFEEANDSWREVAALLKAGIRDGVVKPLKCTVFPKAQVEDAFRYMAQGKHIGKVLV 1847

  Fly  1884 KVRDEEAGKKALQP--KPRLINAIPRTYMHPEKSYILVGGLGGFGLELTNWLVTRGARYIVLTSR 1946
            :||:||  .:|:.|  :|.||:||.:|:....||||:.||||||||||..|||.|||:.:|||||
Mouse  1848 QVREEE--PEAVLPGAQPTLISAISKTFCPAHKSYIITGGLGGFGLELARWLVLRGAQRLVLTSR 1910

  Fly  1947 SGVKTGYQGLMIRRWQERGVKVVIDTSDVTTAAGAKKLLENSNKLALVGGIFNLAAVLRDALIED 2011
            ||::||||...||.|:.:|::|::.||:|::..||:.|:..:.||..|||:||||.|||||::|:
Mouse  1911 SGIRTGYQAKHIREWRRQGIQVLVSTSNVSSLEGARALIAEATKLGPVGGVFNLAMVLRDAMLEN 1975

  Fly  2012 QTAKDFKTVADPKVTATKYLDQFSRDICTELDYFICFSSVSCGRGNIGQTNYGLANSAMERICEQ 2076
            ||.:.|:.|..||...|..||:.:|:.|.|||||:.||||||||||.||||||.|||.|||||||
Mouse  1976 QTPELFQDVNKPKYNGTLNLDRATREACPELDYFVAFSSVSCGRGNAGQTNYGFANSTMERICEQ 2040

  Fly  2077 RQVSGFPGTAIQWGAIGDTGLVLENLGDNDTVIGGTLPQRMPSCLQTIDLFLQQPHPVVASMVVA 2141
            |:..|.||.|:|||||||.|:|||.:|.||||||||||||:.||::.:||||.|||.|::|.|:|
Mouse  2041 RRHDGLPGLAVQWGAIGDVGIVLEAMGTNDTVIGGTLPQRISSCMEVLDLFLNQPHAVLSSFVLA 2105

  Fly  2142 EKR---KSDQSAGVSLIATIANILGLRDTKNIQDGASLADLGMDSLMSAEIKQTLERNFDIVLSA 2203
            ||:   ..|......|:..:|:|||:||...|...::|||||:||||..|::|.|||..|:||..
Mouse  2106 EKKAVAHGDGDTQRDLVKAVAHILGIRDLAGINLDSTLADLGLDSLMGVEVRQILEREHDLVLPM 2170

  Fly  2204 QEIRQLTFGALKAMDGGADVKPAAAAPAAAAGVPEANITSGGSSRTASPMGDGTQVVFTTSLIPT 2268
            :|:||||...|:.|....|               .|..|:...||:.:.:.. .|:..:|.|:..
Mouse  2171 REVRQLTLRKLQEMSSKTD---------------SATDTTAPKSRSDTSLKQ-NQLNLSTLLVNP 2219

  Fly  2269 E--AIVQLDTKAPANSKQSPIFFISPIEGFASALEPLAKRLEVPAYGLQYTEAVPSDSLESAAKF 2331
            |  .:.||::   ..|.:.|:|.:.||||..:....||.:|.||.||||.|:|.|.||:.:.|.:
Mouse  2220 EGPTLTQLNS---VQSSERPLFLVHPIEGSTTVFHSLAAKLSVPTYGLQCTQAAPLDSIPNLAAY 2281

  Fly  2332 FIKQLRTVQPKGPYKLAGYSFGCLLTYVMAGILEETNEVA----NVIMLDGAPSYVNWYTSSFKQ 2392
            :|..::.|||:|||::||||||..:.:.|...|:.....|    |:.:.||:.:||..||.|::.
Mouse  2282 YIDCIKQVQPEGPYRIAGYSFGACVAFEMCSQLQAQQGPAPTHNNLFLFDGSHTYVLAYTQSYRA 2346

  Fly  2393 RYTDGTNADNDNQSYGLAYFGIVLANIDYKALVRLLIVIPTWEEKLERFAELMSNEITQPVETIK 2457
            :.|.|..|:.:.::  |.:|.....::::..::..|:.:.:.|:::....:|    ||:...::.
Mouse  2347 KMTPGCEAEAEAEA--LCFFIKQFLDVEHSKVLEALLPLKSLEDRVAASVDL----ITKSHHSLD 2405

  Fly  2458 K-----SATLFYKKLELADGYQPTLKLKTNVTLVKPTDNSA---KLDEDYRLKEVCTKPVEVHTV 2514
            :     :|..||.||..||.|:|..|...||||::......   .|..||.|.:||...|.||.:
Mouse  2406 RRELSFAAVSFYHKLRAADQYKPKAKYHGNVTLLRAKTGGTYGEDLGADYNLSQVCDGKVSVHII 2470

  Fly  2515 EGNHRTFLIEDQSLKTIQSIL 2535
            ||:||| |:|...|::|.:|:
Mouse  2471 EGDHRT-LLEGSGLESIINII 2490

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.