DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment FASN1 and fasn

DIOPT Version :9

Sequence 1:NP_001137778.2 Gene:FASN1 / 33524 FlyBaseID:FBgn0283427 Length:2540 Species:Drosophila melanogaster
Sequence 2:XP_031750124.1 Gene:fasn / 100487052 XenbaseID:XB-GENE-1002983 Length:2510 Species:Xenopus tropicalis


Alignment Length:2553 Identity:1111/2553 - (43%)
Similarity:1568/2553 - (61%) Gaps:215/2553 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly   140 DEIAITGFSGRLPESSTIEEFKQNLFDGVDMVNDDPRRWERGLYGLPDRIGKLKDSDLENFDQQF 204
            ::|.|.|.|||||||:.::||..||..|||||.:|.|||:.||||||.|.||||  :|:.||..|
 Frog     2 EDIVIAGMSGRLPESNNLQEFWDNLIQGVDMVTEDDRRWKPGLYGLPKRNGKLK--ELDKFDAAF 64

  Fly   205 FGVHQKQAECMDPLLRMLLELTHEAIIDAGLNPSDLRGSRTGVYIGVSNSETEQHWCSDADRVNG 269
            ||||.|||..|||.||:|||:.:|||:|||:||::|||:.|||::|||.||..:.:..|.:.:.|
 Frog    65 FGVHPKQAHTMDPQLRLLLEICYEAIVDAGINPNELRGTNTGVWVGVSGSEAGEAFSRDPEELLG 129

  Fly   270 YGLTGCARAMFANRISFTFDFKGPSYSIDTACSSSLYALEQAFSDMREGKVDNALVAGAGLILKP 334
            |.:|||.|||||||||:.|:|||||.||||||||||.|||.|:..::.|:.:.|:|||..::|||
 Frog   130 YSMTGCQRAMFANRISYFFNFKGPSLSIDTACSSSLLALENAYKAIQHGQCNAAIVAGVNVLLKP 194

  Fly   335 TMSLQFKRLNMLSPDGSCKAFDESGNGYVRSDGCVVLLLQRTSAARRVYASILNVRTNTDGFKEQ 399
            ..|:||.:|.||||||:||:||.|||||.||:..|.:|:.:.|.|:|:|::|||..:||||||||
 Frog   195 NTSVQFMKLGMLSPDGACKSFDASGNGYCRSEAAVAVLVTKKSLAKRLYSTILNAGSNTDGFKEQ 259

  Fly   400 GITYPIGKMQNRLIRETYEEIGLNPADVVYVEAHGTGTKVGDPQEVNSITDFFCKDRTTPLLIGS 464
            |:|:|.|.:|..|:...|:|.|::|:.|.|:||||||||||||||||.|....|.....||||||
 Frog   260 GVTFPSGAVQQELLTSLYKEAGIHPSQVEYLEAHGTGTKVGDPQEVNGIVGVLCDSTREPLLIGS 324

  Fly   465 VKSNMGHSEPASGVCSVAKILIAMEEGVIPGNLHYNKPNPDLYGLVDGRLKVVDRNLPWNGGIIG 529
            .||||||.|||||:.::||:::::|.||...||||..||.|:..|.|||::||.:..|..|||:|
 Frog   325 TKSNMGHPEPASGLAALAKVILSLEHGVWAPNLHYETPNSDIPALQDGRIQVVTKPTPVKGGIVG 389

  Fly   530 LNSFGFGGANAHVILKSNPKPKALTPKDGAL----KVVLASGRTFEAVEQLLESASTNADDDEYL 590
            :|||||||:|.|:|||.|.|    .|.|.|.    ::|||.|||.:|||.:::.:...|.|:.::
 Frog   390 INSFGFGGSNVHIILKPNEK----KPSDVASVEFPRLVLACGRTEKAVESIIQKSREPAADNTFV 450

  Fly   591 QLINEIHSKAIPNHF--FRGYGVVSSKGTHQREVIESNDDKRPIWYIYSGMGSQWASMAKDLMKI 653
            .|:|:|  ..||...  :||| .::...:..:|:.::....||:|||.||||:||..|...|||:
 Frog   451 TLLNDI--SGIPQSSMPYRGY-TLAKTDSDIKEIQQAQVSGRPLWYICSGMGTQWKGMGHSLMKL 512

  Fly   654 EAFAKTIQRCADVLKPEGVDLIDVLTRSTDKSFENILNSFISIAAMQVALTDLLSSLGIHPDGIV 718
            :.|.::|.|..:.||..|:.:.::|..:.|::||:.|::|:.:||:|||..|:|.::.:.|||||
 Frog   513 DIFRQSILRSDEALKGTGLKVSELLLNADDRTFEDTLHAFVGLAAIQVAQIDMLKAMKLEPDGIV 577

  Fly   719 GHSVGELGCAYADGCFTPEQTVLAAYWRGKSILDTQLAKGKMAAVGLSWEDAHSRVPSDCFPVCH 783
            |||||||.|.|||...:..:.:|||||||:.|.:..|..|.||||||:|.:...:.|....|.||
 Frog   578 GHSVGELACGYADNSLSQNEAILAAYWRGRCIKEAHLPPGGMAAVGLTWAECKIQCPKGVVPACH 642

  Fly   784 NSEDNCTISGPEASIEALVAKLNAEGVFAKAVNSSGYAFHSKYIAEAGPKLRKSLEKIIPNAKNR 848
            ||||..|||||:.|:...|..|.::|||||.|.|:|.||||.|:....|.|..:|:||| ..|.|
 Frog   643 NSEDTVTISGPQDSVREFVGSLKSKGVFAKEVQSAGVAFHSYYMESIAPSLLNALKKII-TPKPR 706

  Fly   849 TARWISTSIPESAWNTPVAKQSSAAYHVNNLLSPVLFHEALQHVPKNAISVEIAPHGLLQAILKR 913
            ::||:|||||||.||:.:||.|||.||||||:|||||.|.||::|:||:.||||||.||||:|:|
 Frog   707 SSRWVSTSIPESQWNSNLAKFSSAEYHVNNLVSPVLFQEGLQNIPENAVVVEIAPHALLQAVLRR 771

  Fly   914 ALGPDATNLSLVKRGHENNVEFFLTNVGKLFAAGAQPQVLTLVRPISYPVGRGTPMLNSKVGWDH 978
            :|.|..|.|.|:|:||.||:||||||:||::..|...:...:...:.||...||.:::..:.|||
 Frog   772 SLKPTNTILPLMKKGHSNNLEFFLTNIGKVYMNGINVEANNIFPSVEYPAPAGTSLISPLIMWDH 836

  Fly   979 TQKWLVAK-----FGKETSSGETIVEVDLSKED-DAFLAGHTIDGRILFPATGYMTLAWQTFAKM 1037
            :|.|.|.|     .|...|:..|:..:|::.:. |.|:.||.||||:|:|||||:.|||:|.|:.
 Frog   837 SQTWDVPKAEDFPAGSGGSTATTVYNIDMNPDSPDLFMNGHCIDGRVLYPATGYLVLAWRTLARS 901

  Fly  1038 QGSEFHKTPVVMENLVFHRATILNKNAVVKFGINFFDGTGAFEICESGSLAVSGKITIPE----- 1097
            .|....:|||:.|::..||||||.|..:::..:.....:..||:.|:|||..||||::.|     
 Frog   902 LGIVMEQTPVIFEDVTIHRATILPKTGIIQMEVRLMPASKRFEVSENGSLTASGKISVMEENVLN 966

  Fly  1098 --------SIDNEELPLEEQTPSAVAKELGTNDVYKELRLRGYDYGGIFRGIVRSDTVASTGKLQ 1154
                    |:|.:| .::.:.|      |...|:||||||||||||..|:||:.|::....|||.
 Frog   967 NFQNQLMDSLDKDE-DIDSELP------LSDRDIYKELRLRGYDYGPSFQGIIESNSRGDKGKLL 1024

  Fly  1155 WVDNWISFMDTMLQFSILSKNLRELYLPTRIERAVINPAKHFELLSALTKEEQVETGLPVQWYSD 1219
            |..||::|.|||||..:|....|.|.|||||....|:|..|.:.:.....:.:   .:.|...|.
 Frog  1025 WSGNWVTFTDTMLQMMVLGLKGRSLRLPTRILSVGIDPTIHKDHVFLHNGDRE---AVHVAVNSC 1086

  Fly  1220 INVIKSAGVELRGLKANLAQRRPGTQAPPTLERYQFVPNINTTDLNENSE--------------- 1269
            ::.|.:.||::.||.|..|.||...|.||.||::.|.|......|::|.:               
 Frog  1087 LDRIVAGGVQILGLHATTAPRRQQQQTPPILEKFVFTPYFEEKCLSDNHDLHYQLQQCSGKIRDL 1151

  Fly  1270 --KARLHALDVAI------QVIIENSSGAVKLKGV-----ELANGRNPDVLVANRLLQIIE---- 1317
              |...|.|.:.|      :...|.:......||:     |:.|......|.::..|.:|:    
 Frog  1152 ESKLSQHGLKLEIPEFNVPEPTNEGTKSDALNKGLLHVLTEICNLELNGNLQSDLELMLIKEKDQ 1216

  Fly  1318 --GEPVLTG-----------DVAVVTSNNNEETITAALGDSG-----------------VRVVSK 1352
              .:|:|.|           |:.:...|..:..|...|.::|                 :..::.
 Frog  1217 LRNDPLLNGLLDSPQLKTCLDIVLENGNPQQMKIVEVLAETGRLFSYVPTLLNTQPMLQLDYIAT 1281

  Fly  1353 DVLKE---PVEQNCHFVFGIDVL------SRPDTKT--------------------LENSIASIR 1388
            |...|   .:|:|.. .||:.|.      :.|:|.|                    ..|..|:::
 Frog  1282 DSTTEVLLSLEENLK-EFGVSVEQWDPLGTAPNTVTNADLLVCNSSLHLLKNPLQAFTNMAATVK 1345

  Fly  1389 ENGFLILEETL------PTYT-------KTGRALLTK-----------FGFVAVQEQSLGATRVL 1429
            |.||::|...|      .|.|       :....||::           ...:|:::....:  |:
 Frog  1346 EGGFILLHTLLKGDMLGETITFLNNQNPQQNEGLLSQTEWKEVFDGASLNLIAMKKSFYNS--VI 1408

  Fly  1430 VLARKAVDLKTRKSVVVVATEQNFNWVDDLKAALATAATEEQYVYVVCQGEELFGAVGLMTCIKN 1494
            .|.|:.|..:|  .:.:...:....||..::.|:|.:.  ||.::.|.:.:...|.||::.|::.
 Frog  1409 FLCRRQVPEQT--PLFLSVEDMACTWVKSVQEAMADSG--EQTIWFVAENQANSGTVGMVNCLRQ 1469

  Fly  1495 ENGGKLARLVFVQDAKAEKFSLTSTLYRQQLEKDLISNVLKNGAWGTFRHLKLETQQATLQVEHA 1559
            |.|||..|.:|..||:|:  .|:....:|||..||:.||.::|.||:|||:.........:...|
 Frog  1470 EPGGKRIRCIFNADAEAK--PLSEKEKKQQLTNDLVMNVYRDGEWGSFRHIPFHKDGIQDETAFA 1532

  Fly  1560 YVNALVKGDLASLKWIEAAQADTAATVDKNLETCTVYYAPINFRDVMLTSGKLAADALPGDLAEQ 1624
            :||.|.:|||::|.|: |:........:.|::.|.||||.:||||:||.:|||..||:|||||.|
 Frog  1533 FVNILTRGDLSTLSWV-ASPLQHFLPSNPNVQLCKVYYASLNFRDIMLATGKLPPDAIPGDLALQ 1596

  Fly  1625 DCVLGLEFAGRDTQGRRVMAMVPAKSLATTCVASKRMMWQIPEKWTMEEASTVPCVYSTVYYALV 1689
            .|:||:||:|||..|:|||.::|||.|||...|.:|.:|.:||.|::|||::||.||:|.|||||
 Frog  1597 QCMLGMEFSGRDPAGKRVMGLLPAKGLATAVDADQRFLWDVPESWSLEEAASVPVVYATAYYALV 1661

  Fly  1690 VRGQMKKGEKILIHAGSGGVGQAAISVALAHGLTVFTTVGSKEKREFLLKRFPKLQERNIGNSRD 1754
            |||:::|||.:|||:||||||||||::||:.|..||.||||.:|||:|..||.:|......||||
 Frog  1662 VRGRIRKGESVLIHSGSGGVGQAAIAIALSMGCQVFITVGSSQKREYLQNRFTELDANCFANSRD 1726

  Fly  1755 TSFEQLVLRETKGRGVDLVLNSLSEEKLQASIRCLGLNGRFLEIGKFDLSNNSPLGMSVFLKNTS 1819
            |||||.:|..|.|:||||:||||:|||||||:|||..:||||||||:||||||||||::||||.|
 Frog  1727 TSFEQHILSRTGGKGVDLILNSLAEEKLQASLRCLARHGRFLEIGKYDLSNNSPLGMALFLKNVS 1791

  Fly  1820 FHGILLDSVMEGEEEMQNQVVSLVAEGIKTGAVVPLPTSVFNDQQVEQAFRFMASGKHIGKVVIK 1884
            |||||||::.|.:.:...:|..|:..|||.|.|.||..:||....||.||||||.|||||||:||
 Frog  1792 FHGILLDALFEDQNKEWEEVSDLLKAGIKDGVVKPLKCTVFERDDVEPAFRFMAQGKHIGKVLIK 1856

  Fly  1885 VRDEEAGK----KALQPKPRLINAIPRTYMHPEKSYILVGGLGGFGLELTNWLVTRGARYIVLTS 1945
            ||||||.:    ..||     |:|||||.....||||:.||||||||||..||:.|||:.:||||
 Frog  1857 VRDEEAEQHYKSDILQ-----ISAIPRTSFPSTKSYIITGGLGGFGLELAQWLIERGAKNLVLTS 1916

  Fly  1946 RSGVKTGYQGLMIRRWQERGVKVVIDTSDVTTAAGAKKLLENSNKLALVGGIFNLAAVLRDALIE 2010
            ||||:.|||...|:.|:..|:||::...||.:.....:|:|.:.:|..||||||||.||:||:||
 Frog  1917 RSGVRNGYQAKQIQTWKGMGIKVLVSGKDVGSLEETLQLIEEAGQLGPVGGIFNLAMVLKDAMIE 1981

  Fly  2011 DQTAKDFKTVADPKVTATKYLDQFSRDICTELDYFICFSSVSCGRGNIGQTNYGLANSAMERICE 2075
            :.|.:.|:.|..||...|..||:.||:.|.|||:|:.||||||||||.||:|||.|||.||||||
 Frog  1982 NLTTQLFQDVNKPKYDGTLNLDRVSREKCPELDHFVAFSSVSCGRGNAGQSNYGFANSTMERICE 2046

  Fly  2076 QRQVSGFPGTAIQWGAIGDTGLVLENLGDNDTVIGGTLPQRMPSCLQTIDLFLQQPHPVVASMVV 2140
            :|:....||.|:|||||||.|:|||.:|.||||||||||||:.||::.:|.||.|||||::|.|:
 Frog  2047 KRRRDNLPGLAVQWGAIGDVGVVLETMGSNDTVIGGTLPQRIVSCMEVLDQFLNQPHPVMSSFVL 2111

  Fly  2141 AEKRKSDQSAGVS---LIATIANILGLRDTKNIQDGASLADLGMDSLMSAEIKQTLERNFDIVLS 2202
            |||..|.:|.|.|   |:..:|:|||:||..::....:|||||:||||..|::|||||::|||::
 Frog  2112 AEKTLSVKSKGSSQQDLVEAVAHILGVRDINSLNPDTTLADLGLDSLMGVEVRQTLERDYDIVMA 2176

  Fly  2203 AQEIRQLTFGALKAMDGGADVKPAAAAPAAAAGVPEANITSGGSSRTASPMGDGTQVVFTTSLIP 2267
            .:|:||||...|:.:.........|.:...::..||.:|.            |.|.::.......
 Frog  2177 MREVRQLTINKLRELSSKPSTMEDAKSTQKSSVPPELSIL------------DLTNLLVNPDAST 2229

  Fly  2268 TEAIVQLDTKAPANSKQSPIFFISPIEGFASALEPLAKRLEVPAYGLQYTEAVPSDSLESAAKFF 2332
            |..:..::|      .:.|:|.:.||||..:|...||.:|.:|.||||.|.|.|.||:.|.|.::
 Frog  2230 TTKLNNVET------DERPLFLVHPIEGSTAAFHSLASKLAIPCYGLQCTRAAPLDSIYSLASYY 2288

  Fly  2333 IKQLRTVQPKGPYKLAGYSFGCLLTYVMAGILEETNEVA----NVIMLDGAPSYVNWYTSSFKQR 2393
            .:.::.:||:|||.:||||||..:.:.|...|:...|.:    ::.:.||:.|||..||.|::.:
 Frog  2289 NQCIKQIQPEGPYLIAGYSFGACVAFEMCSQLQAQREASQAPDSLFLFDGSHSYVAAYTQSYRAK 2353

  Fly  2394 YTDGTNADNDNQSYGLAYFGIVLANIDYKALVRLLIVIPTWEEKLERFAELMS---NEITQPVET 2455
            .|.|:.|:.:.::  |..|......::|..||..|:.:...|.::.....|::   .:|:|  |.
 Frog  2354 LTPGSEAEAETEA--LCAFIQQFTGMEYNKLVEALLPLKDLESRVISAVNLITQSHKDISQ--EA 2414

  Fly  2456 IKKSATLFYKKLELADGYQPTLKLKTNVTLVKP---TDNSAKLDEDYRLKEVCTKPVEVHTVEGN 2517
            ::.:|:.|:.||:.||.|.|..|.:.||||::.   |:....|..||||.|||...|.||.:||:
 Frog  2415 LQFAASSFFYKLKAADQYIPKNKYQGNVTLLRAKTRTEYGEGLGIDYRLSEVCDGKVSVHVIEGD 2479

  Fly  2518 HRTFLIEDQSLKTIQSIL 2535
            ||||| |...:.:|..|:
 Frog  2480 HRTFL-EGTGVDSIIGII 2496

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FASN1NP_001137778.2 PksD 137..1142 CDD:225858 505/1026 (49%)
PKS 140..544 CDD:238429 232/403 (58%)
KAsynt_C_assoc 502..612 CDD:292814 50/115 (43%)
Acyl_transf_1 633..950 CDD:298668 166/316 (53%)
hot_dog 990..1234 CDD:294345 96/257 (37%)
NADB_Rossmann 1358..>1550 CDD:304358 59/241 (24%)
PKS_ER 1593..1883 CDD:214840 181/289 (63%)
enoyl_red 1595..1883 CDD:176179 180/287 (63%)
KR_1_FAS_SDR_x <1901..2141 CDD:187657 139/239 (58%)
PKS_PP 2154..>2206 CDD:214834 25/51 (49%)
Abhydrolase 2286..2535 CDD:304388 92/258 (36%)
fasnXP_031750124.1 PKS 2..404 CDD:238429 232/403 (58%)
KAsynt_C_assoc 362..471 CDD:406579 50/115 (43%)
Acyl_transf_1 492..808 CDD:395567 166/316 (53%)
hot_dog 871..1111 CDD:412416 98/249 (39%)
Methyltransf_12 1251..1350 CDD:400515 16/99 (16%)
NADB_Rossmann 1326..>1519 CDD:419666 51/200 (26%)
PKS_ER 1565..1855 CDD:214840 181/289 (63%)
KR_1_FAS_SDR_x <1853..2112 CDD:187657 150/263 (57%)
PKS_PP 2125..>2180 CDD:214834 25/54 (46%)
Thioesterase 2241..2500 CDD:395776 93/261 (36%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 348 1.000 Domainoid score I1030
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 2041 1.000 Inparanoid score I50
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D19161at2759
OrthoFinder 1 1.000 - - FOG0001625
OrthoInspector 1 1.000 - - otm47538
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X4095
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
66.060

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