DRSC/TRiP Functional Genomics Resources

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Protein Alignment FASN1 and fasn2

DIOPT Version :9

Sequence 1:NP_001137778.2 Gene:FASN1 / 33524 FlyBaseID:FBgn0283427 Length:2540 Species:Drosophila melanogaster
Sequence 2:NP_001041530.1 Gene:fasn2 / 100000781 ZFINID:ZDB-GENE-041210-242 Length:2105 Species:Danio rerio


Alignment Length:2314 Identity:545/2314 - (23%)
Similarity:927/2314 - (40%) Gaps:528/2314 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   141 EIAITGFSGRLPESSTIEEFKQNLFDG----VDMVND--------DPRRWERGLYGLPDRIGK-- 191
            ||||.|.....|....:|.|.:.|.:|    |.:.||        ||..         .:.||  
Zfish     6 EIAIVGVGCHFPGGEGLENFWRVLLEGKNCAVQIPNDRFNLSQWYDPEE---------SKAGKTY 61

  Fly   192 -----LKDSDLENFDQQFFGVHQKQAECMDPLLRMLLELTHEAIIDAGLNPSDLRGSRTGVYIGV 251
                 |.|. |..||.:|||:.:.::..|||..::||:.|:.|:.|||:......|:|||||:|:
Zfish    62 TAKAALIDG-LNAFDHKFFGITEAESLSMDPQHKLLLQCTYRALEDAGIPMEKASGTRTGVYLGL 125

  Fly   252 SNSETE--------QHWCSDADRVNGYGLTGCARAMFANRISFTFDFKGPSYSIDTACSSSLYAL 308
            .|.:.|        :|    .....|   ||.|.::.|||||:.|:|.|||.:||.||||||.||
Zfish   126 MNRDFELATVRNNPKH----ISHTTG---TGVAMSIAANRISYIFNFTGPSVAIDCACSSSLVAL 183

  Fly   309 EQAFSDMREGKVDNALVAGAGLILKPTMSLQFKRLNMLSPDGSCKAFDESGNGYVRSDGCVVLLL 373
            ..|...:::|..|.::..|...||:|.:.:...:..|:||||:.|.|....:||.|.:||.|:||
Zfish   184 HFACQAIKQGDCDMSVCGGVSCILEPALFVALSKAKMISPDGTSKPFSSKADGYGRGEGCGVVLL 248

  Fly   374 QRTSAA----RRVYASILNVRTNTDGFKEQGITYPIGKMQNRLIRETYE-EIGLNPADVVYVEAH 433
            :....|    ..::..|.....|.||.....||.|....|..|:|:.|. |..|  ..|.|:|||
Zfish   249 KPLKRALEDHDHIWGVIGKTAVNQDGHSVSPITKPSMVQQEELLRKIYSTEADL--CSVQYIEAH 311

  Fly   434 GTGTKVGDPQEVNSITDFFCKDRTT---PLLIGSVKSNMGHSEPASGVCSVAKILIAMEEGVIPG 495
            ||||.||||.|..|::....|:|:.   ||:|||||||:||:|.|:||..:.|:|:.|:...|..
Zfish   312 GTGTPVGDPVEAGSMSKVIAKERSQKSGPLIIGSVKSNIGHTESAAGVAGLIKVLLMMQHETIVP 376

  Fly   496 NLHYNKPNPDLYGLVDGRLKVVDRNLP-----W-----NGGIIGLNSFGFGGANAHVILK---SN 547
            :|.|:|.|..:      .||.::.|:|     |     .|.|.|:|:|||||.|||.|:|   .:
Zfish   377 SLFYSKENSSI------DLKSLNMNIPTRVQKWISNNRAGRIAGINNFGFGGTNAHAIVKQYVQS 435

  Fly   548 PKPKALTPKDGALKVVLASGRTFEAVEQLLESASTNADDDEYLQLINEIHSKAIP----NHFFRG 608
            .|||: .|...:.:..:.|..:.:::..::...:......:...|.:.:::.|..    .|.:|.
Zfish   436 KKPKS-QPISKSCQYFVVSAASEKSMRNIIRDTADQIGAGKISDLQSLLYTSACRRSHLKHKYRN 499

  Fly   609 YGVVSSKGTHQ--------REVIESNDDKRPIWYIYSGMGSQWASMAKDLMKIE-AFAKTIQRCA 664
            ....||....|        :.::.|..|.|.: :::.|.|..:..|.:.|:|.| .|.:.|.:..
Zfish   500 AFQTSSLADLQDKLTAAVDKRLVLSKTDSRVV-FVFCGNGVTYQGMCQQLLKHETVFREEIVKIE 563

  Fly   665 DVLK-PEGVDLIDVL----TRSTDKSFENILNSFISIAAMQVALTDLLSSLGIHPDGIVGHSVGE 724
            .:|| ....:||::|    ..|.|.|...::...  :.|:|||:..||...||.||.::|||:||
Zfish   564 TLLKIYRRQNLIEMLEGRSEMSKDLSDPQLVQPL--LFAIQVAVFKLLKHWGISPDAVLGHSIGE 626

  Fly   725 LGCAYADGCFTPEQTVLAAYWRGKSILDTQLAKGKMAAV-GLSWEDAHSRVPSDCFPVC---HNS 785
            :..|:..|..:.|..|...::|  |.|.:.:..|||..| .::..:..:.:||....||   :||
Zfish   627 VAAAHCSGLLSLEDAVKVIHYR--SSLQSTVTGGKMLVVSNMAVSEILNMLPSHSGRVCLAAYNS 689

  Fly   786 EDNCTISGPEASIEALVAKL----NAEGVFAKAVNSSGYAFHSKYIAEAGPKLRKSLEKIIPNAK 846
            ..:||:||..|.|::|..||    |.:.:|.:.::... |:||           ..::.|:...|
Zfish   690 PQSCTLSGDAAEIDSLHQKLSSSTNGKDLFLRILDVPA-AYHS-----------HMMDPIVSRVK 742

  Fly   847 NRTARWISTSIPESAWNTPVAKQS------SAAYHVNNLLSPVLFHEALQHVPK---NAISVEIA 902
            .......:..:....::|.....|      :..|...|:...|.|.:|::...|   |.|.|||.
Zfish   743 EDIGSLQTCDLEMELFSTVTGVSSCSTDFITGEYWARNIRQAVEFEQAVKSATKNKRNVIFVEIG 807

  Fly   903 PHGLLQAILKRALGPDATNLSLVK--RGHENNVEFFLTNVGKLFAAGAQPQVLTLVRPISYPVGR 965
            |...||..:...||.|...:..|:  :.||.    .|..|.|||..||     .:...:.|....
Zfish   808 PRRSLQRYITETLGKDIAVVPAVQPDKDHET----MLAVVSKLFELGA-----NINWDLFYKGWE 863

  Fly   966 GTPMLNSKVGWDHTQKWLVAK------------FGKETSSGETIVEVDLSKEDDAFLAGHTIDGR 1018
            ..|:...:..:|..::.:.|.            ...:.|:..::...|||.|..|||..|..:|.
Zfish   864 AEPIPFPRYQFDDVKREVFASDLQLTGTTRNHPVVTQMSTDSSVFSCDLSSESVAFLQDHKHNGV 928

  Fly  1019 ILFPATGYMTLAWQTFAKMQGSEFHKTPVVMENL----VFHRATILNKNAV-VKFGI-NFFDGTG 1077
            .:.|...|..|...||     .|:.|..|.:.:|    .|.......:||. :|..: |..|...
Zfish   929 AIIPGAFYTELGLATF-----MEYAKPKVPLSSLQLSITFQSPLTFTQNAPHIKVQLENLADSMH 988

  Fly  1078 AFEICESGSLAVSGKITI-PESIDNEELPLEEQTPSAVAKELGTNDVYKELRLRGYDYGGIFRGI 1141
            .|:|..:.::...|.:.: |.....|:....:.........:.:.:.||:|...|:.||.:||. 
Zfish   989 NFKIHSTSAVYAFGSVEVQPGRRPEEQFISLDSISRRCTLHMTSEEFYKQLSQTGFQYGSVFRN- 1052

  Fly  1142 VRSDTVASTGKLQWVDNWISFMDTMLQFSILSKNLRELY--------LPTRIERAVIN------- 1191
             ::|.....          .|.:.:....:..:.|.:|:        |...::.|.:.       
Zfish  1053 -KADVYCGE----------EFREALSVVKVPKELLHQLHDYHLHPVVLDYFMQLAPVTLGNDQSA 1106

  Fly  1192 ----PAKHFELLSALTKEEQVETGLPVQWYSDINVIKSAGVELRGLKANLAQRRPGTQAPPTLER 1252
                ||:    :::||..|.::..|.|  |.....:...|.|:.|..||       .|....:| 
Zfish  1107 RPQFPAQ----IASLTVFEPLQEELVV--YLRAVDVGDDGFEICGCLAN-------KQGRVLVE- 1157

  Fly  1253 YQFVPNINTTDLNENSEKARLHALDVAIQVIIENSSGAVKLK--------GVELANGRNPDVLVA 1309
               :.::....:...||..:.:....:..:|.|:.....::|        |:..|..::.|  ..
Zfish  1158 ---IKHVKIKMIGSRSEVVKEYFFHNSFDIISEDDMLDTQIKALVFSDQLGIFKALQQHLD--SR 1217

  Fly  1310 NRLLQIIEGEPVLTGDVAVVTSNNNEETITAALGDSGVRVVSKDVLKEPVEQNCHFVFG-IDVLS 1373
            :|.:...:...:|.|.|         ||:.:.|..|.|:...:::|         |::. .|:.:
Zfish  1218 SRCVSFSDSSTLLEGGV---------ETLLSKLAISSVKKNFQEIL---------FMWSDADLTT 1264

  Fly  1374 RPDTKTLENS-------------IASIRENGFL----------ILEETLPTYTKTGRALLTKFGF 1415
            ....|.||:.             :.:::..|.:          |::...|.|..||   :|:...
Zfish  1265 LESEKVLESMAGCCEMFRKTVRYLKALQFPGVIRVITYRSSESIVDSINPGYVLTG---MTRACA 1326

  Fly  1416 VAVQEQSLGATRVLVLARKAVDLKTRKSVVVVATEQNFNWVDDLKAALATAATEEQYVYVVCQGE 1480
            ..:||          |:.:.:|:.:..|             :|:||                   
Zfish  1327 AELQE----------LSFQLIDMGSGTS-------------EDIKA------------------- 1349

  Fly  1481 ELFGAVGLMTCIKNENGGKLARLVFVQDAKAEKFSLTSTLYRQQLEKDLISNVLKNGAWGTFRHL 1545
                   |:..:::....|...||..:                       .|:|:    ....|.
Zfish  1350 -------LVQVLRSYPCHKYPELVVKE-----------------------GNILQ----PEITHT 1380

  Fly  1546 KLETQQATLQVEHAYVNALVKGDLASLKWIEA-AQADTAATVDKNLETCTVYYAPINFRDVMLTS 1609
            .|.:..:.||..|     ::..:|..|:..:. |..:.:||..:|      ...||..:.|.|..
Zfish  1381 PLPSMASPLQKVH-----MLDEELFILQTSDPYAMRNLSATEMEN------SIQPIQGKHVELHL 1434

  Fly  1610 GKL---AADALP---GDL------------AEQDCVLGLEFAGRDTQ----------GRRVMAMV 1646
            .|:   ::|..|   .||            ::...:|.|:::|..|.          |..|::..
Zfish  1435 NKICVHSSDYFPVSMSDLSYGHTLYWNKHTSQHHNLLALDYSGTVTAVGKDVSKFKVGDHVVSCY 1499

  Fly  1647 PAKSL------ATTCVASKRMMWQIPEKWTMEEASTVPCVYSTVYYALVVRGQMKKGEKILIHAG 1705
            |..:.      |..|..:||:.:          .:.:|||   .|..|...         ::|  
Zfish  1500 PVSATSKVVIPAAVCCKAKRLSF----------LNDIPCV---SYMVLAWE---------ILH-- 1540

  Fly  1706 SGGVGQAAISVALAHGLTVFTTVGSKEKREFLLKRFPKLQERNIGNSR-DTSFEQLVLRETKGRG 1769
                 :|...:.:...|.:|:||........||    .:..|:..|.: .|..:||....::..|
Zfish  1541 -----KALPKIKVQRKLGIFSTVPDSALINVLL----AIANRSGWNVKVCTQTDQLSCDFSEVVG 1596

  Fly  1770 VDLVLNSLSEEKLQASIRCLGLNGRFLEIGKFDLSNNSPLGMSVFLKNTS----FHGILLDSVME 1830
            . :.|...:....:.:.|..|:|.   .:...|.....||..:.| ::|:    ||.:.:..|::
Zfish  1597 A-VFLPPYNLVTAEVASRIKGIND---IVFVCDNQTEVPLNSATF-RSTNEEVHFHFVFMSQVLQ 1656

  Fly  1831 GEEEMQNQVVSLV-----------AEGIKTGAVVPLPTSVFNDQQVEQAFRFMASGKHIGKVVIK 1884
             :..:|.|:..:.           :..:.|.||.                  .|:.:||..:.:|
Zfish  1657 -KWSLQTQMPKIYRWQKSMHLNRKSMSLDTTAVQ------------------RANSQHIDLLSVK 1702

  Fly  1885 VRDEEAGKKAL-------QPKPRL--INAIPRTYMHPEKS-YILVGGLGGFGLELTNWLVTRGAR 1939
            ..|.....:.|       :.|.:|  |..||:..:..:|| ||:.|||.|.|.|...::..:|..
Zfish  1703 ESDSYFTCQILPIIILNSEDKNQLSEIPVIPKNNLFKKKSVYIVTGGLTGLGFETVKFIAQKGGE 1767

  Fly  1940 YIVLTSRSGVKTGYQGLMIRRWQERGVKVVIDTSDVT-------TAAGAKKLLENSNKLALVGGI 1997
            :||:.||.......|..:.:.....|..:.....||:       |.|..|||..:|.    :.|:
Zfish  1768 HIVILSRRNPNPEMQQEISQLSSRCGSVIKSLPCDVSVSEQVDQTIAKVKKLFPSSP----IKGV 1828

  Fly  1998 FNLAAVLRDALIEDQTAKDFKTVADPKVTATKYLDQFSRDICTELDYFICFSSVSCGRGNIGQTN 2062
            |:.|.||.|.|||......::.|..|||.....|.:.:  |...||||:|:||:|...||..|||
Zfish  1829 FHSAVVLHDGLIERLDKSLYEKVMRPKVNGVINLHRAT--IQCNLDYFVCYSSISAFMGNASQTN 1891

  Fly  2063 YGLANSAMERICEQRQVSGFPGTAIQWGAIGDTGLVLENLG-DNDTVIGGTLPQRMPSCLQTID- 2125
            |..||:.|:..|:.|:..|..|.:|.|||: :.||:|:.:. .......|.|...:|...:::: 
Zfish  1892 YAAANTFMDTFCQYRRNIGLAGQSINWGAL-NLGLLLDKVHFQRFLEAKGILLLEVPEIHESLEQ 1955

  Fly  2126 -LFLQQPHPVVA--------SMVVAEKRKSDQ-----------SAGVS----------------- 2153
             |.:.:|..||.        :.|:::.:..:.           .|||:                 
Zfish  1956 CLLINKPQQVVCRFSFKNSWNSVLSQNKSLNARLFKIAKEAFIRAGVNPSRPEQPMTSSSPHDYL 2020

  Fly  2154 --LIATIANILGLRDTKNIQDGASLADLGMDSLMSAEIK 2190
              ||:..|.:    :...:.|...|.:||:||:::..::
Zfish  2021 RFLISETAGV----EKDELSDDVHLFELGIDSMLAMTLQ 2055

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FASN1NP_001137778.2 PksD 137..1142 CDD:225858 314/1104 (28%)
PKS 140..544 CDD:238429 162/447 (36%)
KAsynt_C_assoc 502..612 CDD:292814 29/126 (23%)
Acyl_transf_1 633..950 CDD:298668 93/341 (27%)
hot_dog 990..1234 CDD:294345 55/269 (20%)
NADB_Rossmann 1358..>1550 CDD:304358 28/215 (13%)
PKS_ER 1593..1883 CDD:214840 59/339 (17%)
enoyl_red 1595..1883 CDD:176179 59/337 (18%)
KR_1_FAS_SDR_x <1901..2141 CDD:187657 80/260 (31%)
PKS_PP 2154..>2206 CDD:214834 9/37 (24%)
Abhydrolase 2286..2535 CDD:304388
fasn2NP_001041530.1 PksD 3..971 CDD:225858 296/1021 (29%)
PKS 5..429 CDD:238429 162/447 (36%)
PKS_AT 533..833 CDD:214838 84/315 (27%)
hot_dog 895..1169 CDD:294345 59/307 (19%)
MDR 1471..>1522 CDD:302572 11/50 (22%)
KR_FAS_SDR_x 1593..1969 CDD:187582 104/406 (26%)
PP-binding 2018..2085 CDD:278949 9/42 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D19161at2759
OrthoFinder 1 1.000 - - FOG0001625
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100178
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
43.820

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