DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17221 and rtn4ip1

DIOPT Version :9

Sequence 1:	NP_001259984.1	Gene:	CG17221 / 33521	FlyBaseID:	FBgn0031500	Length:	413	Species:	Drosophila melanogaster
Sequence 2:	NP_956646.1	Gene:	rtn4ip1 / 393323	ZFINID:	ZDB-GENE-040426-1314	Length:	359	Species:	Danio rerio

Alignment Length:	367	Identity:	134/367 - (36%)
Similarity:	209/367 - (56%)	Gaps:	19/367 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 MRGWQLHNYGDIDELQLSEMLKIPQIRCSNECLVRIRATAVNPIDLAMLRGYGATVLNKMRCQP- 115
            |..|.:..||..|.|:.::...:|.|...||.:|::.|..:||||::|..||||..: .|:..|
Zfish     1 MPAWVIDKYGKNDVLRFTKNAALPIIHYPNEVVVKVHAAGLNPIDISMRGGYGAATM-AMKRDPL 64

  Fly   116 ---GDGIEFPLILGREFCGELVQTGMGVS-LPLGSRVWGVVPLQATIGSHAEYVAVPSYCLAPAP 176
               ..|.||||||||:..||:::.|:.|. ...|.:||..:|.... ||.||:|.|....::..|
Zfish    65 NISQSGGEFPLILGRDVSGEIMECGLDVKYFKPGDQVWAAIPPWKQ-GSLAEFVVVSGNEVSHKP 128

  Fly   177 KELDDYEAASVLYAGLTAWSGLYITGGLGGPCGATTASGGGAHKRVLVLGGSGGVGTLAIQILKS 241
            |.|...||||:.|...||||.:..||||.        ....|.||||:|||||||||.|||::|:
Zfish   129 KSLRHDEAASIPYVAATAWSAIVNTGGLN--------KDNSAKKRVLILGGSGGVGTFAIQMVKA 185

  Fly   242 QKVQVLATCSENAIEMVRNLGADLVVDYNNPQAMEELCKYAPYDIVLDCAGQGGQKAA---ESKY 303
            ....|..|||:||..:||:||||.||||......::|.....:|::||..|...:|.|   ...:
Zfish   186 WGAHVTVTCSQNAERLVRDLGADDVVDYTAGPVEKQLKNLEKFDLILDSIGGETEKWALDLLKPW 250

  Fly   304 DFRQYITFSSPLLANIDKQGLGVGALKNVFDLFQTNVRSVTQRGGLVKWGFFSPAPQGIQFLQKL 368
            ...:::|..:|.|.|.|:.||..|.:::...:....|::: ::|...:||||:|:...:..:.::
Zfish   251 SGAKFVTLITPFLQNTDRLGLADGMMQSAVTVGCKVVKNL-RKGVHYRWGFFAPSGSALDEVSEM 314

  Fly   369 VEQRKLMPLIDSSYGFSELPKAFEKMKSGHLRGKIVVKLREE 410
            |:..|:.|:::..:.|:::|:||:|::.||.|||.||.:.|:
Zfish   315 VDAGKVRPVVEEVFSFAQVPEAFQKVEQGHARGKTVVSIMED 356

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17221	NP_001259984.1	RTN4I1	52..406	CDD:176210	132/361 (37%)
CG17221	NP_001259984.1	Qor	52..406	CDD:223677	132/361 (37%)
rtn4ip1	NP_956646.1	Qor	1..353	CDD:223677	133/362 (37%)
rtn4ip1	NP_956646.1	RTN4I1	1..352	CDD:176210	132/361 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594227
Domainoid	1	1.000	86	1.000	Domainoid score	I8098
eggNOG	1	0.900	-	-		E1_COG0604
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H13105
Inparanoid	1	1.050	230	1.000	Inparanoid score	I3430
OMA	1	1.010	-	-		QHG53549
OrthoDB	1	1.010	-	-		D558414at33208
OrthoFinder	1	1.000	-	-		FOG0001925
OrthoInspector	1	1.000	-	-		oto39030
orthoMCL	1	0.900	-	-		OOG6_100491
Panther	1	1.100	-	-	LDO	PTHR11695
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3553
SonicParanoid	1	1.000	-	-		X3759
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800