Protein Alignment HTR1D and Oamb

DIOPT Version :10

• Sequence 1: NP_000855.1
• Gene: HTR1D / 3352
• HGNCID: 5289
• Length: 377
• Species: Homo sapiens
• Sequence 2: NP_001262774.1
• Gene: Oamb / 43982
• FlyBaseID: FBgn0024944
• Length: 751
• Species: Drosophila melanogaster
• Alignment Length: 594
• Identity: 145/594 - (24%)
• Similarity: 205/594 - (34%)
• Gaps: 249/594 - (41%)

Human    20 LNATE-----TSEAW-DPRTLQALKISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIG 78
            :|.||     .|..| :|..|    |||| ||..|.:..:..|..|:..:..:.||.:..|:.|.
  Fly     1 MNETECEDLIKSVKWTEPANL----ISLA-VLEFINVLVIGGNCLVIAAVFCSNKLRSVTNFFIV 60

Human    79 SLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDA 143
            :||..||||.:.|:|.|..:.:...|.||.:.|.|||:.|:..||||||:||.|:||||.|:|..
  Fly    61 NLAVADLLVGLAVLPFSATWEVFKVWIFGDLWCRIWLAVDVWMCTASILNLCAISLDRYVAVTRP 125

Human   144 LEYSKRRTAGHAATMIAIVWAISICISIPPLF-WRQAKA-------------------------- 181
            :.|....:...|.::||.:|.:|..|..|||. |:..||
  Fly   126 VTYPSIMSTKKAKSLIAGIWVLSFFICFPPLVGWKDQKAVIQPTYPKGNHTLYYTTTMSSSEDGQ 190

Human   182 ----------------------------------------------------------------- 181
                                                                             
  Fly   191 LGLDSIKDQGEASLPPSPPHIGNGNAYNPYDPGFAPIDGSAEIRIAAIDSTSTSTTATTTTTASS 255

Human   182 ----QEEMSDCLVN--------------------TSQISYTIYSTCGAFYIPSVLLIILYGRIYR 222
                :.||...|:|                    |:...|.:||..|:||||..:::..|.||||
  Fly   256 SSTTETEMDLDLLNAPPQNRPQTISGSCPWKCELTNDRGYVLYSALGSFYIPMFVMLFFYWRIYR 320

Human   223 AA--RNRILNP-------PSLYGKRFTTAHLI-----------------TGSAGSSLCSLNS--- 258
            ||  ..|.:|.       ....|.||....|.                 .||..|:..:|.:
  Fly   321 AAVRTTRAINQGFKTTKGSKGIGSRFEEQRLTLRIHRGRGSNQQDSMHSNGSTQSTTTTLGTPSP 385

Human   259 ---------SLHE-------------------------GHS-HSAGSPLFFNHVK---------- 278
                     .||.                         ||. ..:|:.||..|..
  Fly   386 ERLSKYATRRLHHHDKIKISVSYPSSENISELAGHGDVGHERRQSGNALFAVHYNGTNGRESTES 450

Human   279 -----------------------------------------IKLADSALERKRISA-----ARER 297
                                                     .:.|:..:.|:.|.|     ..|.
  Fly   451 QLYRQQQQHGVASSCYLQVGKGLPELARRQSNTSEAGGSGHSRPANKKMGRRNIKAQVKRFRMET 515

Human   298 KATKILGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEE 362
            ||.|.|.||:|.||.||.|||.:.::.|.|:| | :.|.||....||||.||.:||:||.:|:::
  Fly   516 KAAKTLAIIVGMFIFCWCPFFTMYIIRPFCQD-C-VDPLLFSVLFWLGYCNSAVNPMIYALFSKD 578

Human   363 FRQAFQKIV 371
            ||.||::|:
  Fly   579 FRFAFKRII 587

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HTR1D	NP_000855.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23		1/2 (50%)
		7tmA_5-HT1B_1D	35..367	CDD:320455	135/567 (24%)
		TM helix 1	40..66	CDD:320455	8/25 (32%)
		TM helix 2	73..99	CDD:320455	11/25 (44%)
		TM helix 3	111..141	CDD:320455	19/29 (66%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595	135..137		1/1 (100%)
		TM helix 4	153..176	CDD:320455	9/23 (39%)
		TM helix 5	194..223	CDD:320455	12/28 (43%)
		TM helix 6	294..324	CDD:320455	15/29 (52%)
		TM helix 7	335..360	CDD:320455	13/24 (54%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	352..356		2/3 (67%)
Oamb	NP_001262774.1	7tmA_Octopamine_R	21..583	CDD:320191	136/568 (24%)
		TM helix 1	22..48	CDD:320191	9/26 (35%)
		TM helix 2	55..81	CDD:320191	11/25 (44%)
		TM helix 3	93..123	CDD:320191	19/29 (66%)
		TM helix 4	135..158	CDD:320191	9/22 (41%)
		TM helix 5	292..321	CDD:320191	12/28 (43%)
		TM helix 6	512..542	CDD:320191	15/29 (52%)
		TM helix 7	551..576	CDD:320191	13/24 (54%)