| Sequence 1: | NP_000855.1 | Gene: | HTR1D / 3352 | HGNCID: | 5289 | Length: | 377 | Species: | Homo sapiens |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_001263131.1 | Gene: | 5-HT7 / 43669 | FlyBaseID: | FBgn0004573 | Length: | 564 | Species: | Drosophila melanogaster |
| Alignment Length: | 382 | Identity: | 144/382 - (37%) |
|---|---|---|---|
| Similarity: | 210/382 - (54%) | Gaps: | 59/382 - (15%) |
- Green bases have known domain annotations that are detailed below.
|
Human 39 ISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTITHT 103
Human 104 WNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAATMIAIVWAISIC 168
Human 169 ISIPPLFWRQAKAQEEMSDCLVNTSQ-ISYTIYSTCGAFYIPSVLLIILYGRIYRAARNRILN-- 230
Human 231 ---------------------PP--------SLYGKRFTTA--HLITGSAGSSLCSLNSSLHEGH 264
Human 265 SHSA---------GSPLFFNHVKIKLADSALERKRISAARERKATKILGIILGAFIICWLPFFVV 320
Human 321 SLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKIVPFRKAS 377 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| HTR1D | NP_000855.1 | Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1..23 | ||
| 7tmA_5-HT1B_1D | 35..367 | CDD:320455 | 138/370 (37%) | ||
| TM helix 1 | 40..66 | CDD:320455 | 7/25 (28%) | ||
| TM helix 2 | 73..99 | CDD:320455 | 13/25 (52%) | ||
| TM helix 3 | 111..141 | CDD:320455 | 20/29 (69%) | ||
| Agonist binding. /evidence=ECO:0000250 | 114..123 | 4/8 (50%) | |||
| DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250 | 135..137 | 1/1 (100%) | |||
| TM helix 4 | 153..176 | CDD:320455 | 9/22 (41%) | ||
| TM helix 5 | 194..223 | CDD:320455 | 12/29 (41%) | ||
| TM helix 6 | 294..324 | CDD:320455 | 17/29 (59%) | ||
| Agonist binding. /evidence=ECO:0000250 | 314..318 | 3/3 (100%) | |||
| TM helix 7 | 335..360 | CDD:320455 | 14/24 (58%) | ||
| NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250 | 352..356 | 3/3 (100%) | |||
| 5-HT7 | NP_001263131.1 | 7tm_4 | 173..>342 | CDD:304433 | 75/168 (45%) |
| 7tm_1 | 179..507 | CDD:278431 | 127/343 (37%) | ||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 0 | 0.000 | Not matched by this tool. | |||
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 1 | 0.950 | - | 0 | Normalized mean entropy | S4745 |
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 1 | 1.000 | - | - | otm40316 | |
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 1 | 1.030 | - | avgDist | Average_Evolutionary_Distance | R3253 |
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 4 | 3.890 | |||||