Protein Alignment HTR1D and AdoR

DIOPT Version :10

• Sequence 1: NP_000855.1
• Gene: HTR1D / 3352
• HGNCID: 5289
• Length: 377
• Species: Homo sapiens
• Sequence 2: NP_651772.1
• Gene: AdoR / 43583
• FlyBaseID: FBgn0039747
• Length: 774
• Species: Drosophila melanogaster
• Alignment Length: 374
• Identity: 103/374 - (27%)
• Similarity: 168/374 - (44%)
• Gaps: 46/374 - (12%)

Human     7 SAEG--LPQEASNRSLNATETSEAWDPRTLQALKISLAVVLSVITLATVLSNAFVLTTILLTRKL 69
            |.||  ||..|:..|.:|.::.   .|.:  .|.|...|...::.:.:::.|..|:......|||
  Fly    13 SFEGPLLPLHAATTSKDAKDSD---SPSS--ELNIPYTVFEVLVAIVSIIGNVLVIIVFRRERKL 72

Human    70 HTPANYLIGSLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDITCCTASILHLCVIAL 134
            ....||.|.|||..||||..|.:|.:|..::....|..  .|...:|..:..||.||..|..:::
  Fly    73 RRRTNYYIVSLAMADLLVGALGIPFAILASMGLPRNLH--ACLFTVSLLVVLCTISIFCLVAVSV 135

Human   135 DRYWAITDALEYSKRRTAGHAATMIAIVWAISICISIPPLFWRQAKAQEEMSDCLVNTSQISYTI 199
            ||||||...:.||:......|..:|::.|.....:...|||...|..........|.....:|.:
  Fly   136 DRYWAILYPMAYSRNVRTRTAIFIISMCWVAGTIVGFLPLFGWHADVNHNQECLFVEVMDYNYLV 200

Human   200 YSTCGAFYIPSVLLIILYGRIYRAARNRI-----LNPPSLYGKRFTTAHLITGSAGSSLCSLNSS 259
            :........|::|::..|..|||....::     :||.|...:|.:.|.:...:.|..
  Fly   201 FLYFATIITPALLMLAFYTHIYRVIIKQVRQIVTMNPASDLSRRSSAAVVQVTTPGRG------- 258

Human   260 LHEGHSHSAGSPLFFNHVKIKLADSALERKRISAARER--KATKILGIILGAFIICWLPFFVVSL 322
               ||:   |:.|                :.:.|||:|  |||:.|.||:..|:|||:|.:.::.
  Fly   259 ---GHT---GTML----------------RVLGAARKRDVKATQNLSIIVLFFMICWIPLYTINC 301

Human   323 VLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKIV 371
            :...|.| |::||.|..|...|.:|||.:||::|....::||.|.:.::
  Fly   302 IKAFCPD-CYVHPKLTLFCIILSHLNSAVNPVLYAYHLKDFRAALKNLL 349

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HTR1D	NP_000855.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23		7/17 (41%)
		7tmA_5-HT1B_1D	35..367	CDD:320455	93/338 (28%)
		TM helix 1	40..66	CDD:320455	3/25 (12%)
		TM helix 2	73..99	CDD:320455	13/25 (52%)
		TM helix 3	111..141	CDD:320455	12/29 (41%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595	135..137		1/1 (100%)
		TM helix 4	153..176	CDD:320455	5/22 (23%)
		TM helix 5	194..223	CDD:320455	6/28 (21%)
		TM helix 6	294..324	CDD:320455	14/31 (45%)
		TM helix 7	335..360	CDD:320455	10/24 (42%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	352..356		2/3 (67%)
AdoR	NP_651772.1	7tmA_Adenosine_R	42..345	CDD:341316	92/334 (28%)
		TM helix 1	43..69	CDD:341316	3/25 (12%)
		TM helix 2	76..103	CDD:341316	13/26 (50%)
		TM helix 3	112..142	CDD:341316	12/29 (41%)
		TM helix 4	156..174	CDD:341316	3/17 (18%)
		TM helix 5	196..225	CDD:341316	7/28 (25%)
		TM helix 6	273..303	CDD:341316	12/29 (41%)
		TM helix 7	313..338	CDD:341316	10/24 (42%)