Protein Alignment HTR1D and Dop1R2

DIOPT Version :10

• Sequence 1: NP_000855.1
• Gene: HTR1D / 3352
• HGNCID: 5289
• Length: 377
• Species: Homo sapiens
• Sequence 2: NP_001263072.1
• Gene: Dop1R2 / 43484
• FlyBaseID: FBgn0266137
• Length: 807
• Species: Drosophila melanogaster
• Alignment Length: 442
• Identity: 156/442 - (35%)
• Similarity: 216/442 - (48%)
• Gaps: 90/442 - (20%)

Human    10 GLPQEASNRSLNAT--ETSEAWDP------------------RTLQAL---KISLAVVLSVITLA 51
            ||| .::...||||  .||....|                  ..|:||   ::.|...|.:.:.|
  Fly    58 GLP-TSTELVLNATTSATSATLSPAMVATGGGGTTTPEPDLSEFLEALPNDRVGLLAFLFLFSFA 121

Human    52 TVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAY-TITHTWNFGQILCDIWL 115
            ||..|:.|:..::..|.|||..||.|.|||..|.||.::|||.|..| .:.:||.||...||||.
  Fly   122 TVFGNSLVILAVIRERYLHTATNYFITSLAVADCLVGLVVMPFSALYEVLENTWFFGTDWCDIWR 186

Human   116 SSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAATMIAIVWAISICISIPPLFWRQAK 180
            |.|:...|||||:||||:|||||||||...|..|.|...||.:||.||..|..||.|.:.|.:|.
  Fly   187 SLDVLFSTASILNLCVISLDRYWAITDPFSYPMRMTVKRAAGLIAAVWICSSAISFPAIVWWRAA 251

Human   181 AQEEMS--DCLVNTSQISYTIYSTCGAFYIPSVLLIILYGRIYRAARNRILNPPSLYGKRFTTAH 243
            ...||.  .|.. |..:.|.::|:..:||:|.::::..|.||||||   ::...||   :..|..
  Fly   252 RDGEMPAYKCTF-TEHLGYLVFSSTISFYLPLLVMVFTYCRIYRAA---VIQTRSL---KIGTKQ 309

Human   244 LIT----------------------------------GSAGSSLCSLNS-SLHEGHSHSAGS--- 270
            ::.                                  |..|.||...:| |.|..|:|..|:
  Fly   310 VLMASGELQLTLRIHRGGTTRDQQNQVSGGGGGGGGGGGGGGSLSHSHSHSHHHHHNHGGGTTTS 374

Human   271 --------PLFFNHVKIKLA-------DSALERKRISAARERKATKILGIILGAFIICWLPFFVV 320
                    ||...| ...||       :.:|.||....|:|:||.|.|||::|.|||||||||||
  Fly   375 TPEEPDDEPLSALH-NNGLARHRHMGKNFSLSRKLAKFAKEKKAAKTLGIVMGVFIICWLPFFVV 438

Human   321 SLVLPICRDSCWIHPALFD-FFTWLGYLNSLINPIIYTVFNEEFRQAFQKIV 371
            :|:...|.: |..|..:.. ..||||::||.:||:||..::.:||:||.:::
  Fly   439 NLLSGFCIE-CIEHEEIVSAIVTWLGWINSCMNPVIYACWSRDFRRAFVRLL 489

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HTR1D	NP_000855.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23		5/12 (42%)
		7tmA_5-HT1B_1D	35..367	CDD:320455	143/391 (37%)
		TM helix 1	40..66	CDD:320455	7/25 (28%)
		TM helix 2	73..99	CDD:320455	14/26 (54%)
		TM helix 3	111..141	CDD:320455	21/29 (72%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595	135..137		1/1 (100%)
		TM helix 4	153..176	CDD:320455	10/22 (45%)
		TM helix 5	194..223	CDD:320455	9/28 (32%)
		TM helix 6	294..324	CDD:320455	21/29 (72%)
		TM helix 7	335..360	CDD:320455	10/25 (40%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	352..356		2/3 (67%)
Dop1R2	NP_001263072.1	7tmA_Dop1R2-like	122..485	CDD:320195	138/371 (37%)
		TM helix 2	143..169	CDD:320195	13/25 (52%)
		TM helix 3	182..212	CDD:320195	21/29 (72%)
		TM helix 4	224..246	CDD:320195	10/21 (48%)
		TM helix 5	266..295	CDD:320195	9/28 (32%)
		TM helix 6	297..442	CDD:320195	42/148 (28%)
		TM helix 7	453..478	CDD:320195	10/24 (42%)