Protein Alignment HTR1D and Octbeta1R

DIOPT Version :10

• Sequence 1: NP_000855.1
• Gene: HTR1D / 3352
• HGNCID: 5289
• Length: 377
• Species: Homo sapiens
• Sequence 2: NP_651057.1
• Gene: Octbeta1R / 42652
• FlyBaseID: FBgn0038980
• Length: 508
• Species: Drosophila melanogaster
• Alignment Length: 373
• Identity: 120/373 - (32%)
• Similarity: 184/373 - (49%)
• Gaps: 53/373 - (14%)

Human     6 QSAEGLPQEASNRSLNATETSEAWDPRTLQALKISLAVVLSVITLATVLSNAFVLTTILLTRKLH 70
            |::||...:|              |..:..||......::..|.||.:|.|..|:.:::..|||.
  Fly    89 QASEGSTDDA--------------DGSSHLALVFVKCFIIGFIILAAILGNMLVIVSVMRHRKLR 139

Human    71 TPANYLIGSLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALD 135
            ...||.:.|||..|:||::..|..:.:..|:..|.||.::||:|.|.|:...||||:|||.|::|
  Fly   140 IITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFSTASIMHLCCISVD 204

Human   136 RYWAITDALEYSKRRTAGHAATMIAIVWAISICISIPPLF---------WRQAKAQEEMSDCLVN 191
            ||:||...|:|....|......|:.:||.....:|..|:.         ::..|:...:.:..||
  Fly   205 RYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICSGWYTTTENYKYLKSNPHICEFKVN 269

Human   192 TSQISYTIYSTCGAFYIPSVLLIILYGRIYRAARNRILNPPSLYGKRFTTAHLITGSAGSSLCSL 256
            .   :|.|.|:..:|:||.::::.:|.|||:.|..:              ..|:..|..::|
  Fly   270 K---AYAIVSSSMSFWIPGIVMLSMYYRIYQEADRQ--------------ERLVYRSKVAAL--- 314

Human   257 NSSLHEGHSHSAGSPLFFNHVKIKLADSALERKRISAARERKATKILGIILGAFIICWLPFFVVS 321
               |.|.|...:..|.  ....|::..|.:...|    |||||.:.||||:.||:|||||||:..
  Fly   315 ---LLEKHLQISQIPK--PRPSIQVEQSTISTMR----RERKAARTLGIIMSAFLICWLPFFLWY 370

Human   322 LVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQK 369
            :|..:| |||.....|.....|:||.||.:|||||..||.:||.||:|
  Fly   371 IVSSLC-DSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAFKK 417

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HTR1D	NP_000855.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23		4/16 (25%)
		7tmA_5-HT1B_1D	35..367	CDD:320455	112/340 (33%)
		TM helix 1	40..66	CDD:320455	6/25 (24%)
		TM helix 2	73..99	CDD:320455	9/25 (36%)
		TM helix 3	111..141	CDD:320455	17/29 (59%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595	135..137		1/1 (100%)
		TM helix 4	153..176	CDD:320455	5/31 (16%)
		TM helix 5	194..223	CDD:320455	10/28 (36%)
		TM helix 6	294..324	CDD:320455	18/29 (62%)
		TM helix 7	335..360	CDD:320455	11/24 (46%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	352..356		3/3 (100%)
Octbeta1R	NP_651057.1	7tmA_DmOct-betaAR-like	109..415	CDD:320194	110/335 (33%)
		TM helix 1	109..135	CDD:320194	6/25 (24%)
		TM helix 2	142..168	CDD:320194	9/25 (36%)
		TM helix 3	180..210	CDD:320194	17/29 (59%)
		TM helix 4	222..245	CDD:320194	5/22 (23%)
		TM helix 5	269..298	CDD:320194	11/31 (35%)
		TM helix 6	343..373	CDD:320194	19/33 (58%)
		TM helix 7	383..408	CDD:320194	11/24 (46%)