Protein Alignment HTR1D and TyrRII

DIOPT Version :10

• Sequence 1: NP_000855.1
• Gene: HTR1D / 3352
• HGNCID: 5289
• Length: 377
• Species: Homo sapiens
• Sequence 2: NP_650651.1
• Gene: TyrRII / 42135
• FlyBaseID: FBgn0038541
• Length: 586
• Species: Drosophila melanogaster
• Alignment Length: 523
• Identity: 154/523 - (29%)
• Similarity: 214/523 - (40%)
• Gaps: 177/523 - (33%)

Human    10 GLPQEASNRSLNATETSEAWDPRTLQALKISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPAN 74
            |:|      |:|:...|.|| |::|     ::||.| ||.|.||:.|..|:..:|.||:|.|..|
  Fly    59 GVP------SMNSYLVSMAW-PKSL-----AVAVFL-VIILVTVVGNTLVILAVLTTRRLRTVTN 110

Human    75 YLIGSLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWA 139
            ..:.:||.||.||...|||.|:...||.||.||.||||||:|.||..|:.|||.||.|:||||.|
  Fly   111 CFVMNLAITDWLVGTCVMPPSVVLYITGTWRFGWILCDIWISLDILLCSGSILSLCAISLDRYLA 175

Human   140 ITDALEYS-KRRTAGHAATMIAIVWAISICISIPP-LFWRQ-AKAQEEMSDCLVNTSQISYTIYS 201
            :|..|.|| |||:...|..||.:||..::.|:.|| |.|.: .:.|.|..||..|.:: .|.::|
  Fly   176 VTQPLTYSKKRRSKRLALLMILVVWITALSITCPPYLGWYEVGRHQAEFVDCRYNQNK-GYVVFS 239

Human   202 TCGAFYIPSVLLIILY---GRIYRAARNRILN--------------------------------- 230
            ..|:|:||..:::.:|   |.:..:.|.||:.
  Fly   240 AMGSFFIPLTVMLYVYVKIGYVLTSRRQRIVRDAYSERTADYDVDGDNFISESEHYHCTPTKWLP 304

Human   231 --------------PPSLYGKRFTTAH-------------LITGSAG------------------ 250
                          |||.........|             ..||:||
  Fly   305 NRKSRWRFNSLHDPPPSAATNAAAKGHQSSVKCSKCSKCSSATGTAGAGAGAGVVDKTLTFKHQP 369

Human   251 -----------SSL--CSLNSSLHEG---HS-----HSAGSPLFF------------------NH 276
                       |||  ||..|..:.|   ||     |..|:...|                  |.
  Fly   370 TFYELVEVSRLSSLIHCSAISCKYGGPCMHSTPSGMHYVGTEASFSDTCLGGNVSNNTTTTTTNT 434

Human   277 VKI----KLADSALERK----------------------------------RISAA-RERKATKI 302
            |.:    ||...|.:::                                  |:|.. |:.|..|.
  Fly   435 VALETNEKLEAEAKQKQQQQRSSFDHHHPHAHHHGSHGQQSHHNHHHRMPMRVSTTKRDSKTAKT 499

Human   303 LGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAF 367
            |.|::|..|.|||||||..|::|.......:...:|. |||:|::|..|||.||..:|.:||.||
  Fly   500 LTIVMGGLIACWLPFFVYYLLIPFLPRPAVLEDLMFG-FTWIGWVNCAINPFIYAFYNPDFRTAF 563

Human   368 QKI 370
            .::
  Fly   564 WRL 566

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HTR1D	NP_000855.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23		4/12 (33%)
		7tmA_5-HT1B_1D	35..367	CDD:320455	143/493 (29%)
		TM helix 1	40..66	CDD:320455	11/25 (44%)
		TM helix 2	73..99	CDD:320455	11/25 (44%)
		TM helix 3	111..141	CDD:320455	19/29 (66%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595	135..137		1/1 (100%)
		TM helix 4	153..176	CDD:320455	9/23 (39%)
		TM helix 5	194..223	CDD:320455	8/31 (26%)
		TM helix 6	294..324	CDD:320455	15/30 (50%)
		TM helix 7	335..360	CDD:320455	11/24 (46%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	352..356		2/3 (67%)
TyrRII	NP_650651.1	7tm_GPCRs	78..>270	CDD:475119	85/193 (44%)
		TM helix 1	78..101	CDD:410628	10/23 (43%)
		TM helix 2	110..132	CDD:410628	10/21 (48%)
		TM helix 3	148..170	CDD:410628	13/21 (62%)
		TM helix 4	194..210	CDD:410628	5/15 (33%)
		TM helix 5	233..256	CDD:410628	6/23 (26%)
		7tm_GPCRs	<491..563	CDD:475119	30/72 (42%)
		TM helix 6	497..519	CDD:320098	12/21 (57%)
		TM helix 7	531..556	CDD:320098	11/25 (44%)