Protein Alignment HTR1D and 5-HT2A

DIOPT Version :10

• Sequence 1: NP_000855.1
• Gene: HTR1D / 3352
• HGNCID: 5289
• Length: 377
• Species: Homo sapiens
• Sequence 2: NP_730859.1
• Gene: 5-HT2A / 40575
• FlyBaseID: FBgn0087012
• Length: 930
• Species: Drosophila melanogaster
• Alignment Length: 613
• Identity: 133/613 - (21%)
• Similarity: 206/613 - (33%)
• Gaps: 265/613 - (43%)

Human    19 SLNATETSEAWDPRTLQALKIS-------------LAVVLSVITLATVLSNAFVLTTILLTRKLH 70
            :||.|.|:...|..|..|:..|             |.||..:  .|..|.|..|...:.|.|||.
  Fly   255 ALNTTSTASTADMATEFAVTKSFLDYSPHGYDFLFLFVVFFI--FAGGLGNILVCLAVALDRKLQ 317

Human    71 TPANYLIGSLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALD 135
            ...||.:.|||..|||||:.|||:.........|..|...|:|:::.|:..|::||||:|.|:|.
  Fly   318 NVTNYFLFSLAIADLLVSLFVMPMGAIPAFLGYWPLGFTWCNIYVTCDVLACSSSILHMCFISLG 382

Human   136 RYWAITDALEYSKRRTAGHAATMIAIVWAISICI--SIPPL-FWRQAKAQEEMSDCLVNTSQISY 197
            ||..|.:.|....|.|.......|||||.:::.:  ||..| ...:.....|.:.|::|..  ::
  Fly   383 RYMGIRNPLGSRHRSTKRLTGIKIAIVWVMAMMVSSSITVLGLVNEKNIMPEPNICVINNR--AF 445

Human   198 TIYSTCGAFYIPSVLLIILYG----RIYRAARNRILNPPS-LY---GKRFT-------------- 240
            .::.:..|||||.::::..|.    .:.:.||....:|.| |:   |.|||
  Fly   446 FVFGSLVAFYIPMLMMVTTYALTIPLLRKKARFAAEHPESELFRRLGGRFTLRPQHSQQQLQMFS 510

Human   241 ------------------------------------------------TA-----------HLIT 246
                                                            ||           :::.
  Fly   511 SFSGSNNKFLSMGDGNRNFNTEGEMEEGGAPSRRSGVEPAERPLMQQRTASSRSMGTVSFRNVVN 575

Human   247 GSAGS-------------------------SLCSLNSSLHE------------------------ 262
            |::|:                         |..|..||.|.
  Fly   576 GTSGAAGSGRRTTGTAHSSFRFSGAGIFRHSSSSPASSCHSTSTSRSSSFWRKHGGYPNLMDRLA 640

Human   263 ---------------------------------------------------GHSHSAG------- 269
                                                               |:..|||
  Fly   641 IHLRLSLVPPSSHPNRRASVRVTISQPQLGYPTNVGGNGGRTVGATEVGAGGNGSSAGRTSNSSL 705

Human   270 ------------SPLF-------FNHVKIKLADSAL----------------------------- 286
                        .|:.       .||:..|:..:||
  Fly   706 GGTSLMKIATIQGPILNQSQAAGGNHMVQKVKPTALKPEEPQRNKVRPFKFAFNRVATPTLNLRF 770

Human   287 -----ERKRISA---ARERKATKILGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTW 343
                 :|..:||   |.|:||||:||::...|::||.|||:::::...|.: |.:...:.:...|
  Fly   771 LNNRSKRNSLSANAVATEQKATKVLGLVFFTFVLCWSPFFILNIIFAACPE-CQVPEHVVNTCLW 834

Human   344 LGYLNSLINPIIYTVFNEEFRQAFQKIV 371
            |||::|.|||||||:||..||.||.:::
  Fly   835 LGYVSSTINPIIYTIFNRTFRAAFIRLL 862

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HTR1D	NP_000855.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23		2/3 (67%)
		7tmA_5-HT1B_1D	35..367	CDD:320455	125/591 (21%)
		TM helix 1	40..66	CDD:320455	8/38 (21%)
		TM helix 2	73..99	CDD:320455	13/25 (52%)
		TM helix 3	111..141	CDD:320455	13/29 (45%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595	135..137		0/1 (0%)
		TM helix 4	153..176	CDD:320455	8/25 (32%)
		TM helix 5	194..223	CDD:320455	6/32 (19%)
		TM helix 6	294..324	CDD:320455	14/29 (48%)
		TM helix 7	335..360	CDD:320455	12/24 (50%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	352..356		3/3 (100%)
5-HT2A	NP_730859.1	7tm_GPCRs	298..>473	CDD:475119	57/176 (32%)
		TM helix 2	321..343	CDD:410628	13/21 (62%)
		TM helix 3	359..381	CDD:410628	9/21 (43%)
		TM helix 4	404..420	CDD:410628	5/15 (33%)
		TM helix 5	443..466	CDD:410628	5/24 (21%)
		7tm_GPCRs	<779..858	CDD:475119	34/79 (43%)
		TM helix 6	792..814	CDD:410628	10/21 (48%)
		TM helix 7	826..851	CDD:410628	12/24 (50%)