| Sequence 1: | NP_000855.1 | Gene: | HTR1D / 3352 | HGNCID: | 5289 | Length: | 377 | Species: | Homo sapiens |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_001261169.1 | Gene: | CG13579 / 37905 | FlyBaseID: | FBgn0035010 | Length: | 716 | Species: | Drosophila melanogaster |
| Alignment Length: | 395 | Identity: | 98/395 - (24%) |
|---|---|---|---|
| Similarity: | 164/395 - (41%) | Gaps: | 85/395 - (21%) |
- Green bases have known domain annotations that are detailed below.
|
Human 42 AVVLSVITLATVLSNAFVLTTILLTR---KLHTPANYLIGSLATTDLLVSILVMPISIAYTITHT 103
Human 104 WNFGQILCDI--WLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAATMIAIVWAIS 166
Human 167 ICI----SIPPLFWRQAKAQEEMSDCLVNTSQISYTIYSTCGAFYIPSVLLIILYGRIYRAARNR 227
Human 228 ILNPPSLYGKRFTTA--------HLITGSAGSSL-----------CSLNSSLHEGHSHS------ 267
Human 268 -----------------------------AGSPLFFNHVKIKLADSALERKRISAARERKATKIL 303
Human 304 GIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFF-TWLGYLNSLINPIIYTVFNEEFRQAF 367
Human 368 QKIVP 372 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| HTR1D | NP_000855.1 | Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1..23 | ||
| 7tmA_5-HT1B_1D | 35..367 | CDD:320455 | 97/388 (25%) | ||
| TM helix 1 | 40..66 | CDD:320455 | 8/23 (35%) | ||
| TM helix 2 | 73..99 | CDD:320455 | 9/25 (36%) | ||
| TM helix 3 | 111..141 | CDD:320455 | 11/31 (35%) | ||
| Agonist binding. /evidence=ECO:0000250 | 114..123 | 1/8 (13%) | |||
| DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250 | 135..137 | 1/1 (100%) | |||
| TM helix 4 | 153..176 | CDD:320455 | 4/26 (15%) | ||
| TM helix 5 | 194..223 | CDD:320455 | 9/28 (32%) | ||
| TM helix 6 | 294..324 | CDD:320455 | 7/29 (24%) | ||
| Agonist binding. /evidence=ECO:0000250 | 314..318 | 1/3 (33%) | |||
| TM helix 7 | 335..360 | CDD:320455 | 11/25 (44%) | ||
| NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250 | 352..356 | 2/3 (67%) | |||
| CG13579 | NP_001261169.1 | 7tm_4 | 51..>148 | CDD:304433 | 29/98 (30%) |
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 0 | 0.000 | Not matched by this tool. | |||
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 1 | 0.910 | |||||