Protein Alignment HTR1D and 5-HT1A

DIOPT Version :10

• Sequence 1: NP_000855.1
• Gene: HTR1D / 3352
• HGNCID: 5289
• Length: 377
• Species: Homo sapiens
• Sequence 2: NP_001356890.1
• Gene: 5-HT1A / 37196
• FlyBaseID: FBgn0004168
• Length: 846
• Species: Drosophila melanogaster
• Alignment Length: 633
• Identity: 160/633 - (25%)
• Similarity: 234/633 - (36%)
• Gaps: 282/633 - (44%)

Human    16 SNRS-----------LNATETSEAWDPRTLQALKISL-AVVLSVITLATVLSNAFVLTTILLTRK 68
            :|||           ||.|.:..|.|..| |.|:::: :|:|.::.|.|::.|.||:..|:|.|.
  Fly   193 ANRSGQLDLINGTGGLNVTTSKVAEDDFT-QLLRMAVTSVLLGLMILVTIIGNVFVIAAIILERN 256

Human    69 LHTPANYLIGSLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDITCCTASILHLCVIA 133
            |...||||:.|||..||.|:.||||:...|.|:..|..|..|||||.|.|:.|||||||||..||
  Fly   257 LQNVANYLVASLAVADLFVACLVMPLGAVYEISQGWILGPELCDIWTSCDVLCCTASILHLVAIA 321

Human   134 LDRYWAITDALEYSKRRTAGHAATMIAIVWAISICISIPPLF-WRQAKAQE--EMSDCLVNTSQI 195
            :|||||:|: ::|...||:.....||..||..::.:|:.|.| |:.....:  |...|:| :..:
  Fly   322 VDRYWAVTN-IDYIHSRTSNRVFMMIFCVWTAAVIVSLAPQFGWKDPDYLQRIEQQKCMV-SQDV 384

Human   196 SYTIYSTCGAFYIPSVLLIILYGRIYRAARNRI-------------LNPPS-------------L 234
            ||.:::||..||:|.::::.||.:||:.||.||             .|.|.             |
  Fly   385 SYQVFATCCTFYVPLLVILALYWKIYQTARKRIHRRRPRPVDAAVNNNQPDGGAATDTKLHRLRL 449

Human   235 YGKRFTTAHLITGSA-----------------GSSLCSLNS------------------------ 258
            ...||:||...||||                 |:|..::|:
  Fly   450 RLGRFSTAKSKTGSAVGVSGPASGGRALGLVDGNSTNTVNTVEDTEFSSSNVDSKSRAGVEAPST 514

Human   259 --------------SLHEGHSHSAGSPLF------------------------------------ 273
                          :..:|.|.:..|...
  Fly   515 SGNQIATVSHLVALAKQQGKSTAKSSAAVNGMAPSGRQEDDGQRPEHGEQEDREELEDQDEQVGP 579

Human   274 ----------------------FNHVKIKLADSALE----------------------------- 287
                                  .|.|:: |.|..|:
  Fly   580 QPTTATSAMTAAGTNESEDQCKANGVEV-LEDPQLQQQLEQVQQLQKSVKSGGGGGASTSNATTI 643

Human   288 ----------------------------------------------------------------- 287
                                                                             
  Fly   644 TSISALSPQTPTSQGVGIAAAAAGPMTAKTSTLTSCNQSHPLCGTANESPSTPEPRSRQPTTPQQ 708

Human   288 -----------------------------RKRISAARERKATKILGIILGAFIICWLPFFVVSLV 323
                                         ::.:.|.|||||.|.|.||.|||::|||||||::|.
  Fly   709 QPHQQAHQQQQQQQQLSSIANPMQKVNKRKETLEAKRERKAAKTLAIITGAFVVCWLPFFVMALT 773

Human   324 LPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKIV 371
            :|:|. :|.|..::...|.||||.||.:||:|||:|:.||||||::|:
  Fly   774 MPLCA-ACQISDSVASLFLWLGYFNSTLNPVIYTIFSPEFRQAFKRIL 820

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HTR1D	NP_000855.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23		5/17 (29%)
		7tmA_5-HT1B_1D	35..367	CDD:320455	148/597 (25%)
		TM helix 1	40..66	CDD:320455	8/26 (31%)
		TM helix 2	73..99	CDD:320455	14/25 (56%)
		TM helix 3	111..141	CDD:320455	22/29 (76%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595	135..137		1/1 (100%)
		TM helix 4	153..176	CDD:320455	7/23 (30%)
		TM helix 5	194..223	CDD:320455	11/28 (39%)
		TM helix 6	294..324	CDD:320455	20/29 (69%)
		TM helix 7	335..360	CDD:320455	12/24 (50%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	352..356		2/3 (67%)
5-HT1A	NP_001356890.1	7tmA_5-HT1A_invertebrates	227..>413	CDD:320454	78/187 (42%)
		TM helix 1	228..254	CDD:320454	8/25 (32%)
		TM helix 2	261..287	CDD:320454	14/25 (56%)
		TM helix 3	299..329	CDD:320454	22/29 (76%)
		TM helix 4	340..362	CDD:320454	6/21 (29%)
		TM helix 5	383..412	CDD:320454	11/28 (39%)
		7tm_GPCRs	<743..816	CDD:475119	42/73 (58%)
		TM helix 6	750..772	CDD:410628	14/21 (67%)
		TM helix 7	784..809	CDD:410628	12/24 (50%)