Protein Alignment HTR1D and 5-HT1B

DIOPT Version :10

• Sequence 1: NP_000855.1
• Gene: HTR1D / 3352
• HGNCID: 5289
• Length: 377
• Species: Homo sapiens
• Sequence 2: NP_001137708.2
• Gene: 5-HT1B / 37191
• FlyBaseID: FBgn0263116
• Length: 629
• Species: Drosophila melanogaster
• Alignment Length: 571
• Identity: 161/571 - (28%)
• Similarity: 238/571 - (41%)
• Gaps: 197/571 - (34%)

Human     1 MSPLNQSAEGLPQEASNRSLNATETSEAWD------PRT-----LQALKISLAVVLSVITLATVL 54
            ::.|..:...|.|...|||:|....|..:|      .|.     |....|::||||.::.|.|::
  Fly    42 LTQLVDTTSNLSQIVWNRSINGNGNSNTFDLVDDEQERAAVEFWLLVKMIAMAVVLGLMILVTII 106

Human    55 SNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDI 119
            .|.||:..|:|.|.|...||||:.|||..||.|:.||||:...|.|::.|..|..|||||.|.|:
  Fly   107 GNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISNGWILGPELCDIWTSCDV 171

Human   120 TCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAATMIAIVWAISICISIPPLF-WRQAKAQE 183
            .|||||||||..||.||||.:|: ::|:..||......||..||..::.:|:.|.| |:.....:
  Fly   172 LCCTASILHLVAIAADRYWTVTN-IDYNNLRTPRRVFLMIFCVWFAALIVSLAPQFGWKDPDYMK 235

Human   184 EMSD--CLVNTSQISYTIYSTCGAFYIPSVLLIILYGRIYRAARNRILNPPS------------- 233
            .:.:  |:| :..:.|.|::||..||:|.::::.||.:||..||.||.....
  Fly   236 RIEEQHCMV-SQDVGYQIFATCCTFYVPLLVILFLYWKIYIIARKRIQRRAQKSFNVTLTETDCD 299

Human   234 -----------------------------------------------LYGKRFTTAHLITGS--- 248
                                                           .:|:...||:::.||
  Fly   300 SAVRELKKERSKRRAERKRLEAGERTPVDGDGTGGQLQRRTRKRMRICFGRNTNTANVVAGSEGA 364

Human   249 ----------------------------------AGSSLCSLNS--------------SLHEGHS 265
                                              ||:.|.:::|              :|.:..:
  Fly   365 VARSMAAIAVDFASLAITREETEFSTSNYDNKSHAGTELTTVSSDADDYRTSNANEIITLSQQVA 429

Human   266 HSAGSPLFFNHVK--IKLADS-------------------------------------------- 284
            |:....|..:|:.  ..||.|
  Fly   430 HATQHHLIASHLNAITPLAQSIAMGGVGCLTTTTPSEKALSGAGTVAGAVAGGSGSGSGEEGAGT 494

Human   285 -----------------------ALERKRISAARERKATKILGIILGAFIICWLPFFVVSLVLPI 326
                                   |..|:.:.|.|||||.:.|.||.|||:||||||||::|.:.:
  Fly   495 EGKNAGVGLGGVLASIANPHQKLAKRRQLLEAKRERKAAQTLAIITGAFVICWLPFFVMALTMSL 559

Human   327 CRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKIVPFRKAS 377
            |:: |.||.|:...|.||||.||.:||:|||:||.|||:||::|:..|||:
  Fly   560 CKE-CEIHTAVASLFLWLGYFNSTLNPVIYTIFNPEFRRAFKRILFGRKAA 609

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HTR1D	NP_000855.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23		7/21 (33%)
		7tmA_5-HT1B_1D	35..367	CDD:320455	144/514 (28%)
		TM helix 1	40..66	CDD:320455	10/25 (40%)
		TM helix 2	73..99	CDD:320455	14/25 (56%)
		TM helix 3	111..141	CDD:320455	21/29 (72%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595	135..137		1/1 (100%)
		TM helix 4	153..176	CDD:320455	7/23 (30%)
		TM helix 5	194..223	CDD:320455	11/28 (39%)
		TM helix 6	294..324	CDD:320455	20/29 (69%)
		TM helix 7	335..360	CDD:320455	13/24 (54%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	352..356		2/3 (67%)
5-HT1B	NP_001137708.2	TM helix 1	92..118	CDD:320454	10/25 (40%)
		TM helix 2	125..151	CDD:320454	14/25 (56%)
		TM helix 3	163..193	CDD:320454	21/29 (72%)
		TM helix 4	204..226	CDD:320454	6/21 (29%)
		TM helix 5	247..276	CDD:320454	11/28 (39%)
		7tm_GPCRs	<525..599	CDD:475119	43/74 (58%)
		TM helix 6	533..555	CDD:410628	14/21 (67%)
		TM helix 7	567..592	CDD:410628	13/24 (54%)
		7tmA_5-HT1A_invertebrates	91..>287	CDD:320454	83/197 (42%)