DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SerRS and DIA4

DIOPT Version :9

Sequence 1:	NP_001259982.1	Gene:	SerRS / 33518	FlyBaseID:	FBgn0031497	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_011875.1	Gene:	DIA4 / 856402	SGDID:	S000001053	Length:	446	Species:	Saccharomyces cerevisiae

Alignment Length:	466	Identity:	130/466 - (27%)
Similarity:	227/466 - (48%)	Gaps:	69/466 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 QKKRFKDVALVETV------------IAKDTEWRQCRHRADNLNKVKNVCSKVIGEKMKKKEPVG 75
            :|.:|....::|.:            |..|:..|..:...:....:|.: .|||.:       :.
Yeast    17 KKPQFDVKKIIEMIPQYQTSIQNRELIEADSIIRSLQLLGERYQNIKEI-DKVIAD-------IQ 73

  Fly    76 AMSEDLPADVTKDLTEIVAETLQPLTVNQIKQLRVLIDDAMTENQKSLELAEQTRNTSLREVGNH 140
            ...:.:.|.:.||.|:|...:.      .:|.|:...:|   :|.||.||.::...| .:.:.|.
Yeast    74 IQRKSIEAQIKKDKTKITEYSA------ALKALKEQYND---QNSKSSELKKKILET-CKSLPNT 128

  Fly   141 LHESVPVSNDEDENRVE--RTFGDCEKRGKYSHVDLIVMIDGMNAEKGAVVSGGRGYFLTGAAVF 203
            |..:||:...:.|..:.  :|....|.:   :|||:::..:.::.:..:.|:|...|:|......
Yeast   129 LDPTVPLDAPQIEQWINPLKTHKTSEAQ---AHVDIMLKKNMLDLQTASNVTGMSWYYLLNDGAR 190

  Fly   204 LEQALIQHALHLLYARDYVPLYTPFFMRKEVMQEVA---QLSQFDEELYKVVGKGSEKAEEVGID 265
            |||||:.:||.......:.....|...:||::....   :....:.::|.:        ::..:.
Yeast   191 LEQALVAYALKKANENGFSSCVPPSITKKELIDACGFNPRDMNNERQIYAL--------QDTNLG 247

  Fly   266 EKYLIATSEQPIAAYHRDEWLPESS--LPIKYAGLSTCFRQEVGSHGRDTRGIFRVHQFEKVEQF 328
               |:||:|.|:|....::.|..:|  ...|..|:|.|:|.|.|:.|:||:|::|||:|.|||.|
Yeast   248 ---LVATAEIPLAGLGANKVLELNSGECSKKLVGVSRCYRAEAGARGKDTKGLYRVHEFTKVELF 309

  Fly   329 VLTSPHDNKSWEMMDEMIGNAEQF----CQSLGIPYRVVNIVSGALNHAASKKLDLEAWFGGSGA 389
            ..:.|  ..|.::::|:    :||    .:.||||.:|:|:.|..|.:.|.||.|:|||..|.|.
Yeast   310 CWSKP--ETSAKVLEEI----KQFQISVVEELGIPAKVLNMPSNDLGNPAFKKYDIEAWMPGRGK 368

  Fly   390 YRELVSCSNCLDYQARRLLVRF--GQTKKMNAAVDYVHMLNATMCAATRVICAILET-HQTETG- 450
            :.|:.|.|||.|:|:|||..::  ..|.|:    :|||.||.|..|..|||.|::|. :...||
Yeast   369 FGEISSASNCTDFQSRRLNTKYRDDNTGKL----EYVHTLNGTAMAIPRVIVALVENFYDPSTGK 429

  Fly   451 IKVPEPLKKYM 461
            |.|||.|:::|
Yeast   430 ISVPECLREFM 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SerRS	NP_001259982.1	PLN02678	3..476	CDD:215364	130/466 (28%)
		Seryl_tRNA_N	3..111	CDD:280549	17/99 (17%)
		SerRS_core	153..461	CDD:238393	101/322 (31%)
DIA4	NP_011875.1	serS	1..440	CDD:273066	129/464 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0172
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S479
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100275
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.660