DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SerRS and SES1

DIOPT Version :9

Sequence 1:	NP_001259982.1	Gene:	SerRS / 33518	FlyBaseID:	FBgn0031497	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_010306.1	Gene:	SES1 / 851587	SGDID:	S000002430	Length:	462	Species:	Saccharomyces cerevisiae

Alignment Length:	514	Identity:	224/514 - (43%)
Similarity:	301/514 - (58%)	Gaps:	70/514 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 VLDLDLFRSDKGGNPDLVRENQKKRFKDVALVETVIAKDTEWRQCRHRADNLNKVKNVCSKVIGE 66
            :||::.|..||||||:|:|::||.|...|.:|:.:|:...:|.:.|...|.|||..|...|.||.
Yeast     1 MLDINQFIEDKGGNPELIRQSQKARNASVEIVDEIISDYKDWVKTRFELDELNKKFNKLQKDIGL 65

  Fly    67 KMKKKEPVGAMSEDLPADVTKDLTEIVAETLQPLTVNQIKQLRVLIDDAMTENQKSLELAEQTRN 131
            |.|.||               |.:.::||                 .:.:|:.:|.|...||..:
Yeast    66 KFKNKE---------------DASGLLAE-----------------KEKLTQQKKELTEKEQQED 98

  Fly   132 TSLR----EVGNHLHESVPVSNDEDENRVERTF--GDCE----------KRGKYSHVDLIVMIDG 180
            ..|:    :|||.:|.||.|||||:.|.:.||:  .|.|          |....||.::::.:||
Yeast    99 KDLKKKVFQVGNIVHPSVVVSNDEENNELVRTWKPEDLEAVGPIASVTGKPASLSHHEILLRLDG 163

  Fly   181 MNAEKGAVVSGGRGYFLTGAAVFLEQALIQHALHLLYARDYVPLYTPFFMRKEVMQEVAQLSQFD 245
            .:.::|..:.|.||||.....|||.||||.:.|..|.|:.|:||..|..|.||:|.:.||||:||
Yeast   164 YDPDRGVKICGHRGYFFRNYGVFLNQALINYGLQFLAAKGYIPLQAPVMMNKELMSKTAQLSEFD 228

  Fly   246 EELYKVVGKGSEKAEEVGIDEKYLIATSEQPIAAYHRDEWL--PESSLPIKYAGLSTCFRQEVGS 308
            ||||||:.         |.|||||||||||||:|||..||.  |:..|||.|.|.|:|||:|.||
Yeast   229 EELYKVID---------GEDEKYLIATSEQPISAYHSGEWFEKPQEQLPIHYVGYSSCFRREAGS 284

  Fly   309 HGRDTRGIFRVHQFEKVEQFVLTSPHDNKSWEMMDEMIGNAEQFCQSLGIPYRVVNIVSGALNHA 373
            ||:|..|:||||.|||:||||:|.|  .||||..::||..:|:|.:||.:|||:|.||||.||:|
Yeast   285 HGKDAWGVFRVHAFEKIEQFVITEP--EKSWEEFEKMISYSEEFYKSLKLPYRIVGIVSGELNNA 347

  Fly   374 ASKKLDLEAWFGGSGAYRELVSCSNCLDYQARRLLVRFGQTKKMNAAVDYVHMLNATMCAATRVI 438
            |:||.||||||.....|:||||||||.|||:|.|.:|.|..|..:....|||.||:|:.|..|.:
Yeast   348 AAKKYDLEAWFPYQKEYKELVSCSNCTDYQSRNLEIRCGIKKMGDREKKYVHCLNSTLAATQRAL 412

  Fly   439 CAILETHQTETGIKVPEPLKKYMPAKFQDEIPFVKPAPIDLELAAAEKQKGKKEKTKKD 497
            |.|||.:|||.|:.|||.|:||:|.: .:.:|||...|        :.....|:|.||:
Yeast   413 CCILENYQTEDGLVVPEVLRKYIPGE-PEFLPFVNELP--------KNSTSSKDKKKKN 462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SerRS	NP_001259982.1	PLN02678	3..476	CDD:215364	219/490 (45%)
		Seryl_tRNA_N	3..111	CDD:280549	34/107 (32%)
		SerRS_core	153..461	CDD:238393	163/321 (51%)
SES1	NP_010306.1	PLN02678	1..449	CDD:215364	219/491 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344390
Domainoid	1	1.000	219	1.000	Domainoid score	I463
eggNOG	1	0.900	-	-		E1_COG0172
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4751
Inparanoid	1	1.050	394	1.000	Inparanoid score	I322
Isobase	1	0.950	-	0	Normalized mean entropy	S479
OMA	1	1.010	-	-		QHG60616
OrthoFinder	1	1.000	-	-		FOG0004314
OrthoInspector	1	1.000	-	-		oto99747
orthoMCL	1	0.900	-	-		OOG6_100275
Panther	1	1.100	-	-	LDO	PTHR11778
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5591
SonicParanoid	1	1.000	-	-		X3050
TreeFam	1	0.960	-	-
	16	15.740