DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SerRS and Sars2

DIOPT Version :9

Sequence 1:	NP_001259982.1	Gene:	SerRS / 33518	FlyBaseID:	FBgn0031497	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_076126.2	Gene:	Sars2 / 71984	MGIID:	1919234	Length:	518	Species:	Mus musculus

Alignment Length:	425	Identity:	124/425 - (29%)
Similarity:	203/425 - (47%)	Gaps:	67/425 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 DLPADVT--KDL-------------TEIVAETLQPLTVNQ---------------------IKQL 108
            ||||.::  ::|             .|.|||.::.|..||                     .|||
Mouse    85 DLPAIISTWQELRQLREQIRSLEAEKEAVAEAVRALLANQDSDQVQKDPQYQGLRARGREIRKQL 149

  Fly   109 RVLIDDAMTENQKSLELAEQTRNTSLREVGNHLHESVPVSNDEDENRVERTFGD-----CEKRGK 168
            ..|.       .:..:|.||....:|| :.|..|...|| .||.:.||.|..|:     .:.||
Mouse   150 TPLY-------PQETQLEEQLYQQALR-LPNQTHPDTPV-GDESQARVVRVVGEKPAFSFQPRG- 204

  Fly   169 YSHVDLIVMIDGMNAEKGAVVSGGRGYFLTGAAVFLEQALIQHALHLLYARDYVPLYTPFFMRKE 233
              |:::...:|.:..::.:.|||.|.|:|.||...|:..|:...|..|.:|.:.|:..|..:|..
Mouse   205 --HLEIGEKLDIIRQKRLSHVSGHRSYYLRGAGALLQHGLVNFTLSKLVSRGFTPMTVPDLLRGA 267

  Fly   234 VMQEVAQLSQFD-EELYKVVGKGSEKAEEVGIDEKYLIATSEQPIAAYHRDEWLPESSLPIKYAG 297
            |.:........: .::|.:        :....::..|..|:|..:|.|..|..:....||::...
Mouse   268 VFEGCGMTPNANPSQIYNI--------DPSRFEDLNLAGTAEVGLAGYFMDHSVAFRDLPVRMVC 324

  Fly   298 LSTCFRQEVGSHGRDTRGIFRVHQFEKVEQFVLTSPHDNKSWEMMDEMIGNAEQFCQSLGIPYRV 362
            .|||:|.|..: |::..|::|||.|.|||.|.:|.|...:|.:::||.:....:....||:.:||
Mouse   325 ASTCYRAETDT-GKEPWGLYRVHHFTKVEMFGVTGPGLEQSSQLLDEFLSLQVEILTELGLHFRV 388

  Fly   363 VNIVSGALNHAASKKLDLEAWFGGSGAYRELVSCSNCLDYQARRLLVRFGQTKKMNAAVDYVHML 427
            :::.:..|...|.:|.|:|||..|.|.|.|:.|.|||.|:|:|||.:.| :|:  ...:.:.|.:
Mouse   389 LDMPTQELGLPAYRKFDIEAWMPGRGRYGEVTSASNCTDFQSRRLYIMF-ETE--TGELQFAHTV 450

  Fly   428 NATMCAATRVICAILETHQTETG-IKVPEPLKKYM 461
            |||.||..||:.|:||::|.:.| :.||..|:.|:
Mouse   451 NATACAVPRVLIALLESNQQKDGSVLVPAALQPYL 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SerRS	NP_001259982.1	PLN02678	3..476	CDD:215364	124/425 (29%)
		Seryl_tRNA_N	3..111	CDD:280549	15/66 (23%)
		SerRS_core	153..461	CDD:238393	96/314 (31%)
Sars2	NP_076126.2	PRK05431	67..493	CDD:235461	124/425 (29%)
		Seryl_tRNA_N	67..172	CDD:299883	21/94 (22%)
		SerRS_core	185..485	CDD:238393	96/314 (31%)
		L-serine binding. /evidence=ECO:0000250\|UniProtKB:Q9N0F3	299..301		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	497..518
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0172
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D495094at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100275
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.720