DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SerRS and sars2

DIOPT Version :9

Sequence 1:	NP_001259982.1	Gene:	SerRS / 33518	FlyBaseID:	FBgn0031497	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_957473.1	Gene:	sars2 / 394154	ZFINID:	ZDB-GENE-040426-1616	Length:	510	Species:	Danio rerio

Alignment Length:	474	Identity:	138/474 - (29%)
Similarity:	220/474 - (46%)	Gaps:	94/474 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 DVALVETVIAKDTEWRQCRHRADNLNKVKNVCSKVIGEKMKKKEPVGAMSEDLPADVTKDLTEIV 93
            ||.|:.:|      |:       ||.||:...|.:.|.|                       ::|
Zfish    85 DVPLIISV------WK-------NLQKVQEEISHLEGRK-----------------------QVV 113

  Fly    94 AETLQPLTVNQIKQLRVLIDDAMTENQKSLELAEQTRNTSLRE-------------VGNHLHESV 145
            :.|::.|.....|.....:::.....::...:.|:.....|:|             :.|..|.||
Zfish   114 SSTVRELVGKHDKSTLSSLEEYGHAREEGRAIREKLNQLYLQEKELEKEHYCRALRLPNRTHPSV 178

  Fly   146 PVSNDEDENRVERTFG-----DCEKRGKYSHVDLIVMIDGMNAEKGAVVSGGRGYFLTGAAVFLE 205
            |: .||.:.||....|     |.:.:|   |:.:...:|.:...:.:.|||.|.|:|.||...|:
Zfish   179 PI-GDESQARVVEVVGEKREFDFKPKG---HLQIGESLDIIRQRRLSHVSGHRSYYLRGAGAQLQ 239

  Fly   206 QALIQHALHLLYARDYVPLYTPFFMRKEV-----MQEVAQLSQFDEELYKVVGKGSEKAEEVGID 265
            .||...|:.||..|.::|:..|..::..|     ||..||.||    :|.:..|.|        .
Zfish   240 FALQNFAMDLLQKRGFIPMVVPDILKSVVFEGCGMQPHAQKSQ----VYSLNPKRS--------P 292

  Fly   266 EKYLIATSEQPIAAYHRDEWLPESSLPIKYAGLSTCFRQEVGSHGRDTRGIFRVHQFEKVEQF-V 329
            :..|..|.:..:|.|..|..:....||::....|||:|.|..: ||:|.|::|||.|.|:|.. |
Zfish   293 DLNLAGTGKVGVAGYFMDHAVNLKDLPVRTVCSSTCYRAETDT-GRETWGLYRVHHFTKIEMLGV 356

  Fly   330 LTSPHDNKSWEMMDEMIGNAEQFCQSLGIPYRVVNIVSGALNHAASKKLDLEAWFGGSGAYRELV 394
            ..:....:|.:::|:.:...::...||.:.|||:::.:..|...|.:|.|:|||..|.|::.|:.
Zfish   357 SANETGEESSQLLDQFVTLQKEIFSSLKLHYRVLDMPTQELGPPAYRKFDIEAWMPGRGSFGEIS 421

  Fly   395 SCSNCLDYQARRLLVRF-GQTKKMNAAVDYVHMLNATMCAATRVICAILETHQTETG-IKVPEPL 457
            |.|||.|||:|||.:|: |:..|:    .|.|.:|||.||..|.|.|||||:||:.| ::|||.|
Zfish   422 SASNCTDYQSRRLDIRYEGEDGKL----QYAHTVNATACAIPRTIIAILETYQTKKGTVQVPEVL 482

  Fly   458 K-----------KYMPAKF 465
            :           ||.|.|:
Zfish   483 QQYIGMEVIEKPKYTPIKY 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SerRS	NP_001259982.1	PLN02678	3..476	CDD:215364	138/474 (29%)
		Seryl_tRNA_N	3..111	CDD:280549	16/81 (20%)
		SerRS_core	153..461	CDD:238393	109/331 (33%)
sars2	NP_957473.1	PRK05431	58..494	CDD:235461	134/465 (29%)
		Seryl_tRNA_N	58..172	CDD:299883	19/122 (16%)
		SerRS_core	185..486	CDD:238393	108/320 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D495094at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100275
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820