DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SerRS and Sars2

DIOPT Version :9

Sequence 1:	NP_001259982.1	Gene:	SerRS / 33518	FlyBaseID:	FBgn0031497	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001099710.1	Gene:	Sars2 / 292759	RGDID:	1309456	Length:	518	Species:	Rattus norvegicus

Alignment Length:	440	Identity:	122/440 - (27%)
Similarity:	207/440 - (47%)	Gaps:	57/440 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 VIAKDTEWRQCRHRADNLNKVKNVCSKVIGEKMKK-------KEPVGAMSEDLPADVTKDLTEIV 93
            :|:...|.||.|.:..:|...|...::.:...:.|       |:|..........::.|.||
  Rat    89 IISTWQELRQLREQIQSLEAEKEAVAEAVRALLAKQDSNQVQKDPQYQGLRTRGREIRKQLT--- 150

  Fly    94 AETLQPLTVNQIKQLRVLIDDAMTENQKSLELAEQTRNTSLREVGNHLHESVPVSNDEDENRVER 158
              .|.|                     :..:|.|:....:|| :.|..|...|| .||.:.||.|
  Rat   151 --PLYP---------------------RETQLEEEFYQQALR-LPNQTHPDTPV-GDESQARVLR 190

  Fly   159 TFGD-----CEKRGKYSHVDLIVMIDGMNAEKGAVVSGGRGYFLTGAAVFLEQALIQHALHLLYA 218
            ..||     .:.||   |:::...:|.:..::.:.|||.|.|:|.||...|:..|:...|..|.:
  Rat   191 VVGDKPAFSFQPRG---HLEIGEKLDIIRQKRLSHVSGHRSYYLRGAGALLQHGLVNFTLSKLVS 252

  Fly   219 RDYVPLYTPFFMRKEVMQEVAQLSQFD-EELYKVVGKGSEKAEEVGIDEKYLIATSEQPIAAYHR 282
            |.:.|:..|..:|..|.:........: .::|.:        :....::..|..|:|..:|.|..
  Rat   253 RGFTPMTVPDLLRGAVFEGCGMTPNANPSQIYNI--------DPSRFEDLNLAGTAEVGLAGYFM 309

  Fly   283 DEWLPESSLPIKYAGLSTCFRQEVGSHGRDTRGIFRVHQFEKVEQFVLTSPHDNKSWEMMDEMIG 347
            |..:....||::....|||:|.|..: |::..|::|||.|.|||.|.:|.|...:|.::::|.:.
  Rat   310 DHAVASRDLPVRMVCASTCYRAETDT-GKEPWGLYRVHHFAKVEMFGVTGPGLEQSSQLLEEFLS 373

  Fly   348 NAEQFCQSLGIPYRVVNIVSGALNHAASKKLDLEAWFGGSGAYRELVSCSNCLDYQARRLLVRFG 412
            ...:....||:.:||:::.:..|...|.:|.|:|||..|.|.|.|:.|.|||.|:|:|||.:.|
  Rat   374 LQVEILTELGLHFRVLDMPTQELGLPAYRKFDIEAWMPGRGRYGEVTSASNCTDFQSRRLYIMF- 437

  Fly   413 QTKKMNAAVDYVHMLNATMCAATRVICAILETHQTETG-IKVPEPLKKYM 461
            :|:  ...:.:.|.:|||.||..||:.|:||::|.:.| :.||..|:.|:
  Rat   438 ETE--TGELQFAHTVNATACAVPRVLIALLESNQQKDGSVLVPAALQPYL 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SerRS	NP_001259982.1	PLN02678	3..476	CDD:215364	122/440 (28%)
		Seryl_tRNA_N	3..111	CDD:280549	15/81 (19%)
		SerRS_core	153..461	CDD:238393	96/314 (31%)
Sars2	NP_001099710.1	PRK05431	67..493	CDD:235461	122/440 (28%)
		Seryl_tRNA_N	67..172	CDD:299883	19/109 (17%)
		SerRS_core	185..485	CDD:238393	96/314 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0172
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D495094at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100275
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.720