DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SerRS and SPAC29A4.15

DIOPT Version :9

Sequence 1:	NP_001259982.1	Gene:	SerRS / 33518	FlyBaseID:	FBgn0031497	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_594867.1	Gene:	SPAC29A4.15 / 2542163	PomBaseID:	SPAC29A4.15	Length:	450	Species:	Schizosaccharomyces pombe

Alignment Length:	499	Identity:	231/499 - (46%)
Similarity:	299/499 - (59%)	Gaps:	60/499 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 VLDLDLFRSDKGGNPDLVRENQKKRFKDVALVETVIAKDTEWRQCRHRADNLNKVKNVCSKVIGE 66
            :||::||:.:|||||:::||:|:||..||.:|:.||....||...|...||.||..|...|.||.
pombe     1 MLDINLFQVEKGGNPEIIRESQRKRGADVGVVDKVIEMYKEWVSLRFELDNTNKSINRVQKEIGL 65

  Fly    67 KMKKKEPVGAMSEDLPADVTKDLTEIVAETLQPLTVNQIKQLRVLIDDAMTENQKSLELAEQTRN 131
            |||.||               |.:|::.|                 .:::||.:|:|...|..:|
pombe    66 KMKAKE---------------DASELLEE-----------------KNSLTERKKNLIEQETAKN 98

  Fly   132 TSL----REVGNHLHESVPVSNDEDENRVERTFG----DCEKRGKYSHVDLIVMIDGMNAEKGAV 188
            ..:    ..:||.:|:|||||.|||.|.:.|.:.    ..||:...||.:::..:||.:.|:|..
pombe    99 KEMLNVVSSIGNIVHDSVPVSMDEDNNEIIRKWAPEGVTVEKKNCLSHHEVLTRLDGYDPERGVK 163

  Fly   189 VSGGRGYFLTGAAVFLEQALIQHALHLLYARDYVPLYTPFFMRKEVMQEVAQLSQFDEELYKVVG 253
            |||.|||||....||...||||:.|..|..|.|:.|..|..:.|:||.:.|||.|||||||||:.
pombe   164 VSGHRGYFLRQYGVFFNLALIQYGLDFLEKRGYIALQAPTMLNKDVMAKTAQLEQFDEELYKVID 228

  Fly   254 KGSEKAEEVGIDEKYLIATSEQPIAAYHRDEWL--PESSLPIKYAGLSTCFRQEVGSHGRDTRGI 316
                     |.:|:||||||||||:|||..||.  |...||:||||.|||:|:|.||||||..||
pombe   229 ---------GDEERYLIATSEQPISAYHSGEWFEKPSEQLPLKYAGYSTCYRREAGSHGRDAWGI 284

  Fly   317 FRVHQFEKVEQFVLTSPHDNKSWEMMDEMIGNAEQFCQSLGIPYRVVNIVSGALNHAASKKLDLE 381
            ||||.|||:||||||.|  .||||...|||.:||.|.:||.:|||:|.|||||||:||:||.|||
pombe   285 FRVHAFEKIEQFVLTDP--EKSWEAFTEMINHAEDFYKSLELPYRIVAIVSGALNNAAAKKYDLE 347

  Fly   382 AWFGGSGAYRELVSCSNCLDYQARRLLVRFGQTKKMNAAVDYVHMLNATMCAATRVICAILETHQ 446
            |||...|.|:||||||||.|||:|.|.:|.|..|..:....|||.||:|:||..|.:|.|||.:|
pombe   348 AWFPFQGEYKELVSCSNCTDYQSRNLEIRCGVKKMGDREKKYVHCLNSTLCATERALCCILENYQ 412

  Fly   447 TETGIKVPEPLKKYMPAKFQDEIPFVKPAPIDLELAAAEKQKGK 490
            |..|:.||:.|:.||..|  ..:||.|..|.:     :..:|||
pombe   413 TPDGVNVPKVLQPYMGGK--TFLPFTKELPKN-----STSKKGK 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SerRS	NP_001259982.1	PLN02678	3..476	CDD:215364	227/482 (47%)
		Seryl_tRNA_N	3..111	CDD:280549	38/107 (36%)
		SerRS_core	153..461	CDD:238393	166/313 (53%)
SPAC29A4.15	NP_594867.1	PLN02678	1..450	CDD:215364	231/499 (46%)
		Seryl_tRNA_N	2..112	CDD:280549	46/141 (33%)
		SerRS_core	124..427	CDD:238393	166/313 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	232	1.000	Domainoid score	I495
eggNOG	1	0.900	-	-		E1_COG0172
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4751
Inparanoid	1	1.050	407	1.000	Inparanoid score	I368
OMA	1	1.010	-	-		QHG60616
OrthoFinder	1	1.000	-	-		FOG0004314
OrthoInspector	1	1.000	-	-		oto101407
orthoMCL	1	0.900	-	-		OOG6_100275
Panther	1	1.100	-	-	LDO	PTHR11778
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5591
SonicParanoid	1	1.000	-	-		X3050
TreeFam	1	0.960	-	-
	14	13.860