DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SerRS and SPAC25B8.06c

DIOPT Version :9

Sequence 1:	NP_001259982.1	Gene:	SerRS / 33518	FlyBaseID:	FBgn0031497	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_594466.2	Gene:	SPAC25B8.06c / 2541567	PomBaseID:	SPAC25B8.06c	Length:	479	Species:	Schizosaccharomyces pombe

Alignment Length:	445	Identity:	134/445 - (30%)
Similarity:	217/445 - (48%)	Gaps:	57/445 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 RQCRHRADNLNKVKNVCSKV---IGEKMKKKE---PVGAMSEDLPADVTKDLTEIVAETLQPLTV 102
            |.|.:|  ||..:.....|:   |.||...|.   |:.::.:::              |||....
pombe    64 RNCINR--NLQAIAETVPKIRSLIDEKESLKNEFFPLLSLKKEI--------------TLQIERC 112

  Fly   103 NQIKQLRVLIDDAMTENQKSLELAEQTRNTSLREVGNHLHE-----------SVPVSNDEDENRV 156
            :...:...|:::|     |.|:...:..|..:.:|.|.|::           :||| ..||:..|
pombe   113 SDPNERGKLVNEA-----KGLKKKTEEYNKIISKVTNDLYQYCLAVPNTTLPTVPV-GPEDKAVV 171

  Fly   157 ERTFGD--CEKRGKYSHVDLIVMIDGMNAEKGAVVSGGRGYFLTGAAVFLEQALIQHALHLLYAR 219
            .:..|.  .:|.|.... .|.:..:|:|.|..|..||....:.||....||.|:..:|:....::
pombe   172 VQKIGSPLVKKTGSLKD-HLQIANEGINLEDAAQASGHSFCYTTGDIALLEMAITNYAMDFAISK 235

  Fly   220 DYVPLYTPFFMRKEVMQEVAQLSQF---DEELYKVVGKGSEKAEEVGIDEKYLIATSEQPIAAYH 281
            .:.|:..|..:|    .::|....|   |||..::....|..:..|...::.||.|:|..:||..
pombe   236 GWCPVIPPTIVR----TDIALACGFQPRDEEGQQIYELDSYTSPLVSSPKQCLIGTAEISLAALG 296

  Fly   282 RDEWLPESSLPIKYAGLSTCFRQEVGSHGRDTRGIFRVHQFEKVEQFVLTSPHDNKSWEMMDEMI 346
            ..:.. .:....|..|:|..:|:|.|:.|::.||::|:|:|.|||.|..|  |.::|.||.:|::
pombe   297 FKKTF-NNFTERKVVGVSRAYRREAGARGKENRGLYRLHEFTKVELFAWT--HPSRSSEMFNEIV 358

  Fly   347 GNAEQFCQSLGIPYRVVNIVSGALNHAASKKLDLEAWFGGSGAYRELVSCSNCLDYQARRLLVRF 411
            ...::|.::|.||.|::|:.:..|..:||:|.|:|||.....:|.|:.|.||||:|||||||.|:
pombe   359 NFQKEFVETLKIPARILNMPTAELGSSASQKYDIEAWMPARQSYGEITSASNCLEYQARRLLTRY 423

  Fly   412 GQTKKMNAAVDYVHMLNATMCAATRVICAILETHQTETG-IKVPEPLKKYMPAKF 465
            ...|...    :||.||.|..|..|:|.||||.||.|.| :||||.|..|:..::
pombe   424 RNDKDSG----FVHTLNGTAAAIPRLIIAILENHQQEDGTVKVPETLVPYIHKEY 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SerRS	NP_001259982.1	PLN02678	3..476	CDD:215364	134/445 (30%)
		Seryl_tRNA_N	3..111	CDD:280549	14/72 (19%)
		SerRS_core	153..461	CDD:238393	106/313 (34%)
SPAC25B8.06c	NP_594466.2	SerS	49..479	CDD:223250	134/445 (30%)
		Seryl_tRNA_N	50..156	CDD:280549	22/112 (20%)
		SerRS_core	169..470	CDD:238393	106/312 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0172
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100275
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.710