DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GABPI and AKR2

DIOPT Version :9

Sequence 1:	NP_608741.1	Gene:	GABPI / 33516	FlyBaseID:	FBgn0031495	Length:	420	Species:	Drosophila melanogaster
Sequence 2:	NP_014677.1	Gene:	AKR2 / 854199	SGDID:	S000005560	Length:	749	Species:	Saccharomyces cerevisiae

Alignment Length:	219	Identity:	48/219 - (21%)
Similarity:	85/219 - (38%)	Gaps:	52/219 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 FIVPLMLG--LATLNSKTAIVLML-TLVGFTIWGM---ELAKRTATRTNFFLSWLVFSVFYMII- 163
            :::.|:|.  ||.:.|....|:|: ||..|.:..:   ...|.:.|||.|| |.|..|.|..:|
Yeast   314 YLISLVLSPVLAIMLSLLVTVVMVNTLKKFVLPCLPRKNTYKVSLTRTPFF-SGLFLSTFCFLIY 377

  Fly   164 -----IFEFQVPLLELAPEENYALMFFSCAALYCLYSAKALSPLNLVSAQYGTTPKDELPGIAEA 223
                 ::.:.|....: ....:.:..|....|:          |.||.:..|....|
Yeast   378 IWTKKLYPYSVSDYTM-KNVQFLVTSFLTVVLF----------LRLVRSDPGCLKTD-------- 423

  Fly   224 SSGEEQAEAQTTLQMESVLSLDDDEVGDMDTAERSGLMHGQPNICEICRKVTPRRAYHCPVCGTC 288
                   ::.|::| |::..|.|  :|..|          :.|.|....:..|.|:.:....|..
Yeast   424 -------DSLTSIQ-ETIKQLID--LGKFD----------RENFCVETLERKPLRSKYSFFSGAL 468

  Fly   289 VKRRDHHSYWLNCCIGERNYVWYI 312
            |.|.||:..|:...:|.:|:..::
Yeast   469 VARYDHYCPWIYNDVGLKNHKLFV 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABPI	NP_608741.1	zf-DHHC	262..399	CDD:279823	12/51 (24%)
AKR2	NP_014677.1	ANKYR	1..195	CDD:223738
		ANK repeat	54..81	CDD:293786
		ANK repeat	83..115	CDD:293786
		ANK repeat	117..148	CDD:293786
		ANK repeat	189..220	CDD:293786
		Ank_4	190..243	CDD:372654
		ANK repeat	222..247	CDD:293786
		COG5273	340..711	CDD:227598	40/193 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810