DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GABPI and Zdhhc4

DIOPT Version :9

Sequence 1:	NP_608741.1	Gene:	GABPI / 33516	FlyBaseID:	FBgn0031495	Length:	420	Species:	Drosophila melanogaster
Sequence 2:	NP_082655.1	Gene:	Zdhhc4 / 72881	MGIID:	1920131	Length:	343	Species:	Mus musculus

Alignment Length:	375	Identity:	92/375 - (24%)
Similarity:	132/375 - (35%)	Gaps:	132/375 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 FDLVCTRLVTCRAIDRRNIDGMLIAFQDRLRLPWRGGAK---RISPAAVAPAFIVPLMLGLATLN 118
            |.|:|..|: |           :.....||:....|||:   |:.|..:..| :..|:..|....
Mouse    13 FLLICVVLI-C-----------IFTKSQRLKAVVLGGAQVCSRVIPQCLQRA-VQTLLHQLFHTR 64

  Fly   119 SKTAIVLMLTLVGFTIWGMELAKRTATRTNFFLSWLVFSVFYMIIIFEFQVPLLELAPEENYALM 183
            ..|.|||.|.|     .|:..|:.|.            .||......||.:|.| |.|   |.|:
Mouse    65 HPTFIVLHLLL-----QGLVYAEYTC------------EVFGYCRELEFSLPYL-LLP---YVLL 108

  Fly   184 -----FF--SCAALYCLYSAKALSPLNLVSAQYGTTPKDELPGIAEASSGEEQAEAQTTLQMESV 241
                 ||  :|||          :|        ||..|               |.....||   |
Mouse   109 SVNLVFFTLTCAA----------NP--------GTITK---------------ANESFLLQ---V 137

  Fly   242 LSLDDDEVGDMDTAERSGLMHGQPNICEICRKVTPRRAYHCPVCGTCVKRRDHHSYWLNCCIGER 306
            ...||             :|..:.:.|..|....|.|:.||.:|..||.|.|||..|:|.|||..
Mouse   138 YKFDD-------------VMFPKNSRCPTCDLRKPARSKHCRLCDRCVHRFDHHCVWVNNCIGAW 189

  Fly   307 NYVWYIVGLALSEIALLLGANLTLTSICHPFMV----VRPLGYPVLLPDDCSEVFEGFD------ 361
            |..::::.|     ..|..:..|:.::...|::    |..| |.....||... |:..|
Mouse   190 NTRYFLIYL-----LTLTASAATIATVTAAFLLRLVTVSDL-YQETYLDDVGH-FQAVDTVFLIQ 247

  Fly   362 -LGISF--------VVACYALLISSYIAFILARQAYL---------WWKG 393
             |.::|        .|...::|::.|:.|.|    ||         |:||
Mouse   248 HLFLAFPRIVFLLGFVIVLSMLLAGYLCFAL----YLAATNQTTNEWYKG 293

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABPI	NP_608741.1	zf-DHHC	262..399	CDD:279823	42/160 (26%)
Zdhhc4	NP_082655.1	DHHC	151..292	CDD:396215	40/151 (26%)
Zdhhc4	NP_082655.1	Di-lysine motif. /evidence=ECO:0000250\|UniProtKB:Q9NPG8	340..343
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810