DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GABPI and Zdhhc2

DIOPT Version :9

Sequence 1:	NP_608741.1	Gene:	GABPI / 33516	FlyBaseID:	FBgn0031495	Length:	420	Species:	Drosophila melanogaster
Sequence 2:	NP_848482.1	Gene:	Zdhhc2 / 70546	MGIID:	1923452	Length:	366	Species:	Mus musculus

Alignment Length:	323	Identity:	71/323 - (21%)
Similarity:	117/323 - (36%)	Gaps:	97/323 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 GGAKRISPAAV--APAFIVPLMLGLATLNSKTAIVLMLTLVGFTIWGMELAKRTATRTNFFLSWL 154
            ||.:|.....:  .|...:.|:||.    |..|..:.|.:|.....|.::....|..       |
Mouse     7 GGVRRRCRRVLYWIPVVFISLLLGW----SYYAYAIQLCIVSMENIGEQVVCLMAYH-------L 60

  Fly   155 VFSVF---YMIIIFEFQVPLLELAPEENYALMFFSCAALYCLYSAKALSPLNLVSAQYGTTPKDE 216
            :|::|   |...||     .|.:.|.:.:.|.          |:.|
Mouse    61 LFAMFVWSYWKTIF-----TLPMNPSKEFHLS----------YAEK------------------- 91

  Fly   217 LPGIAEASSGEEQAEA-QTTLQMESVLSLDDDEVGDMDTAERSGLMHGQPNICEICRKVTPRRAY 280
                 |....|.:.|| |..|:..:         .|:....|:  |.|....|:.|:.:.|.|.:
Mouse    92 -----ELLEREPRGEAHQEVLRRAA---------KDLPIYTRT--MSGAIRYCDRCQLIKPDRCH 140

  Fly   281 HCPVCGTCVKRRDHHSYWLNCCIGERNYVWYIVGLALSEIALLLGANLTLTSICHPFMVVRPLGY 345
            ||.||..|:.:.|||..|:|.|:|..||.::::.||.|.:..|             |:....|.|
Mouse   141 HCSVCDKCILKMDHHCPWVNNCVGFSNYKFFLLFLAYSLLYCL-------------FIAATDLQY 192

  Fly   346 PVL-----LPDDCSEVFEGFDLGISFVVACYALLISSYIAFILARQAYLWW---KGSTLHEYK 400
            .:.     |||..::....|   :.|..|.:::.:||...:      :.|.   ..|||..::
Mouse   193 FIRFWTNGLPDTQAKFHIMF---LFFAAAMFSVSLSSLFGY------HCWLVSKNKSTLEAFR 246

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABPI	NP_608741.1	zf-DHHC	262..399	CDD:279823	38/144 (26%)
Zdhhc2	NP_848482.1	DHHC	126..247	CDD:366691	37/143 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	296..366
		Mediates localization to plasma membrane and recycling endosomes. /evidence=ECO:0000269\|PubMed:21471008	298..366
		Non-canonical dileucine endocytic signal. /evidence=ECO:0000269\|PubMed:28768144	334..335
		NPxY-like endocytic signal. /evidence=ECO:0000269\|PubMed:28768144	357..360
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810