DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GABPI and ZDHHC13

DIOPT Version :9

Sequence 1:	NP_608741.1	Gene:	GABPI / 33516	FlyBaseID:	FBgn0031495	Length:	420	Species:	Drosophila melanogaster
Sequence 2:	NP_061901.2	Gene:	ZDHHC13 / 54503	HGNCID:	18413	Length:	622	Species:	Homo sapiens

Alignment Length:	321	Identity:	77/321 - (23%)
Similarity:	118/321 - (36%)	Gaps:	97/321 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   120 KTAIVLMLTLVGFTIWGME----------LAKRTATRTNFFL-------------------SWLV 155
            |..:.|:|.|...|:|.:.          |.|.....|.|||                   ::|:
Human   289 KCELFLLLMLSVITMWAIGYILDFNSDSWLLKGCLLVTLFFLTSLFPRFLVGYKNLVYLPTAFLL 353

  Fly   156 FSVFYMIIIFEFQVPLLELAPEENYALMFFSCAA-LYCLYSAKALSPLNLVSAQYGTTPKDELPG 219
            .|||::.:.: |.:...:||....|....||..| ||..|...|..                 ||
Human   354 SSVFWIFMTW-FILFFPDLAGAPFYFSFIFSIVAFLYFFYKTWATD-----------------PG 400

  Fly   220 IAEASSGEEQAEAQTTLQMESVLSLDDDEVGDMDTAERSGLMHGQPNICEICRKVTPRRAYHCPV 284
            ..:||..|::.         ::::|  .|.|.:|..          ..|..|....|.|:.||.|
Human   401 FTKASEEEKKV---------NIITL--AETGSLDFR----------TFCTSCLIRKPLRSLHCHV 444

  Fly   285 CGTCVKRRDHHSYWLNCCIGERNYVWYIVGLALSEIALLLGANLTLTSICHPFMVVRPLGYPVLL 349
            |..||.|.|.|..|...|||..|:.:||..|            ..|:.:|...:    .|..:.|
Human   445 CNCCVARYDQHCLWTGRCIGFGNHHYYIFFL------------FFLSMVCGWII----YGSFIYL 493

  Fly   350 PDDCSEVF--EGFDLGISFVVAC-----YALLIS----SYIAFILARQAY-LWWKGSTLHE 398
            ...|:..|  :|....::.:|||     |.|:::    |:..|:|..|.: :.:.|.|.||
Human   494 SSHCATTFKEDGLWTYLNQIVACSPWVLYILMLATFHFSWSTFLLLNQLFQIAFLGLTSHE 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABPI	NP_608741.1	zf-DHHC	262..399	CDD:279823	41/149 (28%)
ZDHHC13	NP_061901.2	ANK 1. /evidence=ECO:0000250\|UniProtKB:Q8IUH5	43..78
		ANK	79..192	CDD:238125
		ANK repeat	81..112	CDD:293786
		ANK 2. /evidence=ECO:0000255	81..110
		ANK repeat	114..146	CDD:293786
		ANK 3. /evidence=ECO:0000255	115..144
		ANKYR	<145..271	CDD:223738
		ANK repeat	148..179	CDD:293786
		ANK 4. /evidence=ECO:0000255	148..177
		ANK repeat	181..247	CDD:293786
		ANK 5. /evidence=ECO:0000255	181..211
		ANK 6. /evidence=ECO:0000255	216..245
		ANK 7. /evidence=ECO:0000255	249..277
		zf-DHHC	423..559	CDD:307600	42/158 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810