DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GABPI and zdhhc23b

DIOPT Version :9

Sequence 1:	NP_608741.1	Gene:	GABPI / 33516	FlyBaseID:	FBgn0031495	Length:	420	Species:	Drosophila melanogaster
Sequence 2:	NP_001003757.1	Gene:	zdhhc23b / 445301	ZFINID:	ZDB-GENE-040808-13	Length:	425	Species:	Danio rerio

Alignment Length:	441	Identity:	118/441 - (26%)
Similarity:	185/441 - (41%)	Gaps:	99/441 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 LCCCEYVAEDSRERSHILGCCCNCVDFDLVCTRLVTCRAIDRRNIDGMLIAFQDRLRLPWRGGAK 95
            ||||||: :....|||::.|||:|.|.|..|.|.:.....:..::...|....||||:||..||:
Zfish    15 LCCCEYI-DRHGSRSHMVACCCDCEDLDEACDRWMNKEPQNPDSVSRALATINDRLRVPWISGAR 78

  Fly    96 RISPAAVAPAFIVPLMLGLATLNSKTAIVLMLTLVGFTI-WGMELAKRTATRTNFFLSWLVFSVF 159
            :|..:.:.|..::|:.|.:|.|:....|: |||.:..|: |......|...||.|||...:||:|
Zfish    79 QIDVSLIPPLILLPVFLHIAALHYLLGII-MLTAMPITVLWYYFFTHRKKGRTLFFLGLALFSLF 142

  Fly   160 YMIIIFEFQVPLLELAPEENYALMFFSCAALYCLYSAKALSPLNLVSAQYGTTPKDELPGIAEAS 224
            ||..:|     |.::.|......:     .|..:.:..||:.:.|:..:.|       ||:..
Zfish   143 YMFYLF-----LTQVVPRGEVTEL-----QLAVVTAGVALTVIFLMLTKRG-------PGLVR-- 188

  Fly   225 SGEEQAEAQTTLQMESVLSLDDDEVGDMDTAERSGLMH--------------GQP---------- 265
              ...:|..:|:...|.       ..|:|....:|..|              |:|
Zfish   189 --PRPSETHSTVTYHST-------PPDVDGVYLNGARHQVVIGSRVASSEHTGEPGTEEEEEGVQ 244

  Fly   266 --NICEICRKVTPRRAYHCPVCGTCVKRRDHHSYWLNCCIGERNYVWYIVGLALSEIALLLGANL 328
              |.|.:|:.|.||||.||.:||.||.|.|||..|:|.|:|..|:..:::.|....:..:.|.:|
Zfish   245 KRNWCAVCKVVRPRRAGHCRICGVCVLRLDHHCVWINSCVGLANHRTFLLTLLFFLLTSIFGISL 309

  Fly   329 TLTSICHPFMVVRPLGYPVLLPDDCSEVFEGFDLGISFVVACYALLISSYIAFIL---------- 383
            .|.|:|....|:..|.|       |.:|:..:...:.|..|.|:.:::..:..:|
Zfish   310 VLASVCPDQRVLTALFY-------CPDVYSQYSSALCFTCAWYSSIVTGGLLHLLLLQILNISLN 367

  Fly   384 -------------ARQAYLWWKGSTLH--EYKRTSNAAGRNRIWSNWRAIL 419
                         :.|..||  |..:|  .|.|        ..||||...|
Zfish   368 VTEREARLALREKSAQRRLW--GLIVHTGHYSR--------GFWSNWTEFL 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABPI	NP_608741.1	zf-DHHC	262..399	CDD:279823	46/187 (25%)
zdhhc23b	NP_001003757.1	7TMR-DISM_7TM	<62..179	CDD:284997	39/127 (31%)
zdhhc23b	NP_001003757.1	zf-DHHC	<244..>350	CDD:303066	37/112 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578059
Domainoid	1	1.000	101	1.000	Domainoid score	I6890
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H17840
Inparanoid	1	1.050	161	1.000	Inparanoid score	I4206
OMA	1	1.010	-	-		QHG48693
OrthoDB	1	1.010	-	-		D1261879at2759
OrthoFinder	1	1.000	-	-		FOG0006883
OrthoInspector	1	1.000	-	-		otm26025
orthoMCL	1	0.900	-	-		OOG6_109191
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5590
SonicParanoid	1	1.000	-	-		X4988
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.700