DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GABPI and Hip14

DIOPT Version :9

Sequence 1:	NP_608741.1	Gene:	GABPI / 33516	FlyBaseID:	FBgn0031495	Length:	420	Species:	Drosophila melanogaster
Sequence 2:	NP_001261910.1	Gene:	Hip14 / 39747	FlyBaseID:	FBgn0259824	Length:	655	Species:	Drosophila melanogaster

Alignment Length:	281	Identity:	66/281 - (23%)
Similarity:	106/281 - (37%)	Gaps:	66/281 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 FTIWGMELAKRTATRTNFFLSWLVFSVFYMIIIFEFQVPLLELAPEENYA----------LMFF- 185
            |.:.|:.....|.....|||...::|:|:.|....|...|:.|.|...|.          ||:.
  Fly   307 FYLAGIVFTVNTLYIIKFFLLGCLYSIFHTIGKALFDEHLMALLPLSVYLATKAWFYVTWLMYID 371

  Fly   186 ---SCAALYCLYSAKALSPLNLVSAQYGTTPKDELPGIAEASSGEEQAEAQTTLQMESVLSLDDD 247
               |..|..|...:..|..:..:.:..|.      |||...:  .||       :.::::.|
  Fly   372 DAVSFTATVCFLISSLLLWVCFLKSWKGD------PGIIRPT--REQ-------RFKTIIEL--- 418

  Fly   248 EVGDMDTAERSGLMHGQPNICEICRKVTPRRAYHCPVCGTCVKRRDHHSYWLNCCIGERNYVWYI 312
                   :||.|:.....:.|..|....|.|:.||.||..||.|.|||..|:..|||.:|:.::
  Fly   419 -------SERGGIGFEPASFCSGCLVRRPIRSKHCSVCDRCVARFDHHCPWVGNCIGLKNHSYF- 475

  Fly   313 VGLALSEIALLLGANLTLTSICHPFMVVRPLGYPVLLPDDCSEVFEGF----------DLGISFV 367
                       :|....|..:| .:|:.....|.|   :.|:..|:.|          |..:.:|
  Fly   476 -----------MGFLWMLLIMC-AWMLYGGSKYYV---NQCNVRFDDFLGAMRAIGNCDAWVGWV 525

  Fly   368 VACYALLISSYIAFILARQAY 388
            :. .|||..|::..:...|.|
  Fly   526 MG-NALLHMSWVILLTICQTY 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABPI	NP_608741.1	zf-DHHC	262..399	CDD:279823	36/137 (26%)
Hip14	NP_001261910.1	ANK	52..165	CDD:238125
		Ank_2	52..142	CDD:289560
		ANK repeat	77..108	CDD:293786
		ANK repeat	110..142	CDD:293786
		ANK	114..233	CDD:238125
		Ank_2	116..209	CDD:289560
		ANK repeat	144..175	CDD:293786
		ANK repeat	177..209	CDD:293786
		Ank_5	198..251	CDD:290568
		ANK repeat	212..244	CDD:293786
		zf-DHHC	426..559	CDD:279823	36/137 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810