DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GABPI and Zdhhc23

DIOPT Version :9

Sequence 1:	NP_608741.1	Gene:	GABPI / 33516	FlyBaseID:	FBgn0031495	Length:	420	Species:	Drosophila melanogaster
Sequence 2:	NP_001007461.1	Gene:	Zdhhc23 / 332175	MGIID:	2685625	Length:	425	Species:	Mus musculus

Alignment Length:	378	Identity:	112/378 - (29%)
Similarity:	190/378 - (50%)	Gaps:	34/378 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 EESKSKENGSLCCCEYVAEDSRERSHILGCCCNCVDFDLVCTRLVTCRAIDRRNIDGMLIAFQDR 85
            ::::..|...||||||: :.:.|::|:..|.|:|.|.|..|.|.:||:::.....:.:.....||
Mouse     7 KKTEEPELEPLCCCEYI-DRNGEKNHVAACLCDCQDLDEGCDRWLTCQSLRPETCERITDTISDR 70

  Fly    86 LRLPWRGGAKRISPAAVAPAFIVPLMLGLATLNSKTAIVLMLTLVGFTIWGMELAKRTATRTNFF 150
            ||:||..|||:::.:.|.|..::|:.|.:|:.:....:|::.:|....:|...|..|...:|.||
Mouse    71 LRIPWLRGAKKVNISIVPPLVLLPVFLHVASWHFLLGVVVLTSLPMLALWYYYLTHRRKEQTLFF 135

  Fly   151 LSWLVFSVFYMIIIFEFQVPLLELAPEENYA---LMFFSCA---ALYCLYSAKALSPLNLVSAQY 209
            ||..:||:.||..:|     |.|:.|:....   |...:|.   .|..||.||. :|..|.:.:.
Mouse   136 LSLGLFSLGYMYYVF-----LREVVPQGRVGPTQLALLTCGLLLILLALYRAKK-NPGYLSNDKS 194

  Fly   210 GTTPKDELPGIAEASSGEEQAEAQTTLQMESVL---SLDDDEVGDMDTAERSGL---MHGQPNIC 268
            .:..:.|.|    ...|:|:.:..........|   :|.||..|    :.|.||   ...:.:.|
Mouse   195 PSNSQIECP----VKKGQEKTKGFPGTDASGSLNNRTLKDDVRG----SSRVGLDSPAKVKEDWC 251

  Fly   269 EICRKVTPRRAYHCPVCGTCVKRRDHHSYWLNCCIGERNYVWYIVGLALSEIALLLGANLTLTSI 333
            ..|:.|.|.||:||.:||.||:|.|||..|:|.|:||.|:..:|:.|::..:..:.|.:|||.:|
Mouse   252 AKCQLVRPARAWHCRICGICVRRMDHHCVWINSCVGESNHQAFILALSIFLLTSVYGISLTLNTI 316

  Fly   334 CHPFMVVRPLGYPVLLPDDCSEVFEGFDLGISFVVACYALLISSYIAFILARQ 386
            |....:...|.|       |..|:..:...:||....|:::|::.:|:|...|
Mouse   317 CRDRSLFTALFY-------CPGVYANYSSALSFTCVWYSVIITAGMAYIFLIQ 362

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABPI	NP_608741.1	zf-DHHC	262..399	CDD:279823	41/125 (33%)
Zdhhc23	NP_001007461.1	DHHC	248..374	CDD:396215	41/122 (34%)
Zdhhc23	NP_001007461.1	Interaction with NOS1. /evidence=ECO:0000250	422..425
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834959
Domainoid	1	1.000	102	1.000	Domainoid score	I6836
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H17840
Inparanoid	1	1.050	177	1.000	Inparanoid score	I4024
Isobase	1	0.950	-	0	Normalized mean entropy	S4031
OMA	1	1.010	-	-		QHG48693
OrthoDB	1	1.010	-	-		D519878at33208
OrthoFinder	1	1.000	-	-		FOG0006883
OrthoInspector	1	1.000	-	-		oto95140
orthoMCL	1	0.900	-	-		OOG6_109191
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5590
SonicParanoid	1	1.000	-	-		X4988
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.650