DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GABPI and ZDHHC1

DIOPT Version :9

Sequence 1:	NP_608741.1	Gene:	GABPI / 33516	FlyBaseID:	FBgn0031495	Length:	420	Species:	Drosophila melanogaster
Sequence 2:	NP_037436.1	Gene:	ZDHHC1 / 29800	HGNCID:	17916	Length:	485	Species:	Homo sapiens

Alignment Length:	268	Identity:	62/268 - (23%)
Similarity:	104/268 - (38%)	Gaps:	59/268 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   151 LSWLVFSVFYMIIIFEFQVPLLELAPEENYALMFFSCAALYCLYSAKALSPLNLVSAQYGTTPKD 215
            ::||:: :|:.:|.|...||||    ..::....::|  :..:::...:..|..||.
Human    54 VAWLLY-LFFAVIGFGILVPLL----PHHWVPAGYAC--MGAIFAGHLVVHLTAVSI-------- 103

  Fly   216 ELPGIAEASSGEEQAEAQTTLQMESVLSLDDDEVGDMDTAERSGLMHGQPNI-CEICRKVTPRRA 279
                        :.|:|...         |....|.:....||...|...:: |.:|......|:
Human   104 ------------DPADANVR---------DKSYAGPLPIFNRSQHAHVIEDLHCNLCNVDVSARS 147

  Fly   280 YHCPVCGTCVKRRDHHSYWLNCCIGERNYVWYIVGLALSEIALLLGANLTLTSICHPFM--VVRP 342
            .||..|..||...|||..|||.|:|||||..::..:|    :.|||..|.:....:.|:  .|.|
Human   148 KHCSACNKCVCGFDHHCKWLNNCVGERNYRLFLHSVA----SALLGVLLLVLVATYVFVEFFVNP 208

  Fly   343 LG----------------YPVLLPDDCSEVFEGFDLGISFVVACYALLISSYIAFILARQAYLWW 391
            :.                :.|.||....|......|.::.::....||.::.:..:|....||.|
Human   209 MRLRTNRHFEVLKNHTDVWFVFLPAAPVETQAPAILALAALLILLGLLSTALLGHLLCFHIYLMW 273

  Fly   392 KGSTLHEY 399
            ...|.:||
Human   274 HKLTTYEY 281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABPI	NP_608741.1	zf-DHHC	262..399	CDD:279823	41/155 (26%)
ZDHHC1	NP_037436.1	Mediates interaction with STING1. /evidence=ECO:0000269\|PubMed:25299331	1..271		56/256 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..41
		zf-DHHC	129..284	CDD:307600	43/157 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	324..358
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	462..485
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810