DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GABPI and akr1

DIOPT Version :9

Sequence 1:	NP_608741.1	Gene:	GABPI / 33516	FlyBaseID:	FBgn0031495	Length:	420	Species:	Drosophila melanogaster
Sequence 2:	NP_592981.1	Gene:	akr1 / 2541757	PomBaseID:	SPAC2F7.10	Length:	642	Species:	Schizosaccharomyces pombe

Alignment Length:	328	Identity:	63/328 - (19%)
Similarity:	104/328 - (31%)	Gaps:	131/328 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 DLVCTRL------VTCRAIDRRNIDGMLIAFQDRLRLPWR----------------GGAKRISPA 100
            :|.|.:|      :.|.|: ..|:.|       :|:.||.                ....::...
pombe   179 NLKCMKLILKEGGIPCTAV-TANLSG-------QLKTPWALASELRVSHLFKQALISNGLKVKET 235

  Fly   101 AVAPA--FIVPLMLGLATLNSKTAIVLMLTLVGFTIWGMELAKRTATRTNFFLS----------- 152
            :..|.  .:||...   ..:.||.|:... |..|.|.|:..         |.:|
pombe   236 SEEPEKWVVVPSKF---QFSQKTFIIFCF-LSSFIITGVFF---------FIMSICPMVISLIIA 287

  Fly   153 --WLVFSVFYM---------IIIFEFQVP-----------------LLELAPEE---------NY 180
              |:.|:..|:         |:.|..:.|                 ||.:.|:.         .:
pombe   288 PLWIYFTFKYITTCIHANIDIVHFYLETPFLAGIFSSIFFWVWCHSLLYIVPKTLPIKPLSSLLF 352

  Fly   181 ALMFFSCAALYCLYSAKALSPLNLVSAQYGTTPKDELPGIAEASSGEEQAEAQTTLQMESVLSLD 245
            .|:.|:|..||             |...:      :.||..:......|       :.|.:..|.
pombe   353 VLISFTCIGLY-------------VRTAF------QNPGYVDKIGAVVQ-------RREEISKLL 391

  Fly   246 DDEVGDMDTAERSGLMHGQPNICEICRKVTPRRAYHCPVCGTCVKRRDHHSYWLNCCIGERNYVW 310
            |.:            :..|.:.|..|.:|.|.|:|||..|..|:.|.|||..|...|:|.||:..
pombe   392 DKD------------LFNQSHYCLKCFQVKPPRSYHCGACKRCINRYDHHCPWTGNCVGARNHRT 444

  Fly   311 YIV 313
            :::
pombe   445 FLL 447

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABPI	NP_608741.1	zf-DHHC	262..399	CDD:279823	20/52 (38%)
akr1	NP_592981.1	ANKYR	4..218	CDD:223738	10/46 (22%)
		ANK	4..121	CDD:238125
		ANK repeat	4..31	CDD:293786
		ANK repeat	34..65	CDD:293786
		ANK repeat	67..98	CDD:293786
		ANK	71..187	CDD:238125	3/7 (43%)
		ANK repeat	100..131	CDD:293786
		ANK repeat	133..164	CDD:293786
		COG5273	311..613	CDD:227598	37/175 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810