DRSC/TRiP Functional Genomics Resources

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Protein Alignment GABPI and Zdhhc2

DIOPT Version :9

Sequence 1:NP_608741.1 Gene:GABPI / 33516 FlyBaseID:FBgn0031495 Length:420 Species:Drosophila melanogaster
Sequence 2:NP_659564.3 Gene:Zdhhc2 / 246326 RGDID:628681 Length:366 Species:Rattus norvegicus


Alignment Length:323 Identity:72/323 - (22%)
Similarity:117/323 - (36%) Gaps:97/323 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    92 GGAKRISPAAV--APAFIVPLMLGLATLNSKTAIVLMLTLVGFTIWGMELAKRTATRTNFFLSWL 154
            ||.:|.....:  .|...:.|:||.    |..|..:.|.:|.....|.::....|..       |
  Rat     7 GGVRRRCRRVLYWIPVVFISLLLGW----SYYAYAIQLCIVSMENIGEQVVCLMAYH-------L 60

  Fly   155 VFSVF---YMIIIFEFQVPLLELAPEENYALMFFSCAALYCLYSAKALSPLNLVSAQYGTTPKDE 216
            :|::|   |...||     .|.:.|.:.:.|.          |:.|                   
  Rat    61 LFAMFVWSYWKTIF-----TLPMNPSKEFHLS----------YAEK------------------- 91

  Fly   217 LPGIAEASSGEEQAEA-QTTLQMESVLSLDDDEVGDMDTAERSGLMHGQPNICEICRKVTPRRAY 280
                 |....|.:.|| |..|:..:         .|:....|:  |.|....|:.||.:.|.|.:
  Rat    92 -----ELLEREPRGEAHQEVLRRAA---------KDLPIYTRT--MSGAIRYCDRCRLIKPDRCH 140

  Fly   281 HCPVCGTCVKRRDHHSYWLNCCIGERNYVWYIVGLALSEIALLLGANLTLTSICHPFMVVRPLGY 345
            ||.||..|:.:.|||..|:|.|:|..||.::::.||.|.:..|             |:....|.|
  Rat   141 HCSVCDKCILKMDHHCPWVNNCVGFSNYKFFLLFLAYSLLYCL-------------FIAATDLQY 192

  Fly   346 PVL-----LPDDCSEVFEGFDLGISFVVACYALLISSYIAFILARQAYLWW---KGSTLHEYK 400
            .:.     |||..::....|   :.|..|.:::.:||...:      :.|.   ..|||..::
  Rat   193 FIRFWTNGLPDTQAKFHIMF---LFFAAAMFSVSLSSLFGY------HCWLVSKNKSTLEAFR 246

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GABPINP_608741.1 zf-DHHC 262..399 CDD:279823 39/144 (27%)
Zdhhc2NP_659564.3 DHHC 19..301 CDD:418707 69/311 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 297..366
Mediates localization to plasma membrane and recycling endosomes. /evidence=ECO:0000250|UniProtKB:P59267 298..366
Non-canonical dileucine endocytic signal. /evidence=ECO:0000250|UniProtKB:P59267 334..335
NPxY-like endocytic signal. /evidence=ECO:0000250|UniProtKB:P59267 357..360
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5273
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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