DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GABPI and ZDHHC17

DIOPT Version :9

Sequence 1:	NP_608741.1	Gene:	GABPI / 33516	FlyBaseID:	FBgn0031495	Length:	420	Species:	Drosophila melanogaster
Sequence 2:	NP_056151.2	Gene:	ZDHHC17 / 23390	HGNCID:	18412	Length:	632	Species:	Homo sapiens

Alignment Length:	313	Identity:	66/313 - (21%)
Similarity:	119/313 - (38%)	Gaps:	99/313 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 FIVPLMLG-LATLNSKTAIVLMLTLVGFTIW-----------------GMELAKRTATRTNFFLS 152
            |:|..::| :|.||..:.::..|...|  :|                 .:.|....||:...:::
Human   311 FLVIWLVGFIADLNIDSWLIKGLMYGG--VWATVQFLSKSFFDHSMHSALPLGIYLATKFWMYVT 373

  Fly   153 WLVFSVFYMIIIFEF-QVPLLELAPEENYALMFFSCAALYCLYSAKALSPLNLVSAQYGTTPKDE 216
            |  |..|:..:.|.| .:|.|     .|...:|::                      :|.:.|.:
Human   374 W--FFWFWNDLNFLFIHLPFL-----ANSVALFYN----------------------FGKSWKSD 409

  Fly   217 LPGIAEASSGEEQAEAQTTLQMESVLSLDDDEVGDMDTAERSGLMHGQPNICEICRKVTPRRAYH 281
             |||.:|:   |:.:.:|.:::.        |.|.:|.:          ..|..|....|.|:.|
Human   410 -PGIIKAT---EEQKKKTIVELA--------ETGSLDLS----------IFCSTCLIRKPVRSKH 452

  Fly   282 CPVCGTCVKRRDHHSYWLNCCIGERNYVWYIVGLALSEIALLLGANLTLTSICHPFMVVRPLGYP 346
            |.||..|:.:.|||..|:..|:|..|: .|.:|...          ..|..||  :|:...:.|.
Human   453 CGVCNRCIAKFDHHCPWVGNCVGAGNH-RYFMGYLF----------FLLFMIC--WMIYGCISYW 504

  Fly   347 VLLPDDCSEVF--EGFDLGISFVVAC----YALLISS-----YIAFILARQAY 388
            .|   .|...:  :||...|:.:..|    :.:.::|     ::|.:|..|.|
Human   505 GL---HCETTYTKDGFWTYITQIATCSPWMFWMFLNSVFHFMWVAVLLMCQMY 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABPI	NP_608741.1	zf-DHHC	262..399	CDD:279823	34/138 (25%)
ZDHHC17	NP_056151.2	Necessary and sufficient for interaction with DNAJC5 and SNAP25. /evidence=ECO:0000250\|UniProtKB:Q80TN5	11..305
		ANK repeat	89..120	CDD:293786
		Ank_2	94..187	CDD:403870
		ANK repeat	122..154	CDD:293786
		ANK repeat	156..187	CDD:293786
		Ank_2	161..255	CDD:403870
		ANK repeat	189..221	CDD:293786
		ANK repeat	224..255	CDD:293786
		Ank_2	229..>286	CDD:423045
		DHHC	438..568	CDD:396215	34/133 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810