DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17219 and HPM1

DIOPT Version :9

Sequence 1:	NP_608740.2	Gene:	CG17219 / 33515	FlyBaseID:	FBgn0031494	Length:	307	Species:	Drosophila melanogaster
Sequence 2:	NP_012156.1	Gene:	HPM1 / 854696	SGDID:	S000001372	Length:	377	Species:	Saccharomyces cerevisiae

Alignment Length:	391	Identity:	97/391 - (24%)
Similarity:	153/391 - (39%)	Gaps:	117/391 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 FNFDVKAESSEDPEAV-KNDIFSKQENSEERESGITKDIDWYNSEKVQPLD-NLISAMDFYELNA 66
            |:|...:...:|.|.| :.:.|  .|:|:|.|:         .:..:.||| :.:|.....:.|.
Yeast     3 FSFGFTSNDFDDDELVAQPETF--VESSKENEN---------TTAYINPLDSDFLSQAGVVQPNV 56

  Fly    67 KEMEVGKMTIKHLVAGFLLEDLKE--------QS----------------HLVNLDLRKSEENHS 107
            :::            |.:||.||:        ||                |.:.|:......|:|
Yeast    57 EDL------------GTILESLKDVRLTFEEFQSPIYRKPLIKRELFDVKHQLMLETDAQSNNNS 109

  Fly   108 ------------DLISGVYEGGAKIWECTEDLLLYLSEKYEDSFWKEKRVLDLGCGCGLLGIYAM 160
                        ||...:||||.|.|||:.||:..|||..:........|:::|||..|...:..
Yeast   110 TELDILLGDTSEDLRKNIYEGGLKSWECSYDLVDLLSENVDRISNDIDAVVEIGCGTALPSEFLF 174

  Fly   161 K---------HGARVDFQDYNKDVLEYITYPNILLNL-------------------DDSLSEDEK 197
            :         .|.:....|||..||..:|.||:::..                   |..::.:|.
Yeast   175 RSALLRNDRSKGLKFVLTDYNASVLRLVTIPNLVITWAKTVLTKEQWYALQKDECEDIPINNEEL 239

  Fly   198 L-------KFLDN------STTLYSGDWSH-FAELSRDV---AKYDLILTSETIYNIANQQKLLD 245
            |       .|.|:      |.||.||.|.. |:.|..:|   ::..|.|:|||||...|...:.:
Yeast   240 LLTSKLLAAFYDDVQSRNISVTLISGSWGRKFSNLIHEVLSGSQKVLSLSSETIYQPDNLPVIAE 304

  Fly   246 TFA---GRLKSDGVILVAAKSHYFGVGGGLEQFSENIRLGNVFQSESV------WQADENLKRGI 301
            |..   ...::|....||||..||||||.:.:|  ...|.:...||.:      ::.:..|||.|
Yeast   305 TILDIHNLPQTDVKTYVAAKDIYFGVGGSITEF--EAYLDDKINSEHLPIHSERFKVNSGLKRSI 367

  Fly   302 L 302
            :
Yeast   368 I 368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17219	NP_608740.2	Methyltransf_18	141..261	CDD:289607	39/167 (23%)
HPM1	NP_012156.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345518
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3897
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	76	1.000	Inparanoid score	I1652
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003521
OrthoInspector	1	1.000	-	-		oto100069
orthoMCL	1	0.900	-	-		OOG6_102864
Panther	1	1.100	-	-	LDO	PTHR14614
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R568
SonicParanoid	1	1.000	-	-		X2887
TreeFam	1	0.960	-	-
	12	11.780