DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17219 and mettl18

DIOPT Version :9

Sequence 1:	NP_608740.2	Gene:	CG17219 / 33515	FlyBaseID:	FBgn0031494	Length:	307	Species:	Drosophila melanogaster
Sequence 2:	NP_001139089.1	Gene:	mettl18 / 796750	ZFINID:	ZDB-GENE-090313-192	Length:	321	Species:	Danio rerio

Alignment Length:	336	Identity:	131/336 - (38%)
Similarity:	176/336 - (52%)	Gaps:	48/336 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 FKFNFDVKAESSEDPEAVKNDIFSKQENSEERESGITKDIDWYNSEKVQPLDNLISAMD----FY 62
            |.||||:             .:.:::.:.:|.:|...||:|...|:....:..|..|::    ..
Zfish     3 FSFNFDI-------------PLVTEETDDKENKSDKAKDVDLKCSKTSTTVLKLKDALEHKPSLN 54

  Fly    63 ELNAKEMEVGK-MTIKHLVAGFLLEDL--------KEQSHLVNLDLRKSEENHSDLISGVYEGGA 118
            .|:..|..|.: :||..|.....|.:.        ||.|..:   |.|:...:|||||||||||.
Zfish    55 PLSKIENWVPETITIGSLPPLLCLNESVFEKTSCEKEDSEEI---LAKTLTQNSDLISGVYEGGL 116

  Fly   119 KIWECTEDLLLYLSEKYEDSFWKEKRVLDLGCGCGLLGIYAMKHGA-RVDFQDYNKDVLEYITYP 182
            ||||||.|||.|:..  |...:..|||||||||.|||||.|:|.|| ||||||||..|:|.:|.|
Zfish   117 KIWECTYDLLEYIDN--EGEVFSGKRVLDLGCGAGLLGILALKRGAIRVDFQDYNSTVIEQLTIP 179

  Fly   183 NILLNLDDSLSEDE-------KLKFLDNSTTL------YSGDWSHFAELSR---DVAKYDLILTS 231
            |:.||.::...:|:       |.|.|::|..|      :||||:.|..|.:   .|.|||:|.||
Zfish   180 NVFLNCEEDDEDDDDDSSPPLKRKSLNSSQELLDHCGFFSGDWNSFLALMQKKASVPKYDIIFTS 244

  Fly   232 ETIYNIANQQKLLDTFAGRLKSDGVILVAAKSHYFGVGGGLEQFSENIRLGNVFQSESVWQADEN 296
            |||||......|...|...|..:|.:.:|.|||||||||||..|...:...|.||.:.:...:|.
Zfish   245 ETIYNTDYYASLHSVFTDLLDRNGNVYLATKSHYFGVGGGLHMFENFVEEKNAFQIKYLKDVEEG 309

  Fly   297 LKRGILQLKFK 307
            |||.::.|.||
Zfish   310 LKRHVVSLSFK 320

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17219	NP_608740.2	Methyltransf_18	141..261	CDD:289607	61/136 (45%)
mettl18	NP_001139089.1	AdoMet_MTases	125..>169	CDD:302624	28/45 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592462
Domainoid	1	1.000	107	1.000	Domainoid score	I6479
eggNOG	1	0.900	-	-		E1_COG3897
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32680
Inparanoid	1	1.050	189	1.000	Inparanoid score	I3885
OMA	1	1.010	-	-		QHG52975
OrthoDB	1	1.010	-	-		D617020at33208
OrthoFinder	1	1.000	-	-		FOG0003521
OrthoInspector	1	1.000	-	-		oto39326
orthoMCL	1	0.900	-	-		OOG6_102864
Panther	1	1.100	-	-	LDO	PTHR14614
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R568
SonicParanoid	1	1.000	-	-		X2887
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800