Protein Alignment Sf3b2 and SF3B2

DIOPT Version :10

• Sequence 1: NP_608739.1
• Gene: Sf3b2 / 33514
• FlyBaseID: FBgn0031493
• Length: 749
• Species: Drosophila melanogaster
• Sequence 2: NP_006833.2
• Gene: SF3B2 / 10992
• HGNCID: 10769
• Length: 895
• Species: Homo sapiens
• Alignment Length: 719
• Identity: 390/719 - (54%)
• Similarity: 486/719 - (67%)
• Gaps: 90/719 - (12%)

  Fly    44 GDASEDAVDAEKTPGELVLPKALEDVLALKDQRAAEFTVDADSQGGSGGATQDGDEADVGEDSEE 108
            ||.:.:..|....|   .:|:|||.:|.||:.|..|.....:.                 |:.|.
Human   254 GDENREMDDPSVGP---KIPQALEKILQLKESRQEEMNSQQEE-----------------EEMET 298

  Fly   109 DADNQVNGSASQKTGKQSKAERNKKKKKRKKQNRKIRHQIEFARQQQLAQAEENEPEAKDSETKA 173
            ||.:.:..|||:.  ::.....:||:|.||::|||
Human   299 DARSSLGQSASET--EEDTVSVSKKEKNRKRRNRK------------------------------ 331

  Fly   174 HGSEDEQVAEKEKKDKR-----KESRSKRRKDRSDEKDTDKKAGEANDENVTIEYVPEKITIADL 233
                      |:||.:|     .||...|.||.:..:.:|..|.:     |.||||.|:..|.:
Human   332 ----------KKKKPQRVRGVSSESSGDREKDSTRSRGSDSPAAD-----VEIEYVTEEPEIYE- 380

  Fly   234 APMYRQFYRVFEIFKL------ENKPKPVEKDKSSHDSESHPRDKKATDKQLEDEDDDGDDDEER 292
             |.:..|.|:||.|||      |.:.:|.:.||.  ::.:.|:.|...::..:.:||..||::|:
Human   381 -PNFIFFKRIFEAFKLTDDVKKEKEKEPEKLDKL--ENSAAPKKKGFEEEHKDSDDDSSDDEQEK 442

  Fly   293 KEDKEKLSKRKLKKLTRLSVAELKQLVSRPDVVEMHDVTARDPKLLVQLKAYRNTVQVPRHWCFK 357
            |.:..||||:||:::.|.:||||||||:||||||||||||:||||||.|||.||:|.||||||||
Human   443 KPEAPKLSKKKLRRMNRFTVAELKQLVARPDVVEMHDVTAQDPKLLVHLKATRNSVPVPRHWCFK 507

  Fly   358 RKYLQGKRGIEKPPFDLPAFIKKTGIMEMRESLQEREDAKTLKAKMRERVRPKMGKIDIDYQKLH 422
            |||||||||||||||:||.|||:|||.||||:|||:|:.||:|:||||:||||||||||||||||
Human   508 RKYLQGKRGIEKPPFELPDFIKRTGIQEMREALQEKEEQKTMKSKMREKVRPKMGKIDIDYQKLH 572

  Fly   423 DAFFKWQTKPRMTIHGDLYYEGKEFETRLKEKKPGDLSEELRIALGMPVGPNSHKIPPPWLIAQQ 487
            ||||||||||::||||||||||||||||||||||||||:||||:||||||||:||:|||||||.|
Human   573 DAFFKWQTKPKLTIHGDLYYEGKEFETRLKEKKPGDLSDELRISLGMPVGPNAHKVPPPWLIAMQ 637

  Fly   488 RYGPPPSYPNLKIPGLNAPIPDGTSFGYHAGGWGKPPVDENGKPLYGDVFGTNILDLDNGVDEAD 552
            |||||||||||||||||:|||:..||||||||||||||||.||||||||||||..:.....:|.:
Human   638 RYGPPPSYPNLKIPGLNSPIPESCSFGYHAGGWGKPPVDETGKPLYGDVFGTNAAEFQTKTEEEE 702

  Fly   553 IERNQWGELESESEESSEEEEEDGEDLGDQQDETGLVTPVE-GLVTPSGLTSVPAGMETPENIEL 616
            |:|..|||||...|||||||||:..| .|:.||||.:||.: ||:||.|.:||||||||||.|||
Human   703 IDRTPWGELEPSDEESSEEEEEEESD-EDKPDETGFITPADSGLITPGGFSSVPAGMETPELIEL 766

  Fly   617 RKKKIEAEMEDNETPVLYQVLPEKRTDRIGASMMGSTHVYDVSGSGANKQPPVRSTTDREGIVEL 681
            ||||||..|:.:|||.|:.|||||||..:|.:||||||:||:|...:.|.|    ..:.:| ||:
Human   767 RKKKIEEAMDGSETPQLFTVLPEKRTATVGGAMMGSTHIYDMSTVMSRKGP----APELQG-VEV 826

  Fly   682 ALDPSELDLDNDAMAQRYEQQMREQQNHLQKEDLSDMLAEHVARQK-SKRKRQQTDPAKTTKKYK 745
            ||.|.||:||..||.|:||:.:||||..::|||.|||:|||.|:|| .|||.|..|....:||||
Human   827 ALAPEELELDPMAMTQKYEEHVREQQAQVEKEDFSDMVAEHAAKQKQKKRKAQPQDSRGGSKKYK 891

  Fly   746 EFKF 749
            ||||
Human   892 EFKF 895

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sf3b2	NP_608739.1	CUS1	166..536	CDD:227509	239/380 (63%)
		DUF382	321..446	CDD:461140	106/124 (85%)
SF3B2	NP_006833.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..24
		SAP	24..57	CDD:460424
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	65..136
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	197..373		43/185 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	400..453		16/54 (30%)
		Required for interaction with PRMT9. /evidence=ECO:0000269|PubMed:25737013	401..550		92/150 (61%)
		CUS1	<442..706	CDD:227509	210/263 (80%)
		DUF382	471..596	CDD:461140	106/124 (85%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	691..757		33/66 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	844..895		29/50 (58%)