DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Sf3b2 and SF3B2

DIOPT Version :9

Sequence 1:NP_001259979.1 Gene:Sf3b2 / 33514 FlyBaseID:FBgn0031493 Length:749 Species:Drosophila melanogaster
Sequence 2:NP_006833.2 Gene:SF3B2 / 10992 HGNCID:10769 Length:895 Species:Homo sapiens


Alignment Length:719 Identity:390/719 - (54%)
Similarity:486/719 - (67%) Gaps:90/719 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    44 GDASEDAVDAEKTPGELVLPKALEDVLALKDQRAAEFTVDADSQGGSGGATQDGDEADVGEDSEE 108
            ||.:.:..|....|   .:|:|||.:|.||:.|..|.....:.                 |:.|.
Human   254 GDENREMDDPSVGP---KIPQALEKILQLKESRQEEMNSQQEE-----------------EEMET 298

  Fly   109 DADNQVNGSASQKTGKQSKAERNKKKKKRKKQNRKIRHQIEFARQQQLAQAEENEPEAKDSETKA 173
            ||.:.:..|||:.  ::.....:||:|.||::|||                              
Human   299 DARSSLGQSASET--EEDTVSVSKKEKNRKRRNRK------------------------------ 331

  Fly   174 HGSEDEQVAEKEKKDKR-----KESRSKRRKDRSDEKDTDKKAGEANDENVTIEYVPEKITIADL 233
                      |:||.:|     .||...|.||.:..:.:|..|.:     |.||||.|:..|.: 
Human   332 ----------KKKKPQRVRGVSSESSGDREKDSTRSRGSDSPAAD-----VEIEYVTEEPEIYE- 380

  Fly   234 APMYRQFYRVFEIFKL------ENKPKPVEKDKSSHDSESHPRDKKATDKQLEDEDDDGDDDEER 292
             |.:..|.|:||.|||      |.:.:|.:.||.  ::.:.|:.|...::..:.:||..||::|:
Human   381 -PNFIFFKRIFEAFKLTDDVKKEKEKEPEKLDKL--ENSAAPKKKGFEEEHKDSDDDSSDDEQEK 442

  Fly   293 KEDKEKLSKRKLKKLTRLSVAELKQLVSRPDVVEMHDVTARDPKLLVQLKAYRNTVQVPRHWCFK 357
            |.:..||||:||:::.|.:||||||||:||||||||||||:||||||.|||.||:|.||||||||
Human   443 KPEAPKLSKKKLRRMNRFTVAELKQLVARPDVVEMHDVTAQDPKLLVHLKATRNSVPVPRHWCFK 507

  Fly   358 RKYLQGKRGIEKPPFDLPAFIKKTGIMEMRESLQEREDAKTLKAKMRERVRPKMGKIDIDYQKLH 422
            |||||||||||||||:||.|||:|||.||||:|||:|:.||:|:||||:||||||||||||||||
Human   508 RKYLQGKRGIEKPPFELPDFIKRTGIQEMREALQEKEEQKTMKSKMREKVRPKMGKIDIDYQKLH 572

  Fly   423 DAFFKWQTKPRMTIHGDLYYEGKEFETRLKEKKPGDLSEELRIALGMPVGPNSHKIPPPWLIAQQ 487
            ||||||||||::||||||||||||||||||||||||||:||||:||||||||:||:|||||||.|
Human   573 DAFFKWQTKPKLTIHGDLYYEGKEFETRLKEKKPGDLSDELRISLGMPVGPNAHKVPPPWLIAMQ 637

  Fly   488 RYGPPPSYPNLKIPGLNAPIPDGTSFGYHAGGWGKPPVDENGKPLYGDVFGTNILDLDNGVDEAD 552
            |||||||||||||||||:|||:..||||||||||||||||.||||||||||||..:.....:|.:
Human   638 RYGPPPSYPNLKIPGLNSPIPESCSFGYHAGGWGKPPVDETGKPLYGDVFGTNAAEFQTKTEEEE 702

  Fly   553 IERNQWGELESESEESSEEEEEDGEDLGDQQDETGLVTPVE-GLVTPSGLTSVPAGMETPENIEL 616
            |:|..|||||...|||||||||:..| .|:.||||.:||.: ||:||.|.:||||||||||.|||
Human   703 IDRTPWGELEPSDEESSEEEEEEESD-EDKPDETGFITPADSGLITPGGFSSVPAGMETPELIEL 766

  Fly   617 RKKKIEAEMEDNETPVLYQVLPEKRTDRIGASMMGSTHVYDVSGSGANKQPPVRSTTDREGIVEL 681
            ||||||..|:.:|||.|:.|||||||..:|.:||||||:||:|...:.|.|    ..:.:| ||:
Human   767 RKKKIEEAMDGSETPQLFTVLPEKRTATVGGAMMGSTHIYDMSTVMSRKGP----APELQG-VEV 826

  Fly   682 ALDPSELDLDNDAMAQRYEQQMREQQNHLQKEDLSDMLAEHVARQK-SKRKRQQTDPAKTTKKYK 745
            ||.|.||:||..||.|:||:.:||||..::|||.|||:|||.|:|| .|||.|..|....:||||
Human   827 ALAPEELELDPMAMTQKYEEHVREQQAQVEKEDFSDMVAEHAAKQKQKKRKAQPQDSRGGSKKYK 891

  Fly   746 EFKF 749
            ||||
Human   892 EFKF 895

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sf3b2NP_001259979.1 CUS1 166..536 CDD:227509 239/380 (63%)
DUF382 320..446 CDD:281964 106/125 (85%)
PSP 451..508 CDD:128850 50/56 (89%)
SF3B2NP_006833.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..24
SAP 24..57 CDD:396567
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 65..136
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 197..373 43/185 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 400..453 16/54 (30%)
Required for interaction with PRMT9. /evidence=ECO:0000269|PubMed:25737013 401..550 92/150 (61%)
CUS1 <442..706 CDD:227509 210/263 (80%)
DUF382 471..596 CDD:397929 106/124 (85%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 691..757 33/66 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 844..895 29/50 (58%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 287 1.000 Domainoid score I1596
eggNOG 1 0.900 - - E1_COG5182
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H6678
Inparanoid 1 1.050 725 1.000 Inparanoid score I623
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG54831
OrthoDB 1 1.010 - - D1275099at2759
OrthoFinder 1 1.000 - - FOG0003115
OrthoInspector 1 1.000 - - oto90100
orthoMCL 1 0.900 - - OOG6_102282
Panther 1 1.100 - - LDO PTHR12785
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1279
SonicParanoid 1 1.000 - - X2980
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1514.870

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