DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3542 and PRP40B

DIOPT Version :9

Sequence 1:	NP_608738.1	Gene:	CG3542 / 33513	FlyBaseID:	FBgn0031492	Length:	806	Species:	Drosophila melanogaster
Sequence 2:	NP_001325767.1	Gene:	PRP40B / 821504	AraportID:	AT3G19670	Length:	992	Species:	Arabidopsis thaliana

Alignment Length:	907	Identity:	235/907 - (25%)
Similarity:	381/907 - (42%)	Gaps:	195/907 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 VPPSVG----NGGAPPGRGIGYTPPGAIV--PQF--PPPGFGAPPPPELAAAFGVMATSTEWTEH 59
            |||.|.    :..|.....|.:|...:.:  |.|  |...|..|.|.:.|.        |:|.||
plant   156 VPPQVTGPSIHSQAQQRASIIHTSAESSIMNPTFEQPKAAFLKPLPSQKAL--------TDWVEH 212

  Fly    60 KAPDGRPYYYNQNTKQSSWEKPEALMTPAELLHNQCPWKEYRSDTGKVYYHNVATKETCWEPPPE 124
            .:.|||.|::|:.||:|:||||..|||..|....:..|||:.|..|:.||:|..||::.|..|.|
plant   213 TSADGRKYFFNKRTKKSTWEKPVELMTLFERADARTDWKEHSSPDGRKYYYNKITKQSTWTMPEE 277

  Fly   125 YVDMK--------AKAKAEEAAAAAKAVAAMTSSSLAGMVPPAALASIL---------------- 165
               ||        |..:...|.....|...:|.|..|....|..|.|..
plant   278 ---MKIVREQAEIASVQGPHAEGIIDASEVLTRSDTASTAAPTGLPSQTSTSEGVEKLTLTSDLK 339

  Fly   166 -PAALP---------------------VAPRLPTPEIHSPLTPSS-------------------- 188
             ||::|                     :.....|..:..|:|.:|
plant   340 QPASVPGSSSPVENVDRVQMSADETSQLCDTSETDGLSVPVTETSAATLVEKDEISVGNSGDSDD 404

  Fly   189 ------NENSSSAMDQAMAATLAAIEVPQQNAKKDDKSESAVVFKDKREAIESFKELLRDRNVPS 247
                  |:.|.|...::....:.:.:|..|..:|....|| ..|.:|.||::.||.||:...|.|
plant   405 MSTKNANQGSGSGPKESQKPMVESEKVESQTEEKQIHQES-FSFNNKLEAVDVFKSLLKSAKVGS 468

  Fly   248 NANWDQCVKIISKDPRYAAFKNLNERKQTFNAYKTQKIKDEREESRLKAKKAKEDLEQFLMSSDK 312
            :..|:|.::.|..|.||.|.:.|.||||.||.:..|..:...||...:.||..||.::.|....:
plant   469 DWTWEQAMREIINDKRYGALRTLGERKQAFNEFLLQTKRAAEEERLARQKKLYEDFKRMLEECVE 533

  Fly   313 MNSQMKYFRCEEVFAGTRTWTAVP-EPDRRDIYEDCIFNLAKREKEEARLLKKRNMKVLGELLES 376
            :....::.:...:|.....:.|:. |.|||:|:||.:..|.::.:.:|...:|||:......|||
plant   534 LTPSTRWSKTVTMFEDDERFKALEREKDRRNIFEDHVSELKEKGRVKALEDRKRNIIEYKRFLES 598

  Fly   377 MTSINHATTWSEAQVMLLDNVAFKNDVTLLGMDKEDALIVFEEHIRTLEKEEDEEREREKKRMKR 441
            ...|...:.|.:.|..|      :.|.....::|.|.|.:|:|::|.||:||:|:::.:|:.:|:
plant   599 CNFIKPNSQWRKVQDRL------EVDERCSRLEKIDQLEIFQEYLRDLEREEEEKKKIQKEELKK 657

  Fly   442 QQRKNRDSFLALLDSLHEEGKLTSMSLW------VELYPIISADLRFSAMLGQSGSTPLDLFKFY 500
            .:||:||.|..|||.....|:||:.::|      |:..|:.||     .....||:||.|||:..
plant   658 VERKHRDEFHGLLDEHIATGELTAKTIWRDYLMKVKDLPVYSA-----IASNSSGATPKDLFEDA 717

  Fly   501 VENLKARFHDEKKIIREILKEKAFVVQAKTSFEDFATVVCEDKRSASLDAGNVKLTYNSLLEKAE 565
            ||:||.|.|:.|..|:::||.:...:.|.::|::|...:.||.....:....:||.::.|||:|:
plant   718 VEDLKKRDHELKSQIKDVLKLRKVNLSAGSTFDEFKVSISEDIGFPLIPDVRLKLVFDDLLERAK 782

  Fly   566 AIEKERMKEEVRRLRKLENEIKNEWLEANVSVAEPYESAKKLVEHLEAFALYEKEIGVEKIWEDF 630
            ..|::..:::.|:..||.:.:::   ..:::.:..:|..|.|||..|..:....|...::.:||:
plant   783 EKEEKEARKQTRQTEKLVDMLRS---FKDITASSSWEELKHLVEGSEKCSTIGDESFRKRCFEDY 844

  Fly   631 V--------------KESEDACSHH----------HSRSRKSKKNKKHKKRVRSVSRSDIENEHI 671
            |              |..||....|          ..|.|:...:..|||........|:...|
plant   845 VSLLKEQSNRIKQNKKVPEDVREEHDKGRDKYGREKDRVRERDSDDHHKKGAAGKYNHDMNEPH- 908

  Fly   672 EVEKSKRRRSKTRSHSL-----TSIGSIESEKLLKKKK-----KRKNKLRGSSCESDVPGIQSPG 726
               ..:||||...||:.     ||:...:::...:..|     |:....||...|::|.|
plant   909 ---GKERRRSGRDSHNRHRERHTSVKENDTDHFKESHKAGGGHKKSRHQRGWVSEAEVEG----- 965

  Fly   727 TQALLQNDSNSHSPAKKKKKEKRAKKDKRHNRHNRSGTPLSPAQSVESSGSRNEELTLSDGE 788
                               ||||.:|                    |.:....:|..|.|||
plant   966 -------------------KEKRRRK--------------------EEAREHTKEEELEDGE 988

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3542	NP_608738.1	PRP40	54..634	CDD:227435	185/672 (28%)
		WW	54..81	CDD:278809	14/26 (54%)
		WW	95..122	CDD:278809	11/26 (42%)
		FF	231..280	CDD:280090	22/48 (46%)
		FF	445..500	CDD:280090	22/60 (37%)
PRP40B	NP_001325767.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	93	1.000	Domainoid score	I2562
eggNOG	1	0.900	-	-		E1_COG5104
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	329	1.000	Inparanoid score	I683
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001909
OrthoInspector	1	1.000	-	-		otm2834
orthoMCL	1	0.900	-	-		OOG6_101966
Panther	1	1.100	-	-	O	PTHR11864
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1440
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.820