Protein Alignment CG3542 and Prpf40a

DIOPT Version :9

• Sequence 1: NP_608738.1
• Gene: CG3542 / 33513
• FlyBaseID: FBgn0031492
• Length: 806
• Species: Drosophila melanogaster
• Sequence 2: XP_006498256.2
• Gene: Prpf40a / 56194
• MGIID: 1860512
• Length: 1016
• Species: Mus musculus
• Alignment Length: 917
• Identity: 375/917 - (40%)
• Similarity: 522/917 - (56%)
• Gaps: 148/917 - (16%)

  Fly     5 PSVGNGGA--------PPGRGIGYTP-PGAIVPQFPPPGFGAPP--------------------- 39
            ||:|:.|.        |.|:.....| |..::||..|| .|.||
Mouse   131 PSMGHPGMHYAPMGMHPMGQRANMPPVPHGMMPQMMPP-MGGPPMGQMPGMMSSVMSGMMMSHMS 194

  Fly    40 --------PPEL----AAAFGVMATSTEWTEHKAPDGRPYYYNQNTKQSSWEKPEALMTPAELLH 92
                    ||.:    .||.......:.|||||:||||.||||..||||:||||:.|.||||.|.
Mouse   195 QASMQPALPPGVNSMDVAAGAASGAKSMWTEHKSPDGRTYYYNTETKQSTWEKPDDLKTPAEQLL 259

  Fly    93 NQCPWKEYRSDTGKVYYHNVATKETCWEPPPEYVDMKAKAKAEEAA------------------- 138
            ::||||||:||:||.||:|..|||:.|..|.|..|::|..||||::
Mouse   260 SKCPWKEYKSDSGKPYYYNSQTKESRWAKPKELEDLEAMIKAEESSKQEECTTASTAPVPTTEIP 324

  Fly   139 ------AAAKAVAAMTSSSLAGMVPPAALASILP----AALPVAPRLPTPEIHSPL-TPSSNEN- 191
                  |||:|.||:.:::.|......|..|..|    .::||||.   ||:.|.: |...|||
Mouse   325 TTMSTMAAAEAAAAVVAAAAAAAAAANANTSTTPTNTVGSVPVAPE---PEVTSIVATAVDNENT 386

  Fly   192 -SSSAMDQAMAATLAAIE-----------------------VPQQNAKKDDKSESAVVFKDKREA 232
             :.|..:||..|...||:                       .|::..::...::....:..|.||
Mouse   387 VTVSTEEQAQLANTTAIQDLSGDISSNTGEEPAKQETVSDFTPKKEEEESQPAKKTYTWNTKEEA 451

  Fly   233 IESFKELLRDRNVPSNANWDQCVKIISKDPRYAAFKNLNERKQTFNAYKTQKIKDEREESRLKAK 297
            .::|||||:::.|||||:|:|.:|:|..||||:|...|:|:||.|||||.|..|:|:||:|.|.|
Mouse   452 KQAFKELLKEKRVPSNASWEQAMKMIINDPRYSALAKLSEKKQAFNAYKVQTEKEEKEEARSKYK 516

  Fly   298 KAKEDLEQFLMSSDKMNSQMKYFRCEEVFAGTRTWTAVPEPDRRDIYEDCIFNLAKREKEEARLL 362
            :|||..::||.:.:||.|..:|.:.|::|.....|.|:.|.||.:||||.:|.|:|:|||:|:.|
Mouse   517 EAKESFQRFLENHEKMTSTTRYKKAEQMFGEMEVWNAISERDRLEIYEDVLFFLSKKEKEQAKQL 581

  Fly   363 KKRNMKVLGELLESMTSINHATTWSEAQVMLLDNVAFKNDVTLLGMDKEDALIVFEEHIRTLEKE 427
            :|||.:.|..:|::|.::.::|||||||..|:||..|..|..|..||||||||.||||||.||||
Mouse   582 RKRNWEALKNILDNMANVTYSTTWSEAQQYLMDNPTFAEDEELQNMDKEDALICFEEHIRALEKE 646

  Fly   428 EDEEREREKKRMKRQQRKNRDSFLALLDSLHEEGKLTSMSLWVELYPIISADLRFSAMLGQS--- 489
            |:||:::...|.:|:|||||:||...||.|||.|:|.|||.|:||||.||:|:||:.||||.
Mouse   647 EEEEKQKTLLRERRRQRKNRESFQIFLDELHEHGQLHSMSSWMELYPTISSDIRFTNMLGQPVFS 711

  Fly   490 -GSTPLDLFKFYVENLKARFHDEKKIIREILKEKAFVVQAKTSFEDFATVVCEDKRSASLDAGNV 553
             |||.|||||||||:||||:|||||||::|||:|.|||:..|:||||..::...|||.:|||||:
Mouse   712 LGSTALDLFKFYVEDLKARYHDEKKIIKDILKDKGFVVEVNTTFEDFVAIISSTKRSTTLDAGNI 776

  Fly   554 KLTYNSLLEKAEAIEKERMKEEVRRLRKLENEIKNEWLEAN--VSVAEPYESAKKLVEHLEAFAL 616
            ||.:|||||||||.|:||.|||.|::::.|:..|:...:|.  :.:...:|..::......||..
Mouse   777 KLAFNSLLEKAEAREREREKEEARKMKRKESAFKSMLKQATPPIELDAVWEDIRERFVKEPAFED 841

  Fly   617 YEKEIGVEKIWEDFVKESEDACSHHHSRSRK-SKKNKKH---KKRVRSVSRSDIENEHIEVEKSK 677
            ...|...::|::||:...|..|.||||:::| |||:|||   :.|.||.|.||.::.|     ||
Mouse   842 ITLESERKRIFKDFMHVLEHECQHHHSKNKKHSKKSKKHHRKRSRSRSGSESDDDDSH-----SK 901

  Fly   678 RRRSKTRSHSLTS-IGSIESEKLLKKKKKRKNKLRGSSCESDVPGIQSPGTQALLQNDSNSHSPA 741
            ::|.::.|||.:. ..|.|||:..||.||.|.|.:....:||.|               .|.:..
Mouse   902 KKRQRSESHSASERSSSAESERSYKKSKKHKKKSKKRRHKSDSP---------------ESDTER 951

  Fly   742 KKKKKEKRAKKDKRHNRHNRSGTPLSPAQSV-------ESSGSRNEELTLSDGELESKRAALLAQ 799
            :|.||||....:|..:|........||.:..       ::|||.     ||:||||.:|..||
Mouse   952 EKDKKEKDRDSEKDRSRQRSESKHKSPKKKTGKDSGNWDTSGSE-----LSEGELEKRRRTLL-- 1009

  Fly   800 LSEQLDE 806
              ||||:
Mouse  1010 --EQLDD 1014

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3542	NP_608738.1	PRP40	54..634	CDD:227435	291/640 (45%)
		WW	54..81	CDD:278809	19/26 (73%)
		WW	95..122	CDD:278809	17/26 (65%)
		FF	231..280	CDD:280090	27/48 (56%)
		FF	445..500	CDD:280090	37/58 (64%)
Prpf40a	XP_006498256.2	PRP40	223..>740	CDD:227435	243/519 (47%)
		FF	803..857	CDD:128718	10/53 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835508
Domainoid	1	1.000	85	1.000	Domainoid score	I8187
eggNOG	1	0.900	-	-		E1_COG5104
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	614	1.000	Inparanoid score	I899
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55014
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001909
OrthoInspector	1	1.000	-	-		otm43969
orthoMCL	1	0.900	-	-		OOG6_101966
Panther	1	1.100	-	-	LDO	PTHR11864
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2925
SonicParanoid	1	1.000	-	-		X1440
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.790