DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3542 and Prpf40b

DIOPT Version :9

Sequence 1:	NP_608738.1	Gene:	CG3542 / 33513	FlyBaseID:	FBgn0031492	Length:	806	Species:	Drosophila melanogaster
Sequence 2:	XP_011243999.1	Gene:	Prpf40b / 54614	MGIID:	1925583	Length:	903	Species:	Mus musculus

Alignment Length:	899	Identity:	359/899 - (39%)
Similarity:	508/899 - (56%)	Gaps:	137/899 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 VPPSVGNGGAPP----GRGIGYTPPGAIVPQFPPPGFGAPPP--------PEL------------ 43
            :||.....|.||    ...|...|||.:.|..||  .|||||        |.:
Mouse    41 LPPPFPPMGLPPMSQRPPAIPPMPPGILPPMLPP--MGAPPPLTQIPGMVPPMMPGMLMPAVPVT 103

  Fly    44 -AAAFGVMATSTE----------WTEHKAPDGRPYYYNQNTKQSSWEKPEALMTPAELLHNQCPW 97
             |.|.|....|:.          |:||.|||||.||||.:.|||.||||..|.:.||||.:||||
Mouse   104 AATAPGADTASSAVAGTGPPRALWSEHVAPDGRIYYYNADDKQSVWEKPSVLKSKAELLLSQCPW 168

  Fly    98 KEYRSDTGKVYYHNVATKETCWEPPPEYVDMKAKAKAEEAAAAAKAVAAMTSSSLAGMVPPAALA 162
            |||:|||||.||:|..::|:.|..|.:..|::|..|.|.|       ....:..|..:.|.....
Mouse   169 KEYKSDTGKPYYYNNQSQESRWTRPKDLDDLEALVKQESA-------GKQQTQQLQTLQPQPPQP 226

  Fly   163 SILPAALPVAPRLPTPEIHSPLTPSSNEN-----SSSAMDQAM-------AATLAAIEVPQQNAK 215
            ...|..:|..| :|.|.......|..:|:     ::..::|..       :::......||:..:
Mouse   227 QPDPPPIPPGP-IPVPMALLEPEPGRSEDCDVLEAAQPLEQGFLQREEGPSSSTGQHRQPQEEEE 290

  Fly   216 -KDDKSESAVVFKDKREAIESFKELLRDRNVPSNANWDQCVKIISKDPRYAAFKNLNERKQTFNA 279
             |.:...|.:.:.::.:|.::|||||||:.|||||:|:|.:|::..||||:|...|:|:||.|||
Mouse   291 AKPEPERSGLSWSNREKAKQAFKELLRDKAVPSNASWEQAMKMVVTDPRYSALPKLSEKKQAFNA 355

  Fly   280 YKTQKIKDEREESRLKAKKAKEDLEQFLMSSDKMNSQMKYFRCEEVFAGTRTWTAVPEPDRRDIY 344
            ||.|:.|:|:||:||:||:||:.|:.||...::|.|..:|.|.|:.|.....|..|||.:|:::|
Mouse   356 YKAQREKEEKEEARLRAKEAKQTLQHFLEQHERMTSTTRYRRAEQTFGDLEVWAVVPERERKEVY 420

  Fly   345 EDCIFNLAKREKEEARLLKKRNMKVLGELLESMTSINHATTWSEAQVMLLDNVAFKNDVTLLGMD 409
            :|.:|.|||:|||:|:.|::||::.|..:|:.|:|:|..||||:||..|:||.:|..|..|..||
Mouse   421 DDVLFFLAKKEKEQAKQLRRRNIQALKSILDGMSSVNFQTTWSQAQQYLMDNPSFAQDQQLQNMD 485

  Fly   410 KEDALIVFEEHIRTLEKEEDEEREREKKRMKRQQRKNRDSFLALLDSLHEEGKLTSMSLWVELYP 474
            ||||||.||||||.||:||:|||||.:.|.:|||||||::|.:.||.|||.|:|.|||.|:||||
Mouse   486 KEDALICFEEHIRALEREEEEERERARLRERRQQRKNREAFQSFLDELHETGQLHSMSTWMELYP 550

  Fly   475 IISADLRFSAMLGQSGSTPLDLFKFYVENLKARFHDEKKIIREILKEKAFVVQAKTSFEDFATVV 539
            .:|.|:||:.||||.|||||||||||||.||||||||||||::|||::.|.|:..|:|||||.|:
Mouse   551 AVSTDVRFANMLGQPGSTPLDLFKFYVEELKARFHDEKKIIKDILKDRGFCVEVNTAFEDFAHVI 615

  Fly   540 CEDKRSASLDAGNVKLTYNSLLEKAEAIEKERMKEEVRRLRKLENEIKNEWLEANVSVAEPYESA 604
            ..|||:|:|||||:|||:|||||||||.|:||.|||.||:|:.|...:: .|...|...|...:.
Mouse   616 SFDKRAAALDAGNIKLTFNSLLEKAEAREREREKEEARRMRRREAAFRS-MLRQAVPALELGTAW 679

  Fly   605 KKLVEHLEAFALYEKEIGVE----KIWEDFVKESEDA-CSHHHSRSRK-SKKNKK-HKKRVR--S 660
            :::.|.....:.:| :|.:|    :::.:|::..|.. |.|.|::.|| .:|.|| |:||..  |
Mouse   680 EEVRERFVCDSAFE-QITLESERIRLFREFLQVLEQTECQHLHTKGRKHGRKGKKHHRKRSHSPS 743

  Fly   661 VSRSDIENEHIE-----VEKSKRRR---SKTRSHSLTSIGSIESEKLLKKKKKRKNKLRGSSCES 717
            |||...|::..|     :...||||   |::.|...:|:.|:||               |.:.
Mouse   744 VSRQGSESDEEELPPPSLRPPKRRRRNPSESGSEPSSSLDSVES---------------GGAA-- 791

  Fly   718 DVPGIQSPGTQALLQNDSNSHSPAKKKKKEKRAKKDKRHNRHNRSGTPLSPAQSVESSGSRNE-- 780
             :.|..||.:..||.:|   |...|.||.:|:.||     |.::|.:|.|.....:.:|..:|
Mouse   792 -LGGPGSPSSHLLLGSD---HGLRKTKKPKKKTKK-----RRHKSTSPDSETDPEDKAGKESEDR 847

  Fly   781 --------------------------------ELTLSDGELESKRAALLAQLSE 802
                                            |..||:||||.:|..||.||.:
Mouse   848 EQEQDREPRQAELPNRSPGFGIKKEKTGWDTSESELSEGELERRRRTLLQQLDD 901

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3542	NP_608738.1	PRP40	54..634	CDD:227435	277/606 (46%)
		WW	54..81	CDD:278809	17/36 (47%)
		WW	95..122	CDD:278809	16/26 (62%)
		FF	231..280	CDD:280090	27/48 (56%)
		FF	445..500	CDD:280090	36/54 (67%)
Prpf40b	XP_011243999.1	PRP40	118..>610	CDD:227435	233/499 (47%)
Prpf40b	XP_011243999.1	FF	662..710	CDD:128718	8/49 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835509
Domainoid	1	1.000	180	1.000	Domainoid score	I3510
eggNOG	1	0.900	-	-		E1_COG5104
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H81828
Inparanoid	1	1.050	614	1.000	Inparanoid score	I899
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55014
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001909
OrthoInspector	1	1.000	-	-		otm43969
orthoMCL	1	0.900	-	-		OOG6_101966
Panther	1	1.100	-	-	O	PTHR11864
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2925
SonicParanoid	1	1.000	-	-		X1440
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.790