DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3542 and WAC

DIOPT Version :9

Sequence 1:	NP_608738.1	Gene:	CG3542 / 33513	FlyBaseID:	FBgn0031492	Length:	806	Species:	Drosophila melanogaster
Sequence 2:	NP_057712.2	Gene:	WAC / 51322	HGNCID:	17327	Length:	647	Species:	Homo sapiens

Alignment Length:	197	Identity:	45/197 - (22%)
Similarity:	74/197 - (37%)	Gaps:	45/197 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 TSTEWTEHKAPDGRPYYYNQNTKQSSWEKPEALMTPAELLHNQCPWKEYRSDTGKVYYHNVATKE 116
            ::.:|:||.:..|:.||||..|:.|.||||:      |.|..:...||             |.|.
Human   131 SADDWSEHISSSGKKYYYNCRTEVSQWEKPK------EWLEREQRQKE-------------ANKM 176

  Fly   117 TCWEPPPEYVDMKAKAKAEEAAAAAKAVAAMTSSSLAGMVPPAAL-------------------A 162
            .....|.:....:...:|...:..|..:....||..:.::|...|                   :
Human   177 AVNSFPKDRDYRREVMQATATSGFASGMEDKHSSDASSLLPQNILSQTSRHNDRDYRLPRAETHS 241

  Fly   163 SILPAALPVAP-----RLPTPEIHSPLTPSSNENSSSAMDQAMAATLAAIEVPQQN--AKKDDKS 220
            |..|...|:.|     ..|:....||.|..|:.....:.|...|:||:.:..|..:  |:|.::.
Human   242 SSTPVQHPIKPVVHPTATPSTVPSSPFTLQSDHQPKKSFDANGASTLSKLPTPTSSVPAQKTERK 306

  Fly   221 ES 222
            ||
Human   307 ES 308

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3542	NP_608738.1	PRP40	54..634	CDD:227435	45/195 (23%)
		WW	54..81	CDD:278809	12/26 (46%)
		WW	95..122	CDD:278809	4/26 (15%)
		FF	231..280	CDD:280090
		FF	445..500	CDD:280090
WAC	NP_057712.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..138		1/6 (17%)
		WW	133..160	CDD:278809	12/26 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	168..353		29/154 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	428..549
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5104
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900