Protein Alignment Prp40 and Prpf40b

DIOPT Version :10

• Sequence 1: NP_608738.1
• Gene: Prp40 / 33513
• FlyBaseID: FBgn0031492
• Length: 806
• Species: Drosophila melanogaster
• Sequence 2: XP_006257426.1
• Gene: Prpf40b / 363000
• RGDID: 1565411
• Length: 934
• Species: Rattus norvegicus
• Alignment Length: 899
• Identity: 362/899 - (40%)
• Similarity: 507/899 - (56%)
• Gaps: 139/899 - (15%)

  Fly     3 VPPSVGNGGAPP----GRGIGYTPPGAIVPQFPPPGFGAPPP--------PEL------------ 43
            :||.....|.||    ...|...|||.:.|..||  .|||||        |.:
  Rat    74 LPPPFPPMGLPPMSQRPPAIPPMPPGILPPMLPP--MGAPPPLTQIPGMVPPMMPGMLMPAVPVT 136

  Fly    44 -AAAFGVMATSTE----------WTEHKAPDGRPYYYNQNTKQSSWEKPEALMTPAELLHNQCPW 97
             |.|.|....|:.          |:||.|||||.||||.:.|||.||||.||.:.||||.:||||
  Rat   137 AATAPGADTASSAVPGTGPPRALWSEHVAPDGRIYYYNADDKQSVWEKPSALKSKAELLLSQCPW 201

  Fly    98 KEYRSDTGKVYYHNVATKETCWEPPPEYVDMKAKAKAEEAAAAAKAVAAMTSSSLAGMVPPAALA 162
            |||:|||||.||:|..::|:.|..|.:..|::|..|.|.|...    ......:|....|.....
  Rat   202 KEYKSDTGKPYYYNNQSQESRWTRPKDLDDLEALVKQESAGKQ----QTQQLQTLQPQPPQPDPP 262

  Fly   163 SILPAALPVAPRLPTPEIHSPLTPSSNEN-----SSSAMDQAM-------AATLAAIEVPQQNAK 215
            .|.|..:||...|..||      |..:|:     ::..::|..       :::.....:||:..:
  Rat   263 PIPPGPIPVPMALLEPE------PGRSEDCDVLEAAQPLEQGFLQREEGPSSSTGQHRLPQEEEE 321

  Fly   216 -KDDKSESAVVFKDKREAIESFKELLRDRNVPSNANWDQCVKIISKDPRYAAFKNLNERKQTFNA 279
             |.:...|.:.:.::.:|.::|||||||:.|||||:|:|.:|::..||||:|...|:|:||.|||
  Rat   322 AKPEPERSGLSWSNREKAKQAFKELLRDKAVPSNASWEQAMKMVVTDPRYSALPKLSEKKQAFNA 386

  Fly   280 YKTQKIKDEREESRLKAKKAKEDLEQFLMSSDKMNSQMKYFRCEEVFAGTRTWTAVPEPDRRDIY 344
            ||.|:.|:|:||:||:||:||:.|:.||...::|.|..:|.|.|:.|.....|..|||.||:::|
  Rat   387 YKAQREKEEKEEARLRAKEAKQTLQHFLEQHERMTSTTRYRRAEQTFGDLEVWAVVPERDRKEVY 451

  Fly   345 EDCIFNLAKREKEEARLLKKRNMKVLGELLESMTSINHATTWSEAQVMLLDNVAFKNDVTLLGMD 409
            :|.:|.|||:|||:|:.|::||::.|..:|:.|:|:|..||||:||..|:||.:|..|..|..||
  Rat   452 DDVLFFLAKKEKEQAKQLRRRNIQALKSILDGMSSVNFQTTWSQAQQYLMDNPSFAQDQQLQNMD 516

  Fly   410 KEDALIVFEEHIRTLEKEEDEEREREKKRMKRQQRKNRDSFLALLDSLHEEGKLTSMSLWVELYP 474
            ||||||.||||||.||:||:|||||.:.|.:|||||||::|...||.|||.|:|.|||.|:||||
  Rat   517 KEDALICFEEHIRALEREEEEERERARLRERRQQRKNREAFQTFLDELHETGQLHSMSTWMELYP 581

  Fly   475 IISADLRFSAMLGQSGSTPLDLFKFYVENLKARFHDEKKIIREILKEKAFVVQAKTSFEDFATVV 539
            .:|.|:||:.||||.|||||||||||||.||||||||||||::|||::.|.|:..|:|||||.|:
  Rat   582 AVSTDVRFANMLGQPGSTPLDLFKFYVEELKARFHDEKKIIKDILKDRGFCVEVNTAFEDFAHVI 646

  Fly   540 CEDKRSASLDAGNVKLTYNSLLEKAEAIEKERMKEEVRRLRKLENEIKNEWLEANVSVAEPYESA 604
            ..|||:|:|||||:|||:|||||||||.|:||.|||.||:|:.|...:: .|...|...|...:.
  Rat   647 SFDKRAAALDAGNIKLTFNSLLEKAEAREREREKEEARRMRRREAAFRS-MLRQAVPALELGTAW 710

  Fly   605 KKLVEHLEAFALYEKEIGVE----KIWEDFVKESEDA-CSHHHSRSRK--SKKNKKHKKR--VRS 660
            :::.|.....:.:| :|.:|    :::.:|::..|.. |.|.|::.||  .|..|.|:||  ..|
  Rat   711 EEVRERFVCDSAFE-QITLESERIRLFREFLQVLEQTECQHLHTKGRKHGRKGRKHHRKRSHTPS 774

  Fly   661 VSRSDIENEHIE-----VEKSKRRR---SKTRSHSLTSIGSIESEKLLKKKKKRKNKLRGSSCES 717
            |||...|::..|     :...||||   |::.|...:|:.|:||               |.:.
  Rat   775 VSRQGSESDEEELPPPSLRPPKRRRRNPSESGSEPSSSLDSVES---------------GGAA-- 822

  Fly   718 DVPGIQSPGTQALLQNDSNSHSPAKKKKKEKRAKKDKRHNRHNRSGTPLSPAQSVESSGSRNE-- 780
             :.|..||.:..||.:|   |...|.||.:|:.||     |.::|.:|.|.....:.:|..:|
  Rat   823 -LGGPGSPSSHLLLGSD---HGLRKTKKPKKKTKK-----RRHKSTSPDSETDPEDKAGKESEDR 878

  Fly   781 --------------------------------ELTLSDGELESKRAALLAQLSE 802
                                            |..||:||||.:|..||.||.:
  Rat   879 EQEQDREPRQAELPNRSPGFGIKKEKTGWDTSESELSEGELERRRRTLLQQLDD 932

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prp40	NP_608738.1	PRP40	54..634	CDD:227435	281/606 (46%)
Prpf40b	XP_006257426.1	PRP40	146..>641	CDD:227435	238/504 (47%)
		FF	693..741	CDD:128718	8/49 (16%)