Protein Alignment Prp40 and prpf40a

DIOPT Version :10

• Sequence 1: NP_608738.1
• Gene: Prp40 / 33513
• FlyBaseID: FBgn0031492
• Length: 806
• Species: Drosophila melanogaster
• Sequence 2: NP_938170.1
• Gene: prpf40a / 321555
• ZFINID: ZDB-GENE-030131-274
• Length: 851
• Species: Danio rerio
• Alignment Length: 884
• Identity: 372/884 - (42%)
• Similarity: 512/884 - (57%)
• Gaps: 127/884 - (14%)

  Fly     1 MNVPPSVGNGGAPPGRGIGYTPPGAIVPQFPPPGFGAPP-----------------PPELAAAF- 47
            |.:||.   |..||  .:...|||.:.|..||  .||||                 ||.|.||.
Zfish    14 MGMPPM---GQRPP--SLAPMPPGIMPPMMPP--MGAPPIGQMPAMMPPMMPGMMMPPRLPAASI 71

  Fly    48 ------GV--------------MATSTE------------WTEHKAPDGRPYYYNQNTKQSSWEK 80
                  ||              ..||||            |||||:.||:.||||..||||:|||
Zfish    72 QPTGPPGVSPVEAAAPAAPGTTSTTSTESSPDEQPKKKSVWTEHKSLDGKIYYYNTETKQSTWEK 136

  Fly    81 PEALMTPAELLHNQCPWKEYRSDTGKVYYHNVATKETCWEPPPEYVDMKAKAKAEE-------AA 138
            |:.|.:|||.:.::||||||:|||||.||:|..|||:.|..|.|..|::|..||||       |.
Zfish   137 PDELKSPAEQMLSKCPWKEYKSDTGKPYYYNSQTKESRWTKPKELEDLEAMIKAEENGTADVVAP 201

  Fly   139 AAAKAVAAMTSSSLAGMVPPAALASIL--------PAALPVAPRLPTPEIHSPLTPSSNENSSSA 195
            ....|:.|...||:. :.|.|...:.:        |:.:|.    ...|:.|.:..:|.|.:.|.
Zfish   202 GTTPALTAQNESSVT-VAPVAETEATMATGTIEEQPSHVPA----QVAEVSSDVAVNSTEETPSV 261

  Fly   196 MDQAMAATLAAIEVPQQNAKKDDKSESA-VVFK--DKREAIESFKELLRDRNVPSNANWDQCVKI 257
            ..|           |..:..|:::.|.. .|:|  .|.||.::|||||:::.|.|||:|:|.:|:
Zfish   262 ETQ-----------PSNDVSKEERPELVKKVYKWNTKEEAKQAFKELLKEKGVSSNASWEQAMKL 315

  Fly   258 ISKDPRYAAFKNLNERKQTFNAYKTQKIKDEREESRLKAKKAKEDLEQFLMSSDKMNSQMKYFRC 322
            |..||||:|...|:|:||.|||||.|..|:|:||:|:|.|::||..::||.:.:||.|..:|.:.
Zfish   316 IINDPRYSALPKLSEKKQAFNAYKVQTEKEEKEEARIKYKESKETFQRFLENHEKMTSTTRYKKA 380

  Fly   323 EEVFAGTRTWTAVPEPDRRDIYEDCIFNLAKREKEEARLLKKRNMKVLGELLESMTSINHATTWS 387
            |::|.....|:.|||.||.:||||.:|.|||:|||:|:.|:|||.:.|..:|::|.::.:.||||
Zfish   381 EQMFGDQEVWSCVPERDRLEIYEDVLFYLAKKEKEQAKQLRKRNWEALKNILDNMANVTYRTTWS 445

  Fly   388 EAQVMLLDNVAFKNDVTLLGMDKEDALIVFEEHIRTLEKEEDEEREREKKRMKRQQRKNRDSFLA 452
            |||..||||..|..|..|..||||||||.||||||.|||||::|:::...|.:|:|||||:||..
Zfish   446 EAQQYLLDNPTFAEDEELQNMDKEDALICFEEHIRALEKEEEDEKQKTLLRERRRQRKNRESFQK 510

  Fly   453 LLDSLHEEGKLTSMSLWVELYPIISADLRFSAMLGQSGSTPLDLFKFYVENLKARFHDEKKIIRE 517
            .||.||:.|:|.|||.|:|:||.||||:|||.||||.|||||||||||||:||||:||||:||::
Zfish   511 FLDELHDHGQLHSMSAWMEMYPTISADIRFSNMLGQPGSTPLDLFKFYVEDLKARYHDEKRIIKD 575

  Fly   518 ILKEKAFVVQAKTSFEDFATVVCEDKRSASLDAGNVKLTYNSLLEKAEAIEKERMKEEVRRLRKL 582
            |||:|.|:|:..|.||||.:|:..|||:.:|||||:||.:|||||||||.|:||.|||.|::::.
Zfish   576 ILKDKGFLVEINTGFEDFGSVISSDKRATTLDAGNIKLAFNSLLEKAEAREREREKEEARKMKRK 640

  Fly   583 ENEIKNEWLEANVSVAEP---YESAKKLVEHLEAFALYEKEIGVEKIWEDFVKESEDACSHHHSR 644
            |...|:...:|...: ||   :|..::......||.....|...::|::||:...|..|.||||:
Zfish   641 EAAFKSMLKQATPPL-EPEATWEGVRERFLKEPAFEDITLESERKRIFKDFMHVLEHECQHHHSK 704

  Fly   645 SRK-SKKNKKHKKRVRSVSRSDIENEHIEVEKSKRRRSKTRSHSLTSIGSIESEKLLKKKKKRKN 708
            ::| |||:|||.:: ||.|||..|:|..|....|::||.::|.|..| .|.|||:..||.||.|.
Zfish   705 TKKHSKKSKKHHRK-RSRSRSGSESEEDEYHTKKKKRSTSKSPSEHS-SSGESERSYKKSKKHKK 767

  Fly   709 KLRGSSCESDVPGIQSPGTQALLQNDSNSHSPAKKKKKEKRAKKDKRHNRHNRSGTPLSPAQSV- 772
            |.:....:|..|             :|......|.::|:|..:.||...:........||.:..
Zfish   768 KGKKRRHKSGSP-------------ESEGERERKGREKDKDKENDKSRAKLRGESKQKSPKRKSA 819

  Fly   773 ------ESSGSRNEELTLSDGELESKRAALLAQLSEQLD 805
                  ::|||.     ||:||||.:|..||    ||||
Zfish   820 KEEGGWDTSGSE-----LSEGELEKRRRTLL----EQLD 849

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prp40	NP_608738.1	PRP40	54..634	CDD:227435	284/612 (46%)
prpf40a	NP_938170.1	PRP40	110..>575	CDD:227435	232/480 (48%)
		FF	638..692	CDD:128718	12/54 (22%)