DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3542 and PRPF40B

DIOPT Version :9

Sequence 1:	NP_608738.1	Gene:	CG3542 / 33513	FlyBaseID:	FBgn0031492	Length:	806	Species:	Drosophila melanogaster
Sequence 2:	XP_011536437.1	Gene:	PRPF40B / 25766	HGNCID:	25031	Length:	966	Species:	Homo sapiens

Alignment Length:	859	Identity:	344/859 - (40%)
Similarity:	487/859 - (56%)	Gaps:	114/859 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PPSVGNGGAPPGRGIGYTPPGAIVPQFPPPGFGAPPPPELAAAFGVMATSTE------------- 55
            ||::.:.||        ||..:....:||.... .|.|..:...|...|.|:
Human   106 PPTLSSDGA--------TPHESETTSYPPHATW-HPAPNASTNGGATTTHTDTRNGTSDDARNAD 161

  Fly    56 --------------------WTEHKAPDGRPYYYNQNTKQSSWEKPEALMTPAELLHNQCPWKEY 100
                                |:||.|||||.||||.:.|||.||||..|.:.||||.:|||||||
Human   162 ASGACHRSAAVAGTGPPRALWSEHVAPDGRIYYYNADDKQSVWEKPSVLKSKAELLLSQCPWKEY 226

  Fly   101 RSDTGKVYYHNVATKETCWEPPPEYVDMKAKAKAEEAAAAAKAVAAMTSSSLAGMVPPAALAS-- 163
            :|||||.||:|..:||:.|..|.:..|::...|.|.|....:.:.......     ||.....
Human   227 KSDTGKPYYYNNQSKESRWTRPKDLDDLEVLVKQEAAGKQQQQLPQTLQPQ-----PPQPQPDPP 286

  Fly   164 -ILPAALPVAPRLPTPEIHSPLTPSSNEN-----SSSAMDQAMAATL------AAIEVPQQNAK- 215
             :.|...||...|..||      |..:|:     ::..::|.....|      :....|||..:
Human   287 PVPPGPTPVPTGLLEPE------PGGSEDCDVLEATQPLEQGFLQQLEEGPSSSGQHQPQQEEEE 345

  Fly   216 -KDDKSESAVVFKDKREAIESFKELLRDRNVPSNANWDQCVKIISKDPRYAAFKNLNERKQTFNA 279
             |.:...|.:.:.::.:|.::|||||||:.|||||:|:|.:|::..||||:|...|:|:||.|||
Human   346 SKPEPERSGLSWSNREKAKQAFKELLRDKAVPSNASWEQAMKMVVTDPRYSALPKLSEKKQAFNA 410

  Fly   280 YKTQKIKDEREESRLKAKKAKEDLEQFLMSSDKMNSQMKYFRCEEVFAGTRTWTAVPEPDRRDIY 344
            ||.|:.|:|:||:||:||:||:.|:.||...::|.|..:|.|.|:.|.....|..|||.||:::|
Human   411 YKAQREKEEKEEARLRAKEAKQTLQHFLEQHERMTSTTRYRRAEQTFGELEVWAVVPERDRKEVY 475

  Fly   345 EDCIFNLAKREKEEARLLKKRNMKVLGELLESMTSINHATTWSEAQVMLLDNVAFKNDVTLLGMD 409
            :|.:|.|||:|||:|:.|::||::.|..:|:.|:|:|..||||:||..|:||.:|..|..|..||
Human   476 DDVLFFLAKKEKEQAKQLRRRNIQALKSILDGMSSVNFQTTWSQAQQYLMDNPSFAQDHQLQNMD 540

  Fly   410 KEDALIVFEEHIRTLEKEEDEEREREKKRMKRQQRKNRDSFLALLDSLHEEGKLTSMSLWVELYP 474
            ||||||.||||||.||:||:|||||.:.|.:|||||||::|...||.|||.|:|.|||.|:||||
Human   541 KEDALICFEEHIRALEREEEEERERARLRERRQQRKNREAFQTFLDELHETGQLHSMSTWMELYP 605

  Fly   475 IISADLRFSAMLGQSGSTPLDLFKFYVENLKARFHDEKKIIREILKEKAFVVQAKTSFEDFATVV 539
            .:|.|:||:.||||.|||||||||||||.||||||||||||::|||::.|.|:..|:|||||.|:
Human   606 AVSTDVRFANMLGQPGSTPLDLFKFYVEELKARFHDEKKIIKDILKDRGFCVEVNTAFEDFAHVI 670

  Fly   540 CEDKRSASLDAGNVKLTYNSLLEKAEAIEKERMKEEVRRLRKLENEIKNEWLEANVSVAEPYESA 604
            ..|||:|:|||||:|||:|||||||||.|:||.|||.||:|:.|...:: .|...|...|...:.
Human   671 SFDKRAAALDAGNIKLTFNSLLEKAEAREREREKEEARRMRRREAAFRS-MLRQAVPALELGTAW 734

  Fly   605 KKLVEHLEAFALYEKEIGVE----KIWEDFVKESEDA-CSHHHSRSRK-SKKNKK-HKKRVRSVS 662
            :::.|.....:.:| :|.:|    :::.:|::..|.. |.|.|::.|| .:|.|| |.||..|.|
Human   735 EEVRERFVCDSAFE-QITLESERIRLFREFLQVLEQTECQHLHTKGRKHGRKGKKHHHKRSHSPS 798

  Fly   663 RSDIENEHI---EVEKSKRRR---SKTRSHSLTSIGSIESEKLLKKKKKRKNKLRGSSCESDVPG 721
            .|:.|.|.:   .:...||||   |::.|...:|:.|:||               |.:.   :.|
Human   799 GSESEEEELPPPSLRPPKRRRRNPSESGSEPSSSLDSVES---------------GGAA---LGG 845

  Fly   722 IQSPGTQALLQNDSNSHSPAKKKKKEKRAKKDKRHNRHNRSGTPLSPAQSVESSGSRNEELTLSD 786
            ..||.:..|    ...|...|.||.:|:.||     |.::|.:|.|.....|.:|..::|   .:
Human   846 RGSPSSHLL----GADHGLRKAKKPKKKTKK-----RRHKSNSPESETDPEEKAGKESDE---KE 898

  Fly   787 GELESKRAALLAQL 800
            .|.:..|....|:|
Human   899 QEQDKDRELQQAEL 912

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3542	NP_608738.1	PRP40	54..634	CDD:227435	282/632 (45%)
		WW	54..81	CDD:278809	18/59 (31%)
		WW	95..122	CDD:278809	17/26 (65%)
		FF	231..280	CDD:280090	27/48 (56%)
		FF	445..500	CDD:280090	36/54 (67%)
PRPF40B	XP_011536437.1	PRP40	173..>665	CDD:227435	237/502 (47%)
		WW	182..207	CDD:278809	17/24 (71%)
		WW	221..250	CDD:238122	18/28 (64%)
		FF	362..411	CDD:280090	27/48 (56%)
		P-loop_NTPase	484..>542	CDD:304359	27/57 (47%)
		FF	576..631	CDD:280090	36/54 (67%)
		FF	717..765	CDD:128718	8/49 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145441
Domainoid	1	1.000	181	1.000	Domainoid score	I3496
eggNOG	1	0.900	-	-		E1_COG5104
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H81828
Inparanoid	1	1.050	613	1.000	Inparanoid score	I914
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55014
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001909
OrthoInspector	1	1.000	-	-		otm41921
orthoMCL	1	0.900	-	-		OOG6_101966
Panther	1	1.100	-	-	O	PTHR11864
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2925
SonicParanoid	1	1.000	-	-		X1440
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.790