DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3542 and prp-40

DIOPT Version :9

Sequence 1:	NP_608738.1	Gene:	CG3542 / 33513	FlyBaseID:	FBgn0031492	Length:	806	Species:	Drosophila melanogaster
Sequence 2:	NP_001255005.1	Gene:	prp-40 / 176343	WormBaseID:	WBGene00014218	Length:	724	Species:	Caenorhabditis elegans

Alignment Length:	776	Identity:	287/776 - (36%)
Similarity:	419/776 - (53%)	Gaps:	117/776 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 GAPPGRGIGYTP-----------PGAIVPQFP-----PPGFGAPPPPELAAAFGVMATSTEWTEH 59
            |.||...|...|           |....|..|     |||.|      :..:....:..::|:.|
Worm    29 GMPPVGSIAQVPLLQMPTHSVVAPHVAAPTRPSPMLVPPGMG------IDESHSSPSVESDWSVH 87

  Fly    60 KAPDGRPYYYNQNTKQSSWEKPEALMTPAELLHNQCP----WKEYRSDTGKVYYHNVATKETCWE 120
            ....|.|||:|:.|||:||.||:.|.||.|...:..|    |||:.||.||.||:|..||:|.|.
Worm    88 TNEKGTPYYHNRVTKQTSWIKPDVLKTPLERSTSGQPQQGQWKEFMSDDGKPYYYNTLTKKTQWV 152

  Fly   121 PPPEYVDMKAKAKAEEAAAAAKAVAAMTSSSLAGMVPPAALASILPAALPVAPRLPTPEIHSPLT 185
            .|    |.:...|.|:..||.           |..|...|||:.:
Worm   153 KP----DGEEITKGEQKPAAK-----------AATVDTVALAAAV-------------------- 182

  Fly   186 PSSNENSSSAMDQAMAATLAAI-EVPQQNAKKDDKSESAVVFKDKREAIESFKELLRDR----NV 245
              ..:.:.|.:|:||.||||:: .||..:.||:::|.:..|...||:: |.|:|||||:    .:
Worm   183 --QQKKAESDLDKAMKATLASMPNVPLPSEKKEEESVNDEVELKKRQS-ERFRELLRDKYNDGKI 244

  Fly   246 PSNANWDQCVKIISKDPRYAAFKNLNERKQTFNAYKTQKIKDEREESRLKAKKAKEDLEQFLMSS 310
            .:|.||||.||.|..|||:.....::|:||.|||:|.|:.|:||:|.||..||:|||||:||...
Worm   245 TTNCNWDQAVKWIQNDPRFRILNKVSEKKQLFNAWKVQRGKEERDEKRLAIKKSKEDLEKFLQEH 309

  Fly   311 DKMNSQMKYFRCEEVFAGTRTWTAVPEPDRRDIYEDCIFNLAKREKEEARLLKKRNMKVLGELLE 375
            .||...:||.:..::|:....|.||.:.||::|:.|||..:|:|:||:....:||::.....:|:
Worm   310 PKMKESLKYQKASDIFSKEPLWIAVNDEDRKEIFRDCIDFVARRDKEKKEEDRKRDIAAFSHVLQ 374

  Fly   376 SMTSINHATTWSEAQVMLLDNVAFKNDVTLLGMDKEDALIVFEEHIRTLEKEEDEEREREKKRMK 440
            ||..|.:.|||::||.:|.:|..|.....|..|||||||.|||:||:..|||.|||:|:|:||::
Worm   375 SMEQITYKTTWAQAQRILYENPQFAERKDLHFMDKEDALTVFEDHIKQAEKEHDEEKEQEEKRLR 439

  Fly   441 RQQRKNRDSFLALLDSLHEEGKLTSMSLWVELYPIISADLRFSAMLGQSGSTPLDLFKFYVENLK 505
            |||||.|:.:..||:|||:.|:|||||||..|:||||.|.||..||.|.||:|||||||:||:||
Worm   440 RQQRKVREEYRLLLESLHKRGELTSMSLWTSLFPIISTDTRFELMLFQPGSSPLDLFKFFVEDLK 504

  Fly   506 ARFHDEKKIIREILKEKAFVVQAKTSFEDFATVVCEDKRSASLDAGNVKLTYNSLLEKAEAIEKE 570
            .::.:::::|:|||.||...|.|.|.:.:|:..|...::...:|.||:||.||||:||||:..|:
Worm   505 EQYTEDRRLIKEILTEKGCQVIATTEYREFSDWVVSHEKGGKVDHGNMKLCYNSLIEKAESKAKD 569

  Fly   571 RMKEEVRRLRKLENEIKNEWLEANVSVAEPYESAKKLVEHLEAFALYEKEIGVEKIWEDFVKESE 635
            ..||.:||.|:||:|.:|...|.||.....:...|..:|..:|:...|.:           .|.|
Worm   570 EEKESLRRKRRLESEFRNLLKEHNVDKDSEWTVIKPKIEKDKAYLAMEND-----------DERE 623

  Fly   636 DACSHHHSRS-----------RKSKKNKKHKKRVRSVSRSDIENEHIEVEKSKRRRSKTRSHSLT 689
            .|.:|:.:.:           :|.||..|.||..||.:.|:.|.|..|.||.|:::     ||..
Worm   624 TAFNHYKNGTSGTTAGSEILEKKKKKKDKKKKNKRSDNNSESEGEIREKEKKKKKK-----HSKE 683

  Fly   690 SIGSIESEKLLKKKKKRKNKLRGSSCESDVPGIQSPGTQALLQNDSNSHSPAKKKKKEKRA 750
            .  .::.|:..||.||.:.:              ||.     :::|..||..|:|::|..|
Worm   684 D--RMDDEERGKKSKKSRKR--------------SPS-----RSESPRHSSEKRKRRESEA 723

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3542	NP_608738.1	PRP40	54..634	CDD:227435	240/588 (41%)
		WW	54..81	CDD:278809	12/26 (46%)
		WW	95..122	CDD:278809	15/30 (50%)
		FF	231..280	CDD:280090	23/52 (44%)
		FF	445..500	CDD:280090	34/54 (63%)
prp-40	NP_001255005.1	WW	82..109	CDD:278809	12/26 (46%)
		WW	129..156	CDD:197736	15/30 (50%)
		FF	225..282	CDD:128718	27/57 (47%)
		FF	363..422	CDD:128718	27/58 (47%)
		FF	444..499	CDD:280090	34/54 (63%)
		FF	580..629	CDD:280090	14/59 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158559
Domainoid	1	1.000	80	1.000	Domainoid score	I5579
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	463	1.000	Inparanoid score	I864
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55014
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001909
OrthoInspector	1	1.000	-	-		oto18765
orthoMCL	1	0.900	-	-		OOG6_101966
Panther	1	1.100	-	-	LDO	PTHR11864
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2925
SonicParanoid	1	1.000	-	-		X1440
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.930