Protein Alignment Prp40 and prp-40

DIOPT Version :10

• Sequence 1: NP_608738.1
• Gene: Prp40 / 33513
• FlyBaseID: FBgn0031492
• Length: 806
• Species: Drosophila melanogaster
• Sequence 2: NP_001255005.1
• Gene: prp-40 / 176343
• WormBaseID: WBGene00014218
• Length: 724
• Species: Caenorhabditis elegans
• Alignment Length: 776
• Identity: 287/776 - (36%)
• Similarity: 419/776 - (53%)
• Gaps: 117/776 - (15%)

  Fly    11 GAPPGRGIGYTP-----------PGAIVPQFP-----PPGFGAPPPPELAAAFGVMATSTEWTEH 59
            |.||...|...|           |....|..|     |||.|      :..:....:..::|:.|
 Worm    29 GMPPVGSIAQVPLLQMPTHSVVAPHVAAPTRPSPMLVPPGMG------IDESHSSPSVESDWSVH 87

  Fly    60 KAPDGRPYYYNQNTKQSSWEKPEALMTPAELLHNQCP----WKEYRSDTGKVYYHNVATKETCWE 120
            ....|.|||:|:.|||:||.||:.|.||.|...:..|    |||:.||.||.||:|..||:|.|.
 Worm    88 TNEKGTPYYHNRVTKQTSWIKPDVLKTPLERSTSGQPQQGQWKEFMSDDGKPYYYNTLTKKTQWV 152

  Fly   121 PPPEYVDMKAKAKAEEAAAAAKAVAAMTSSSLAGMVPPAALASILPAALPVAPRLPTPEIHSPLT 185
            .|    |.:...|.|:..||.           |..|...|||:.:
 Worm   153 KP----DGEEITKGEQKPAAK-----------AATVDTVALAAAV-------------------- 182

  Fly   186 PSSNENSSSAMDQAMAATLAAI-EVPQQNAKKDDKSESAVVFKDKREAIESFKELLRDR----NV 245
              ..:.:.|.:|:||.||||:: .||..:.||:::|.:..|...||:: |.|:|||||:    .:
 Worm   183 --QQKKAESDLDKAMKATLASMPNVPLPSEKKEEESVNDEVELKKRQS-ERFRELLRDKYNDGKI 244

  Fly   246 PSNANWDQCVKIISKDPRYAAFKNLNERKQTFNAYKTQKIKDEREESRLKAKKAKEDLEQFLMSS 310
            .:|.||||.||.|..|||:.....::|:||.|||:|.|:.|:||:|.||..||:|||||:||...
 Worm   245 TTNCNWDQAVKWIQNDPRFRILNKVSEKKQLFNAWKVQRGKEERDEKRLAIKKSKEDLEKFLQEH 309

  Fly   311 DKMNSQMKYFRCEEVFAGTRTWTAVPEPDRRDIYEDCIFNLAKREKEEARLLKKRNMKVLGELLE 375
            .||...:||.:..::|:....|.||.:.||::|:.|||..:|:|:||:....:||::.....:|:
 Worm   310 PKMKESLKYQKASDIFSKEPLWIAVNDEDRKEIFRDCIDFVARRDKEKKEEDRKRDIAAFSHVLQ 374

  Fly   376 SMTSINHATTWSEAQVMLLDNVAFKNDVTLLGMDKEDALIVFEEHIRTLEKEEDEEREREKKRMK 440
            ||..|.:.|||::||.:|.:|..|.....|..|||||||.|||:||:..|||.|||:|:|:||::
 Worm   375 SMEQITYKTTWAQAQRILYENPQFAERKDLHFMDKEDALTVFEDHIKQAEKEHDEEKEQEEKRLR 439

  Fly   441 RQQRKNRDSFLALLDSLHEEGKLTSMSLWVELYPIISADLRFSAMLGQSGSTPLDLFKFYVENLK 505
            |||||.|:.:..||:|||:.|:|||||||..|:||||.|.||..||.|.||:|||||||:||:||
 Worm   440 RQQRKVREEYRLLLESLHKRGELTSMSLWTSLFPIISTDTRFELMLFQPGSSPLDLFKFFVEDLK 504

  Fly   506 ARFHDEKKIIREILKEKAFVVQAKTSFEDFATVVCEDKRSASLDAGNVKLTYNSLLEKAEAIEKE 570
            .::.:::::|:|||.||...|.|.|.:.:|:..|...::...:|.||:||.||||:||||:..|:
 Worm   505 EQYTEDRRLIKEILTEKGCQVIATTEYREFSDWVVSHEKGGKVDHGNMKLCYNSLIEKAESKAKD 569

  Fly   571 RMKEEVRRLRKLENEIKNEWLEANVSVAEPYESAKKLVEHLEAFALYEKEIGVEKIWEDFVKESE 635
            ..||.:||.|:||:|.:|...|.||.....:...|..:|..:|:...|.:           .|.|
 Worm   570 EEKESLRRKRRLESEFRNLLKEHNVDKDSEWTVIKPKIEKDKAYLAMEND-----------DERE 623

  Fly   636 DACSHHHSRS-----------RKSKKNKKHKKRVRSVSRSDIENEHIEVEKSKRRRSKTRSHSLT 689
            .|.:|:.:.:           :|.||..|.||..||.:.|:.|.|..|.||.|:::     ||..
 Worm   624 TAFNHYKNGTSGTTAGSEILEKKKKKKDKKKKNKRSDNNSESEGEIREKEKKKKKK-----HSKE 683

  Fly   690 SIGSIESEKLLKKKKKRKNKLRGSSCESDVPGIQSPGTQALLQNDSNSHSPAKKKKKEKRA 750
            .  .::.|:..||.||.:.:              ||.     :::|..||..|:|::|..|
 Worm   684 D--RMDDEERGKKSKKSRKR--------------SPS-----RSESPRHSSEKRKRRESEA 723

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prp40	NP_608738.1	PRP40	54..634	CDD:227435	240/588 (41%)
prp-40	NP_001255005.1	PRP40	76..>514	CDD:227435	199/475 (42%)
		FF	580..629	CDD:426471	14/59 (24%)