DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3542 and tcer-1

DIOPT Version :9

Sequence 1:	NP_608738.1	Gene:	CG3542 / 33513	FlyBaseID:	FBgn0031492	Length:	806	Species:	Drosophila melanogaster
Sequence 2:	NP_001370832.1	Gene:	tcer-1 / 174150	WormBaseID:	WBGene00022855	Length:	914	Species:	Caenorhabditis elegans

Alignment Length:	917	Identity:	195/917 - (21%)
Similarity:	337/917 - (36%)	Gaps:	303/917 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 VPPSV-GNGG---APP---GRGIGYTPPGAIVPQFPPPGFGAPP------PPELA---------- 44
            |||:. |.||   |||   |||.|:..|| :...|.|.|.|.||      ||...
Worm    62 VPPAARGRGGPGMAPPGFAGRGRGFATPG-MSSGFAPRGRGMPPGRGGYMPPYRGGYGVAPNGGP 125

  Fly    45 -----------AAFGVMATSTE--------------------WTEHKAPDGRPYYYNQNTKQSSW 78
                       .|:|..|....                    |.|.:..:|:.|:|:...:.:.|
Worm   126 GAYGGPYNGGPGAYGAQAPGPNPQDQEQRLKRLSGCEEGQELWVETETAEGKKYFYHPVNRNTIW 190

  Fly    79 EKPE--ALMTPAELL------------------HNQCP------WKEYRSDTGKVYYHNVATKET 117
            |:|:  .::|..||.                  |.|.|      |.|:.:..|:.||.|..|:|.
Worm   191 ERPQNAKIVTQPELAQLIHRATEEEKNREERMPHGQIPQNPDDAWNEFNAPDGRKYYFNSITQEN 255

  Fly   118 CWEPPPEYVDM-----------------KAKAKAEEAAAAAKAVAAMTSSSLAGMVPPAALASIL 165
            .||.|...:|.                 :|:|||:.|.||..|....:|:...||....|.||..
Worm   256 TWEKPKALIDQENGGGASPEPVQSAAIAEAQAKAQAALAAFMAQQKTSSNGGGGMPLSKAQASGA 320

  Fly   166 PAALPV-----------APRLPTPE---------------------------------------- 179
            .||..|           .|...||.
Worm   321 AAAAAVNAEAAKKKDSTRPISSTPVSGTPWCVVWTGDDKVFFYNPSTKCSVWERPPDTYGREDVD 385

  Fly   180 --IHSPLTPSSNENSSSAMDQAMAATLAAIEVPQQNAKKD--DKSESAVVFKDKRE--------- 231
              :.:|.:|.:.|.::.:..::.:.:.:..:.|.: |||.  :|.:.|::...|:|
Worm   386 KLVQNPPSPKAEEENNQSKKESESESESDEDGPPK-AKKSRAEKKKEALIAAQKKEKERPRQMLQ 449

  Fly   232 -----AIES-------------------FKELLRDRNVPSNANWDQCVKIISKDPRYAAFKNLNE 272
                 |||:                   |||:|.::||.:::.:::.:..|..|.||.:. ...|
Worm   450 KPVDPAIEAEMQAAKEREKVPLEERLKQFKEMLEEKNVSTSSTFEKELSKIVFDKRYLSL-GATE 513

  Fly   273 RKQTFNAYKTQKIKDEREESRLKAKKAKEDLEQFLMSSDKMNSQMKYFRCEEVFAGTRTWTAVP- 336
            |:..|:|:..:||:.|:.|.|.:.|:|||:.:: |::..::|.:..|......|.....:.||.
Worm   514 RRACFDAFCREKIESEKAERRKRVKEAKEEFQK-LLAECELNGRSSYSSFTSKFGKDPRYKAVER 577

  Fly   337 EPDRRDIYEDCIFNLAKREKEEARLLKKRNMKVLGELLESMTSINHATTWSEAQVMLLDN---VA 398
            ..||.|.:.|.:..|.|:||:|.|..|::......:|||..|.:...:.||..:..|.|.   :|
Worm   578 NRDREDAFNDFVGELHKKEKDEKRAKKEKLKAAFVKLLEEQTGLTRKSKWSTTKKTLEDEERYIA 642

  Fly   399 FKNDVTLLGMDKEDALIVFEEHIRTLEKEEDEE------------------------REREKKRM 439
            ..:..|...:.:|....:.:|....:|:|::.|                        |||.|:..
Worm   643 LDSSSTRESLFREFVANLGDETASDIEEEQEREKRLAAQTAIANRQKEVEAELGNQLRERTKESE 707

  Fly   440 KRQQRKNRDSFLALLDSLHEEGKLTSMSLWVELYPIISADLRFS--AMLGQSGSTPLDLFKFYVE 502
            |::..::.|::..||..|.   |.|..| |.|...|:..|.|::  .||.::...  .||..:::
Worm   708 KQKMGEHEDTYRNLLIDLI---KSTENS-WHEARRILRKDERYANCDMLDKTRKE--SLFDDHIK 766

  Fly   503 NLK--------------------ARFHDEKKIIREILKEKAFVVQAKTSFEDFATVVCEDKRSAS 547
            :|:                    .|:.|.||||::  :|:.|
Worm   767 SLERKRREAFFQVLDNHEKITPMMRWRDAKKIIQD--EEETF----------------------- 806

  Fly   548 LDAGNVKLTYNSLLEKAEAIEKERMKEEVRRLRKLENEIKNEWLEANVSVAEPYESAKKLVE--- 609
                 ||:..||    ...:|::....:.||...|.:|.|....|..:..    ..:|||:|
Worm   807 -----VKIASNS----ERKVERDFRDWQERRHDHLTDEFKEMLSETKIIT----HKSKKLMEEGE 858

  Fly   610 -HLEAFALYEKEIGVEKIWEDFVKESEDACSHHHSRSRKSKKNKKHKKRVRSVSRSDIENEHIEV 673
             |::..::.|.    :|.|......|            .|::::..:..:.::.|........:.
Worm   859 QHMDILSVLEN----DKRWVRMTAMS------------ASERDRMLEDHIENLGRKGTPPPPTQQ 907

  Fly   674 EKSKRRR 680
            |:.:|::
Worm   908 ERDRRKQ 914

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3542	NP_608738.1	PRP40	54..634	CDD:227435	164/784 (21%)
		WW	54..81	CDD:278809	7/46 (15%)
		WW	95..122	CDD:278809	11/32 (34%)
		FF	231..280	CDD:280090	17/81 (21%)
		FF	445..500	CDD:280090	16/56 (29%)
tcer-1	NP_001370832.1	WW	168..195	CDD:197736	8/26 (31%)
		PRP40	235..>820	CDD:227435	136/627 (22%)
		FF	834..891	CDD:396424	13/76 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910