Protein Alignment Prp40 and tcer-1

DIOPT Version :10

• Sequence 1: NP_608738.1
• Gene: Prp40 / 33513
• FlyBaseID: FBgn0031492
• Length: 806
• Species: Drosophila melanogaster
• Sequence 2: NP_001370832.1
• Gene: tcer-1 / 174150
• WormBaseID: WBGene00022855
• Length: 914
• Species: Caenorhabditis elegans
• Alignment Length: 917
• Identity: 195/917 - (21%)
• Similarity: 337/917 - (36%)
• Gaps: 303/917 - (33%)

  Fly     3 VPPSV-GNGG---APP---GRGIGYTPPGAIVPQFPPPGFGAPP------PPELA---------- 44
            |||:. |.||   |||   |||.|:..|| :...|.|.|.|.||      ||...
 Worm    62 VPPAARGRGGPGMAPPGFAGRGRGFATPG-MSSGFAPRGRGMPPGRGGYMPPYRGGYGVAPNGGP 125

  Fly    45 -----------AAFGVMATSTE--------------------WTEHKAPDGRPYYYNQNTKQSSW 78
                       .|:|..|....                    |.|.:..:|:.|:|:...:.:.|
 Worm   126 GAYGGPYNGGPGAYGAQAPGPNPQDQEQRLKRLSGCEEGQELWVETETAEGKKYFYHPVNRNTIW 190

  Fly    79 EKPE--ALMTPAELL------------------HNQCP------WKEYRSDTGKVYYHNVATKET 117
            |:|:  .::|..||.                  |.|.|      |.|:.:..|:.||.|..|:|.
 Worm   191 ERPQNAKIVTQPELAQLIHRATEEEKNREERMPHGQIPQNPDDAWNEFNAPDGRKYYFNSITQEN 255

  Fly   118 CWEPPPEYVDM-----------------KAKAKAEEAAAAAKAVAAMTSSSLAGMVPPAALASIL 165
            .||.|...:|.                 :|:|||:.|.||..|....:|:...||....|.||..
 Worm   256 TWEKPKALIDQENGGGASPEPVQSAAIAEAQAKAQAALAAFMAQQKTSSNGGGGMPLSKAQASGA 320

  Fly   166 PAALPV-----------APRLPTPE---------------------------------------- 179
            .||..|           .|...||.
 Worm   321 AAAAAVNAEAAKKKDSTRPISSTPVSGTPWCVVWTGDDKVFFYNPSTKCSVWERPPDTYGREDVD 385

  Fly   180 --IHSPLTPSSNENSSSAMDQAMAATLAAIEVPQQNAKKD--DKSESAVVFKDKRE--------- 231
              :.:|.:|.:.|.::.:..::.:.:.:..:.|.: |||.  :|.:.|::...|:|
 Worm   386 KLVQNPPSPKAEEENNQSKKESESESESDEDGPPK-AKKSRAEKKKEALIAAQKKEKERPRQMLQ 449

  Fly   232 -----AIES-------------------FKELLRDRNVPSNANWDQCVKIISKDPRYAAFKNLNE 272
                 |||:                   |||:|.::||.:::.:::.:..|..|.||.:. ...|
 Worm   450 KPVDPAIEAEMQAAKEREKVPLEERLKQFKEMLEEKNVSTSSTFEKELSKIVFDKRYLSL-GATE 513

  Fly   273 RKQTFNAYKTQKIKDEREESRLKAKKAKEDLEQFLMSSDKMNSQMKYFRCEEVFAGTRTWTAVP- 336
            |:..|:|:..:||:.|:.|.|.:.|:|||:.:: |::..::|.:..|......|.....:.||.
 Worm   514 RRACFDAFCREKIESEKAERRKRVKEAKEEFQK-LLAECELNGRSSYSSFTSKFGKDPRYKAVER 577

  Fly   337 EPDRRDIYEDCIFNLAKREKEEARLLKKRNMKVLGELLESMTSINHATTWSEAQVMLLDN---VA 398
            ..||.|.:.|.:..|.|:||:|.|..|::......:|||..|.:...:.||..:..|.|.   :|
 Worm   578 NRDREDAFNDFVGELHKKEKDEKRAKKEKLKAAFVKLLEEQTGLTRKSKWSTTKKTLEDEERYIA 642

  Fly   399 FKNDVTLLGMDKEDALIVFEEHIRTLEKEEDEE------------------------REREKKRM 439
            ..:..|...:.:|....:.:|....:|:|::.|                        |||.|:..
 Worm   643 LDSSSTRESLFREFVANLGDETASDIEEEQEREKRLAAQTAIANRQKEVEAELGNQLRERTKESE 707

  Fly   440 KRQQRKNRDSFLALLDSLHEEGKLTSMSLWVELYPIISADLRFS--AMLGQSGSTPLDLFKFYVE 502
            |::..::.|::..||..|.   |.|..| |.|...|:..|.|::  .||.::...  .||..:::
 Worm   708 KQKMGEHEDTYRNLLIDLI---KSTENS-WHEARRILRKDERYANCDMLDKTRKE--SLFDDHIK 766

  Fly   503 NLK--------------------ARFHDEKKIIREILKEKAFVVQAKTSFEDFATVVCEDKRSAS 547
            :|:                    .|:.|.||||::  :|:.|
 Worm   767 SLERKRREAFFQVLDNHEKITPMMRWRDAKKIIQD--EEETF----------------------- 806

  Fly   548 LDAGNVKLTYNSLLEKAEAIEKERMKEEVRRLRKLENEIKNEWLEANVSVAEPYESAKKLVE--- 609
                 ||:..||    ...:|::....:.||...|.:|.|....|..:..    ..:|||:|
 Worm   807 -----VKIASNS----ERKVERDFRDWQERRHDHLTDEFKEMLSETKIIT----HKSKKLMEEGE 858

  Fly   610 -HLEAFALYEKEIGVEKIWEDFVKESEDACSHHHSRSRKSKKNKKHKKRVRSVSRSDIENEHIEV 673
             |::..::.|.    :|.|......|            .|::::..:..:.::.|........:.
 Worm   859 QHMDILSVLEN----DKRWVRMTAMS------------ASERDRMLEDHIENLGRKGTPPPPTQQ 907

  Fly   674 EKSKRRR 680
            |:.:|::
 Worm   908 ERDRRKQ 914

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prp40	NP_608738.1	PRP40	54..634	CDD:227435	164/784 (21%)
tcer-1	NP_001370832.1	WW	168..195	CDD:197736	8/26 (31%)
		PRP40	235..>820	CDD:227435	136/627 (22%)
		FF	834..891	CDD:426471	13/76 (17%)