Protein Alignment Prp40 and prpf40a

DIOPT Version :10

• Sequence 1: NP_608738.1
• Gene: Prp40 / 33513
• FlyBaseID: FBgn0031492
• Length: 806
• Species: Drosophila melanogaster
• Sequence 2: NP_001243869.1
• Gene: prpf40a / 100170464
• XenbaseID: XB-GENE-988694
• Length: 922
• Species: Xenopus tropicalis
• Alignment Length: 897
• Identity: 380/897 - (42%)
• Similarity: 520/897 - (57%)
• Gaps: 123/897 - (13%)

  Fly     3 VPPSVGNGGAPP-GRGIGYTPPGAIVP------------QFPPPGFGA----------PPP---- 40
            :||.:|..|.|. |:...:..|..|.|            |..||...|          |||
 Frog    54 IPPLLGPMGGPQMGQACLFQMPSMIPPLMSGMMMATHVAQGLPPSMQAGINSMEPPLVPPPVAQA 118

  Fly    41 --PELAAAFGVMATST----------EWTEHKAPDGRPYYYNQNTKQSSWEKPEALMTPAELLHN 93
              |.:||...|.:.||          :|||||:||||.||||..||||:||||:.:.||||.|.:
 Frog   119 VHPIVAAQQAVSSNSTGSEEQTKLKLQWTEHKSPDGRTYYYNAETKQSTWEKPDDMKTPAEQLLS 183

  Fly    94 QCPWKEYRSDTGKVYYHNVATKETCWEPPPEYVDMKAKAKAEEAAAAAK-----AVAAMTSSSLA 153
            :|||||::||:||.||:|..|||:.|..|.|..:::...||||.::|::     ||.|..:..:.
 Frog   184 KCPWKEFKSDSGKPYYYNSQTKESRWAKPKELEEVEVMIKAEENSSASEEPMPVAVPAAPTIEVN 248

  Fly   154 GMVPPAALASILPAALPVAPRL-------PTPEIHSPLTPSSNENSSSAMDQAMAATLAAIEVPQ 211
            .|..|.|:.|.:..:.|..|.:       .|.|..:|:..|..|....|:..|:.......|.|.
 Frog   249 SMPTPQAIESEIAHSDPTTPAIDTETAVAETEEQPAPIASSLQEKEVEAIGNAVTEQPPKAETPV 313

  Fly   212 QNAKKDDKSE-----SAVVFKDKREAIESFKELLRDRNVPSNANWDQCVKIISKDPRYAAFKNLN 271
            ::...::|.|     ....:..|.||.::|||||:::.|||||.|:|.:|:|..||||:|...|:
 Frog   314 ESTPVEEKEEEKAPKKVYTWNTKEEAKQAFKELLKEKRVPSNATWEQAMKMIINDPRYSALAKLS 378

  Fly   272 ERKQTFNAYKTQKIKDEREESRLKAKKAKEDLEQFLMSSDKMNSQMKYFRCEEVFAGTRTWTAVP 336
            |:||.:||||.|..|:|:||:|||.|:|||..::||.:.:||.|..:|.:.|::|.....|.|:.
 Frog   379 EKKQAYNAYKVQTEKEEKEEARLKYKEAKESFQKFLENHEKMTSTTRYKKAEQMFGDHEVWNAIT 443

  Fly   337 EPDRRDIYEDCIFNLAKREKEEARLLKKRNMKVLGELLESMTSINHATTWSEAQVMLLDNVAFKN 401
            |.||.:||||.:|.|||:|||:|:.|:|||.:.|..:|::||::.::|||||||..|:||..|..
 Frog   444 ERDRLEIYEDVLFFLAKKEKEQAKQLRKRNWEALKNILDNMTNVTYSTTWSEAQQYLMDNPTFAE 508

  Fly   402 DVTLLGMDKEDALIVFEEHIRTLEKEEDEEREREKKRMKRQQRKNRDSFLALLDSLHEEGKLTSM 466
            |..|..||||||||.||||||||||||::|:::...|.:|:|||||:||...||.||:.|:|.||
 Frog   509 DEELQNMDKEDALICFEEHIRTLEKEEEDEKQKALLRERRRQRKNRESFQIFLDELHDHGQLHSM 573

  Fly   467 SLWVELYPIISADLRFSAMLGQ-----------SGSTPLDLFKFYVENLKARFHDEKKIIREILK 520
            |.|:||||.:|:|:||:.||||           .|||.|||||||||.||||:|||||||::||:
 Frog   574 SSWMELYPTVSSDIRFANMLGQPGPGPKTALHTQGSTALDLFKFYVEGLKARYHDEKKIIKDILR 638

  Fly   521 EKAFVVQAKTSFEDFATVVCEDKRSASLDAGNVKLTYNSLLEKAEAIEKERMKEEVRRLRKLENE 585
            :|:|||:..|:|:||.||:...||:.:|||||:||.:|||||||||.|:||.|||.|::::.|:.
 Frog   639 DKSFVVELSTTFDDFVTVISSTKRATTLDAGNIKLAFNSLLEKAEAREREREKEEARKMKRKESA 703

  Fly   586 IKNEWLEANVSVAEPYESAKKLVEHLEAFALYEKEIGVE---------KIWEDFVKESEDACSHH 641
            .|:...:|    |.|.|......|..|.|.   ||...|         :|::|||...|..|.||
 Frog   704 FKSMLKQA----APPIEGDSVWEEVRERFT---KEPAFEDITLESERKRIFKDFVLAIEHECQHH 761

  Fly   642 HSRSRK-SKKNKK-HKKRVRSVSRSDIENEHIEVEKSKRRRSKTRSHSLTSIGSIESEKLLKKKK 704
            ||::|| |||:|| |:||.||.|.|:.|.|.....|.||::|.:||.|..| .|.||||..||.|
 Frog   762 HSKNRKHSKKSKKHHRKRSRSRSGSESEEEDENHTKKKRQKSDSRSGSEHS-SSGESEKSYKKTK 825

  Fly   705 KRKNKLRGSSCESDVPGIQSPGTQALLQND---------------SNSHSPAKKKKKEKRAKKDK 754
            |.|.|.:....:|:     ||.|....:.|               ..|.....|::.|.:.|..|
 Frog   826 KHKKKSKKRRHKSN-----SPETDGEKERDREREKKERDRDREKEKESEKDRSKRRSESKLKSPK 885

  Fly   755 RHNRHNRSGTPLSPAQSVESSGSRNEELTLSDGELESKRAALLAQLSEQLDE 806
            |..|.| |||       .::|||.     ||:||||.:|..||    ||||:
 Frog   886 RKGRKN-SGT-------WDTSGSE-----LSEGELEKRRRTLL----EQLDD 920

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prp40	NP_608738.1	PRP40	54..634	CDD:227435	286/626 (46%)
prpf40a	NP_001243869.1	PRP40	146..>638	CDD:227435	233/491 (47%)
		FF	698..751	CDD:128718	14/59 (24%)
		SF-CC1	840..>922	CDD:273721	31/98 (32%)